DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5162 and PNLIPRP3

DIOPT Version :9

Sequence 1:	NP_001285367.1	Gene:	CG5162 / 32709	FlyBaseID:	FBgn0030828	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_001011709.2	Gene:	PNLIPRP3 / 119548	HGNCID:	23492	Length:	467	Species:	Homo sapiens

Alignment Length:	402	Identity:	106/402 - (26%)
Similarity:	157/402 - (39%)	Gaps:	135/402 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PAKMHTLLALLLQLLVASIHAIEWSLPDVINSIGNVGTSIVDPSLLPTPQGLLEGSKQLIAGYPF 69
            |.|::|      :.|:.:||.     |:....|..|.:|.:..|...|.    :.::..|||:
Human    49 PEKINT------RFLLYTIHN-----PNAYQEISAVNSSTIQASYFGTD----KITRINIAGW-- 96

  Fly    70 EFVSNSLNVICSQALASNKIKSKYSPDINKMNFQLQTACEKKNFPLTSPESMWKSPLFDVKKKVV 134
                              |...|:..|:..:..||:                      |:.
Human    97 ------------------KTDGKWQRDMCNVLLQLE----------------------DIN---- 117

  Fly   135 ILATGWTTTVNGSDTIEVFSKAYNCRGDVNFVAVDAARFVDTLYTWSAFNTEEIGENIALGLVKL 199
            .:...|   :|||   ..:..|.|   ::..|..:.|.|:|.                   |:|.
Human   118 CINLDW---INGS---REYIHAVN---NLRVVGAEVAYFIDV-------------------LMKK 154

  Fly   200 LDLVPVENIHLIGHSLGAHIVGSAGRHLQHLTNQTIPRITGLDPAKPCFNEGEALSGLMRGDAHF 264
            .:..| ..:||||||||||:.|.||..:..|     .||||||||.|.|:.......|...||:|
Human   155 FEYSP-SKVHLIGHSLGAHLAGEAGSRIPGL-----GRITGLDPAGPFFHNTPKEVRLDPSDANF 213

  Fly   265 VDVIHSNP-------GVLGKRDPVGDVDFYPGG----------MSPLAAGCFSV---------TC 303
            |||||:|.       || |..|..|.:||||.|          ::||....|:.         .|
Human   214 VDVIHTNAARILFELGV-GTIDACGHLDFYPNGGKHMPGCEDLITPLLKFNFNAYKKEMASFFDC 277

  Fly   304 AHARSWEYFAETVFPGNERNFMATRCNSISKLRD---FRCPGDEVP-MGYAVP----QNIKGN-- 358
            .||||::::||::.  |...|:|..|.|.:..:.   |.|..:..| ||:...    :|:|.|
Human   278 NHARSYQFYAESIL--NPDAFIAYPCRSYTSFKAGNCFFCSKEGCPTMGHFADRFHFKNMKTNGS 340

  Fly   359 -YFLEVSASAPF 369
             |||...:.:||
Human   341 HYFLNTGSLSPF 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5162	NP_001285367.1	Lipase	94..369	CDD:278576	87/311 (28%)
CG5162	NP_001285367.1	Pancreat_lipase_like	99..365	CDD:238363	86/302 (28%)
PNLIPRP3	NP_001011709.2	Lipase	18..352	CDD:278576	104/400 (26%)
		Pancreat_lipase_like	52..348	CDD:238363	102/393 (26%)
		PLAT_PL	355..467	CDD:238857
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145262
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28N19
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840