DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18258 and Lpl

DIOPT Version :9

Sequence 1:	NP_573201.1	Gene:	CG18258 / 32708	FlyBaseID:	FBgn0265267	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_032535.2	Gene:	Lpl / 16956	MGIID:	96820	Length:	474	Species:	Mus musculus

Alignment Length:	327	Identity:	91/327 - (27%)
Similarity:	137/327 - (41%)	Gaps:	57/327 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 DLGVVRSKLIPDMSRMSFLLRSSDDCQNTSIPLTQ--AEQLWNTTGFYQDRPTVLFITGWTTSIN 219
            |...:.||         |.||:.:|....:..|..  |:.:.| ..|.....|.:.|.|||.:..
Mouse    33 DFSDIESK---------FALRTPEDTAEDTCHLIPGLADSVSN-CHFNHSSKTFVVIHGWTVTGM 87

  Fly   220 NSNSGP--VAKAYLCRNDTNVLILDAANFIDTLYTWSALNTEVIGDYLAKAL--LRLNTSYVTKQ 280
            ..:..|  ||..|....|:||:::|........|..||..|:::|:.:|:.:  :....:|....
Mouse    88 YESWVPKLVAALYKREPDSNVIVVDWLYRAQQHYPVSAGYTKLVGNDVARFINWMEEEFNYPLDN 152

  Fly   281 FHLVGHSLGAQIAGSAGRNYRRLSGGQILKRITGLDPANPCFYDGNELEGLRSGDARFVDIIHT- 344
            .||:|:||||..||.||    .|:..:: .||||||||.|.|........|...||.|||::||
Mouse   153 VHLLGYSLGAHAAGVAG----SLTNKKV-NRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTF 212

  Fly   345 ---NPG-MFGTSKRAGDADFFVQGRIPFKPGCE--------------SLDP-ISCSHQRAVDYWT 390
               :|| ..|..|..|..|.:..|. .|:|||.              .:|. :.|||:|::..:.
Mouse   213 TRGSPGRSIGIQKPVGHVDIYPNGG-TFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFI 276

  Fly   391 ETVYPSNGNDFLAKRCKRYSELLLG-------NYCKNTNTVMGY---AAKATDLGLFYVGANPEE 445
            :::. :..|...|.||........|       |.|.|    :||   ..:|......|:....:.
Mouse   277 DSLL-NEENPSKAYRCNSKEAFEKGLCLSCRKNRCNN----LGYEINKVRAKRSSKMYLKTRSQM 336

  Fly   446 PY 447
            ||
Mouse   337 PY 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18258	NP_573201.1	Pancreat_lipase_like	172..443	CDD:238363	86/306 (28%)
Lpl	NP_032535.2	Interaction with GPIHBP1. /evidence=ECO:0000250\|UniProtKB:P06858	32..53		7/28 (25%)
		lipo_lipase	33..472	CDD:132274	91/327 (28%)
		Pancreat_lipase_like	37..334	CDD:238363	88/317 (28%)
		Essential for determining substrate specificity. /evidence=ECO:0000250\|UniProtKB:P06858	243..266		2/22 (9%)
		PLAT_LPL	341..465	CDD:238856
		Important for interaction with lipoprotein particles. /evidence=ECO:0000250\|UniProtKB:P06858	417..421
		Important for heparin binding. /evidence=ECO:0000250\|UniProtKB:P06858	430..434
		Interaction with GPIHBP1. /evidence=ECO:0000250\|UniProtKB:P06858	443..467
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010