DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8915 and dhx32a

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001189401.3	Gene:	dhx32a / 100006246	ZFINID:	ZDB-GENE-130613-6	Length:	728	Species:	Danio rerio

Alignment Length:	756	Identity:	195/756 - (25%)
Similarity:	320/756 - (42%)	Gaps:	129/756 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 MAGNVERRLMNSVGDLKCNKQQY----KDIRLPSNFGLVGQRLIPPPQSNRNRNIQHERRSLPIY 212
            ||||.|  |...:|..:.:.:..    .|:.|....||        |.|:|...:..||::||::
Zfish     1 MAGNGE--LSGELGKEEEDSENLFEFGDDLELNQFDGL--------PYSSRYYRLLQERKTLPVW 55

  Fly   213 KQRESILNVLQRDQVLIIKGATGSGKSTQLPQYILEW--AAEHRAPVRIVVSQPRRIAAISVSER 275
            |.|...:.:|:.:|:||:.|.|.:|||||:||:..|:  :|:::..| :|.||.:|..|:.::.|
Zfish    56 KYRHEFMTLLENNQILIVSGTTKTGKSTQIPQWCAEFCLSAQYQHGV-VVCSQIQRRQAVDLALR 119

  Fly   276 ISKERGEAPGTTVGYNIRMNRQCSSNTVLMLTTSGCLLRALAMDKKSFFKNTTHLIIDEAHERDL 340
            ::.|.....|..:||:|.:...||::|:|...|...|||.:..|  ...:....:::|:||||.:
Zfish   120 VADEMDVNIGHEIGYSIPLETCCSNDTILRYCTDDILLREMMSD--PLLEQYGVVLVDQAHERTV 182

  Fly   341 DTDFLLLATKLELQKNPHLRLVLMSATMDLEALSNYFGGGTVMDVEGRSFEVSIYHLEDILSKTG 405
            .||.||...:..|.:.|.||||::||....|.|..::|            .|...||
Zfish   183 STDVLLGLLREVLLQRPELRLVVLSAPPTPETLLTHYG------------SVPRLHL-------- 227

  Fly   406 YMHPRMEKFLGKPTGKETPSELLAAYYGGNTIVHPDIDNDLIVSLLELLL---RQGDAGAVIVYL 467
                            |.||       .|..|......::...|.|.|.|   |..:.|.|.|:|
Zfish   228 ----------------EAPS-------AGEVIHSSSSSSESFYSALRLALEVHRSREPGDVAVFL 269

  Fly   468 PGYSD-------MTSLLARLESSLPREQITIILLHSQ------VDNSEQ--RKVFRTYPGVRLKI 517
            ....:       :|...:|:..|| .|.:.:.:....      |..|.|  |::|
Zfish   270 ATEQEVVCACNIITKEASRMSVSL-GELLAVPMCSGHAGICPPVTESPQMSRRIF---------- 323

  Fly   518 ILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLTLTWISQADAKQRAGRAGRVCHGNCY 582
            :..:.:.....::..:.:|||||:.|...|:..:.||...:..||:..|:.|....|..  |.|:
Zfish   324 VSCSQLEDLFWSVDSIAFVIDTGVEKRLVYNPRLRASSEVIRPISKCQAEMRKQLTGST--GKCF 386

  Fly   583 RLYDNDRMARMNLYTIPEIMRRTLDEICL-LTKLAAPDKKIENFLALALDTPPKDAVMQSCSRLK 646
            .||..|......::  |.|:...:....| |.::.|......:|    ::.|..:.:||:...|.
Zfish   387 CLYPEDVQLPAEIH--PRILESNITSTALFLKRMEAAGVTHCHF----INRPDPEGLMQALEELD 445

  Fly   647 LLGVLDERDEVTPLGHIVAELPLGVQIGKCLVYSIYLRCLDSMIIIAAYHSVRDPFV-------L 704
            .|..||....::.:|.|::||||..|:.|.|:.|....|...|:.|||..:....|:       .
Zfish   446 YLAALDNDGNLSEMGIIMSELPLEPQMAKALLASCEFDCASEMLTIAAMLTAPSCFIEPPVGMLT 510

  Fly   705 NIERGKKSGQQISRVLFAGDGMSDSLAVIKLYEEFTNLKRKDI---GDFCERNFICRNAMEMFVS 766
            .:.|.....|...         .|...:|.:|..|...:|:..   ..:||:.::|..|::...:
Zfish   511 EVMRCHMKFQHPE---------GDHFTLINIYNTFKRSQREPYFSQEQWCEQYYLCCAALQTADA 566

  Fly   767 AASTLRDTVYRI-FRFSEASARLASSFNNDTNM--IRLALTAGLYPKLAYMDRENKNQLVAEGDP 828
            ..|.|.|.:.|| ...||      .:|...||.  |:.||.||.:.::|.....:.|..:.....
Zfish   567 IRSQLSDVLKRIELPISE------PAFGTKTNALNIKRALLAGYFMQMARDVDGSGNYFMLLNKH 625

  Fly   829 LVQVSRSSCLRGKKKQKDLASEWILFVEKTRTADQISSLEH 869
            :.|..|.|.. |.|.||....||:||.|.:.|.:.|.:|.|
Zfish   626 VAQAHRLSAY-GAKAQKLGLPEWLLFHEYSLTDNSIRTLTH 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064
		DEXDc	214..395	CDD:214692	58/182 (32%)
		DEXDc	226..368	CDD:238005	52/143 (36%)
		HELICc	479..575	CDD:197757	22/103 (21%)
		HA2	648..733	CDD:214852	22/91 (24%)
		OB_NTP_bind	783..884	CDD:285018	27/89 (30%)
dhx32a	NP_001189401.3	HrpA	14..>610	CDD:224557	170/683 (25%)
dhx32a	NP_001189401.3	OB_NTP_bind	569..678	CDD:311586	33/104 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900