DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18258 and PNLIP

DIOPT Version :9

Sequence 1:	NP_573201.1	Gene:	CG18258 / 32708	FlyBaseID:	FBgn0265267	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_000927.1	Gene:	PNLIP / 5406	HGNCID:	9155	Length:	465	Species:	Homo sapiens

Alignment Length:	308	Identity:	91/308 - (29%)
Similarity:	140/308 - (45%)	Gaps:	60/308 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 FLLRSSDDCQNTSIPLTQAEQLWNTTGFYQDRPTVLFITGWTTSINNSNSGPVAKAYLCRN---- 234
            |||.::::..|.......:..: :.:.|..:|.|...|.|:   |:......:|.  :|:|
Human    55 FLLYTNENPNNFQEVAADSSSI-SGSNFKTNRKTRFIIHGF---IDKGEENWLAN--VCKNLFKV 113

  Fly   235 -DTNVLILDAANFIDTLYTWSALNTEVIGDYLAKALLRLNTS--YVTKQFHLVGHSLGAQIAGSA 296
             ..|.:.:|......|.||.::.|..::|..:|..:..|.::  |.....|::||||||..||.|
Human   114 ESVNCICVDWKGGSRTGYTQASQNIRIVGAEVAYFVEFLQSAFGYSPSNVHVIGHSLGAHAAGEA 178

  Fly   297 GRNYRRLSGGQILKRITGLDPANPCFYDGNELEGLRSGDARFVDIIHTN-----PGM-FGTSKRA 355
            |   ||.:|  .:.||||||||.|||....||..|...||:|||:|||:     |.: ||.|:..
Human   179 G---RRTNG--TIGRITGLDPAEPCFQGTPELVRLDPSDAKFVDVIHTDGAPIVPNLGFGMSQVV 238

  Fly   356 GDADFFVQGRIPFKPGCE--------SLDPI--------SCSHQRAVDYWTETVYPSNG------ 398
            |..|||..|.:.. |||:        .:|.|        :|:|.|:..|:|:::...:|
Human   239 GHLDFFPNGGVEM-PGCKKNILSQIVDIDGIWEGTRDFAACNHLRSYKYYTDSIVNPDGFAGFPC 302

  Fly   399 ---NDFLAKRCKRYSE---LLLGNYCKNTNTVMGYAAKATDLG-LFYV 439
               |.|.|.:|.....   ..:|:|...      |..|..|:| .||:
Human   303 ASYNVFTANKCFPCPSGGCPQMGHYADR------YPGKTNDVGQKFYL 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18258	NP_573201.1	Pancreat_lipase_like	172..443	CDD:238363	91/308 (30%)
PNLIP	NP_000927.1	Lipase	17..352	CDD:278576	91/308 (30%)
PNLIP	NP_000927.1	PLAT_PL	355..465	CDD:238857
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145365
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28N19
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840