DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18258 and PNLIPRP2

DIOPT Version :9

Sequence 1:	NP_573201.1	Gene:	CG18258 / 32708	FlyBaseID:	FBgn0265267	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_005387.3	Gene:	PNLIPRP2 / 5408	HGNCID:	9157	Length:	469	Species:	Homo sapiens

Alignment Length:	276	Identity:	90/276 - (32%)
Similarity:	128/276 - (46%)	Gaps:	37/276 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 KLIP----DMSRMSFLLRSSDDCQNTSIPLTQAEQLWNTTGFYQDRPTVLFITGWTTSINNSNSG 224
            ||:|    |:. ..|||.::::..|..:...........:.|..||.|...|.|:.....:|...
Human    43 KLLPWSPEDID-TRFLLYTNENPNNFQLITGTEPDTIEASNFQLDRKTRFIIHGFLDKAEDSWPS 106

  Fly   225 PVAKAYLCRNDTNVLILDAANFIDTLYTWSALNTEVIGDYLAKALLRLNT--SYVTKQFHLVGHS 287
            .:.|........|.:.:|..:....:||.:..|..|:|...|..:..|:|  .|..:..|::|||
Human   107 DMCKKMFEVEKVNCICVDWRHGSRAMYTQAVQNIRVVGAETAFLIQALSTQLGYSLEDVHVIGHS 171

  Fly   288 LGAQIAGSAGRNYRRLSGGQILKRITGLDPANPCFYDGNELEGLRSGDARFVDIIHTN-----PG 347
            |||..|..||   ||| ||:: .||||||||.|||.|..|...|...||.|||:|||:     |.
Human   172 LGAHTAAEAG---RRL-GGRV-GRITGLDPAGPCFQDEPEEVRLDPSDAVFVDVIHTDSSPIVPS 231

  Fly   348 M-FGTSKRAGDADFFVQGRIPFKPGCE--------SLDPI--------SCSHQRAVDYWTETVYP 395
            : ||.|::.|..|||..|.... |||:        .:|.|        ||:|.|:.:|::.:|.
Human   232 LGFGMSQKVGHLDFFPNGGKEM-PGCKKNVLSTITDIDGIWEGIGGFVSCNHLRSFEYYSSSVL- 294

  Fly   396 SNGNDFLAKRCKRYSE 411
             |.:.||...|..|.|
Human   295 -NPDGFLGYPCASYDE 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18258	NP_573201.1	Pancreat_lipase_like	172..443	CDD:238363	86/264 (33%)
PNLIPRP2	NP_005387.3	Lipase	18..354	CDD:395099	90/276 (33%)
		Required for galactolipase activity. /evidence=ECO:0000269\|PubMed:26494624	93..105		3/11 (27%)
		Required for galactolipase activity. /evidence=ECO:0000269\|PubMed:26494624	257..279		2/21 (10%)
		PLAT_PL	357..469	CDD:238857
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145359
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940