DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5162 and Lpl

DIOPT Version :9

Sequence 1:	NP_001285367.1	Gene:	CG5162 / 32709	FlyBaseID:	FBgn0030828	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_032535.2	Gene:	Lpl / 16956	MGIID:	96820	Length:	474	Species:	Mus musculus

Alignment Length:	316	Identity:	93/316 - (29%)
Similarity:	135/316 - (42%)	Gaps:	71/316 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 KKNFPLTSPESMWKSPL--------------FDVKKKVVILATGWTTT-VNGSDTIEVFSKAYNC 159
            :..|.|.:||...:...              |:...|..::..|||.| :..|...::.:..|..
Mouse    38 ESKFALRTPEDTAEDTCHLIPGLADSVSNCHFNHSSKTFVVIHGWTVTGMYESWVPKLVAALYKR 102

  Fly   160 RGDVNFVAVDAARFVDTLYTWSAFNTEEIGENIALGLVKLLDLV------PVENIHLIGHSLGAH 218
            ..|.|.:.||........|..||..|:.:|.::|    :.::.:      |::|:||:|:|||||
Mouse   103 EPDSNVIVVDWLYRAQQHYPVSAGYTKLVGNDVA----RFINWMEEEFNYPLDNVHLLGYSLGAH 163

  Fly   219 IVGSAGRHLQHLTNQTIPRITGLDPAKPCFNEGEALSGLMRGDAHFVDVIHS----NPG-VLGKR 278
            ..|.||    .|||:.:.||||||||.|.|...||.|.|...||.||||:|:    :|| .:|.:
Mouse   164 AAGVAG----SLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQ 224

  Fly   279 DPVGDVDFYPGGMSPLAAGC------------------FSVTCAHARSWEYFAETVFPGNERN-F 324
            .|||.||.||.| .....||                  ..|.|:|.||...|.:::.  ||.| .
Mouse   225 KPVGHVDIYPNG-GTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLL--NEENPS 286

  Fly   325 MATRCNS--------ISKLRDFRCPGDEVPMGYAVPQ---NIKGNYFLEVSASAPF 369
            .|.||||        ....|..||..    :||.:.:   ......:|:..:..|:
Mouse   287 KAYRCNSKEAFEKGLCLSCRKNRCNN----LGYEINKVRAKRSSKMYLKTRSQMPY 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5162	NP_001285367.1	Lipase	94..369	CDD:278576	92/314 (29%)
CG5162	NP_001285367.1	Pancreat_lipase_like	99..365	CDD:238363	92/310 (30%)
Lpl	NP_032535.2	Interaction with GPIHBP1. /evidence=ECO:0000250\|UniProtKB:P06858	32..53		4/14 (29%)
		lipo_lipase	33..472	CDD:132274	93/316 (29%)
		Pancreat_lipase_like	37..334	CDD:238363	92/310 (30%)
		Essential for determining substrate specificity. /evidence=ECO:0000250\|UniProtKB:P06858	243..266		2/22 (9%)
		PLAT_LPL	341..465	CDD:238856
		Important for interaction with lipoprotein particles. /evidence=ECO:0000250\|UniProtKB:P06858	417..421
		Important for heparin binding. /evidence=ECO:0000250\|UniProtKB:P06858	430..434
		Interaction with GPIHBP1. /evidence=ECO:0000250\|UniProtKB:P06858	443..467
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010