DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5162 and LIPG

DIOPT Version :9

Sequence 1:	NP_001285367.1	Gene:	CG5162 / 32709	FlyBaseID:	FBgn0030828	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	XP_005258447.1	Gene:	LIPG / 9388	HGNCID:	6623	Length:	536	Species:	Homo sapiens

Alignment Length:	396	Identity:	102/396 - (25%)
Similarity:	162/396 - (40%)	Gaps:	107/396 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 PTPQGLLEGSKQLIAGYPFEFVSNSLNVICSQALASNKIKSKYSPDINK---------------- 99
            |.|.|:..|...  :|.|.|.....|.::.|| |.:.:.:.:..|.:.:
Human    21 PPPLGMAVGRGG--SGCPEEGSGRKLELLESQ-LPAERAREEAGPSVRRPRDKLHKPKATQTEVK 82

  Fly   100 --MNFQLQTACEKKNFPLTSPESMWKS-----PL----FDVKKKVVILATGWTTTVNGSDTIEVF 153
              :.|.|:|:.:.::      |..:.|     ||    |::..|...:..|||.:....:.:...
Human    83 PSVRFNLRTSKDPEH------EGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKL 141

  Fly   154 SKAYNCR-GDVNFVAVDAARFVDTLYTWSAFNTEEIGENIALGLVKLLDLV------PVENIHLI 211
            ..|.:.| .|.|.|.||.......|||.:..||..:|.:||    ::||.:      .:.|:|||
Human   142 VSALHTREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIA----RMLDWLQEKDDFSLGNVHLI 202

  Fly   212 GHSLGAHIVGSAGRHLQHLTNQTIPRITGLDPAKPCFNEGEALSGLMRGDAHFVDVIHS---NPG 273
            |:|||||:.|.||    :....|:.||||||||.|.|...:....|...||.||||:|:   :.|
Human   203 GYSLGAHVAGYAG----NFVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFG 263

  Fly   274 V-LGKRDPVGDVDFYPGG------------MSPLAAGCFS--VTCAHARSWEYFAETVFPGNERN 323
            : :|.:.|||.:|.||.|            :..:|.|..:  |.|.|.|:...|.:::...::.:
Human   264 LSIGIQMPVGHIDIYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPS 328

  Fly   324 F------------------MATRCNSI----SKLRDFRCPGDEVPMGYAVPQNIKGNYFLEVSAS 366
            |                  ...|||||    .|:|:.|                ....:|:..|.
Human   329 FAFQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKR----------------NSKMYLKTRAG 377

  Fly   367 APFGMH 372
            .||.::
Human   378 MPFRVY 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5162	NP_001285367.1	Lipase	94..369	CDD:278576	89/348 (26%)
CG5162	NP_001285367.1	Pancreat_lipase_like	99..365	CDD:238363	87/339 (26%)
LIPG	XP_005258447.1	Pancreat_lipase_like	85..376	CDD:238363	87/320 (27%)
		lipo_lipase	86..521	CDD:132274	90/328 (27%)
		PLAT_LPL	383..519	CDD:238856	0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145247
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940