Protein Alignment CG5162 and Lpl

DIOPT Version :10

• Sequence 1: NP_573202.1
• Gene: CG5162 / 32709
• FlyBaseID: FBgn0030828
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_036730.1
• Gene: Lpl / 24539
• RGDID: 3017
• Length: 474
• Species: Rattus norvegicus
• Alignment Length: 313
• Identity: 94/313 - (30%)
• Similarity: 134/313 - (42%)
• Gaps: 65/313 - (20%)

  Fly   110 KKNFPLTSPESMWKSPL--------------FDVKKKVVILATGWTTT-VNGSDTIEVFSKAYNC 159
            :..|.|.:||...:...              |:...|..::..|||.| :..|...::.:..|..
  Rat    38 ESKFALRTPEDTAEDTCHLIPGLADSVSNCHFNHSSKTFVVIHGWTVTGMYESWVPKLVAALYKR 102

  Fly   160 RGDVNFVAVDAARFVDTLYTWSAFNTEEIGENIALGLVKLLD---LVPVENIHLIGHSLGAHIVG 221
            ..|.|.:.||........|..||..|:.:|.::| ..:..|:   ..|::|:||:|:|||||..|
  Rat   103 EPDSNVIVVDWLYRAQQHYPVSAGYTKLVGNDVA-RFINWLEEEFNYPLDNVHLLGYSLGAHAAG 166

  Fly   222 SAGRHLQHLTNQTIPRITGLDPAKPCFNEGEALSGLMRGDAHFVDVIHS----NPG-VLGKRDPV 281
            .||    .|||:.:.||||||||.|.|...||.|.|...||.||||:|:    :|| .:|.:.||
  Rat   167 VAG----SLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPV 227

  Fly   282 GDVDFYPGGMSPLAAGC------------------FSVTCAHARSWEYFAETVFPGNERN-FMAT 327
            |.||.||.| .....||                  ..|.|:|.||...|.:::.  ||.| ..|.
  Rat   228 GHVDIYPNG-GTFQPGCNIGEAIRVIAEKGLGDVDQLVKCSHERSIHLFIDSLL--NEENPSKAY 289

  Fly   328 RCNS--------ISKLRDFRCPGDEVPMGYAVPQ---NIKGNYFLEVSASAPF 369
            ||||        ....|..||..    :||.:.:   ......:|:..:..|:
  Rat   290 RCNSKEAFEKGLCLSCRKNRCNN----VGYEINKVRAKRSSKMYLKTRSQMPY 338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5162	NP_573202.1	Pancreat_lipase_like	99..365	CDD:238363	93/307 (30%)
Lpl	NP_036730.1	Interaction with GPIHBP1. /evidence=ECO:0000250|UniProtKB:P06858	32..53		4/14 (29%)
		lipo_lipase	33..472	CDD:132274	94/313 (30%)
		Essential for determining substrate specificity. /evidence=ECO:0000250|UniProtKB:P06858	243..266		2/22 (9%)
		Important for interaction with lipoprotein particles. /evidence=ECO:0000250|UniProtKB:P06858	417..421
		Important for heparin binding. /evidence=ECO:0000250|UniProtKB:P06858	430..434
		Interaction with GPIHBP1. /evidence=ECO:0000250|UniProtKB:P06858	443..467