Protein Alignment rnf145b and RNF145

DIOPT Version :10

• Sequence 1: NP_956057.1
• Gene: rnf145b / 327056
• ZFINID: ZDB-GENE-030131-5264
• Length: 685
• Species: Danio rerio
• Sequence 2: NP_001186309.1
• Gene: RNF145 / 153830
• HGNCID: 20853
• Length: 693
• Species: Homo sapiens
• Alignment Length: 628
• Identity: 528/628 - (84%)
• Similarity: 575/628 - (91%)
• Gaps: 6/628 - (0%)

Zfish     1 MAMKARLESVLNVGLRIPSIMLLEVLYRWDVSSFFQKIQRSSLNNNPVFQYKYIALYLHYVGYIL 65
            ||.|.:||:||||.||:||||||:||||||||||||:||||||:|||:|||||:||.:|||||||
Human    31 MAAKEKLEAVLNVALRVPSIMLLDVLYRWDVSSFFQQIQRSSLSNNPLFQYKYLALNMHYVGYIL 95

Zfish    66 SLVLLTLPRQHLVQLYLYVLTALLLFAGHQLSRDYVRGELDSGYEGPLYLEPLSMNRFTTALIGQ 130
            |:||||||||||||||||.||||||:||||:||||||.||:..||||:|||||||||||||||||
Human    96 SVVLLTLPRQHLVQLYLYFLTALLLYAGHQISRDYVRSELEFAYEGPMYLEPLSMNRFTTALIGQ 160

Zfish   131 VVVCTLCSCVMQTRQIWLFSAHLLPLVARLCLVPLETIVFINRFAMIFTGLEVLYFIASNLLVPY 195
            :||||||||||:|:||||||||:|||:||||||||||||.||:|||||||||||||:.|||||||
Human   161 LVVCTLCSCVMKTKQIWLFSAHMLPLLARLCLVPLETIVIINKFAMIFTGLEVLYFLGSNLLVPY 225

Zfish   196 NLAKTAYRELVQVVEVYGLLALGMSLWNQLVLPVLFMCFWLVLFALQIYTYFSTRDQPPSRERLL 260
            ||||:||||||||||||||||||||||||||:|||||.|||||||||||:||||||||.||||||
Human   226 NLAKSAYRELVQVVEVYGLLALGMSLWNQLVVPVLFMVFWLVLFALQIYSYFSTRDQPASRERLL 290

Zfish   261 FLFLTSIAECCSTPYSLLGLVFTVSFVALGVLTLCKFYLQGYRAFMNDNAMHRGMTEGITLLILA 325
            ||||||||||||||||||||||||||||||||||||||||||||||||.||:||||||:||||||
Human   291 FLFLTSIAECCSTPYSLLGLVFTVSFVALGVLTLCKFYLQGYRAFMNDPAMNRGMTEGVTLLILA 355

Zfish   326 VQTGLIELQVIHRAFLLSIILFIVVASILQSMLEIADPIVLALGASRDKSLWKHFRAVSLCLFLL 390
            ||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||
Human   356 VQTGLIELQVVHRAFLLSIILFIVVASILQSMLEIADPIVLALGASRDKSLWKHFRAVSLCLFLL 420

Zfish   391 VFPAYMAYMICQFFRMDFWLLIIISSSILTSLQVLGTLLIYVLFMVEEFRKAPVENMDEVIYYVN 455
            ||||||||||||||.|||||||||||||||||||||||.||||||||||||.||||||:||||||
Human   421 VFPAYMAYMICQFFHMDFWLLIIISSSILTSLQVLGTLFIYVLFMVEEFRKEPVENMDDVIYYVN 485

Zfish   456 GTYRLLEFLVAVCVVAYGVSETLFGEWTVMGSTIILVHSYYNVWLRAQLGWQSFLLRRDAVHKIQ 520
            |||||||||||:||||||||||:|||||||||.||.:||||||||||||||:|||||||||:||:
Human   486 GTYRLLEFLVALCVVAYGVSETIFGEWTVMGSMIIFIHSYYNVWLRAQLGWKSFLLRRDAVNKIK 550

Zfish   521 SMPTASTLQLQQHNDICSICFQDMKSAVITPCSHFFHAACLKKWLYVQETCPLCHGQLKSQLQPT 585
            |:|.|:..||::|||||:||:|||||||||||||||||.||||||||||||||||..||:..|
Human   551 SLPIATKEQLEKHNDICAICYQDMKSAVITPCSHFFHAGCLKKWLYVQETCPLCHCHLKNSSQ-- 613

Zfish   586 SSPGTPTQGT--PAANQNPREVEQEQRQPQVELNTEEGIRAEE 626
             .||..|:..  |.|......:.||..:|..:.:| .|.|.:|
Human   614 -LPGLGTEPVLQPHAGAEQNVMFQEGTEPPGQEHT-PGTRIQE 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rnf145b	NP_956057.1	TRC8_N	8..506	CDD:463960	451/497 (91%)
		RING-H2_RNF145	533..575	CDD:319598	38/41 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	582..685		13/47 (28%)
RNF145	NP_001186309.1	TRC8_N	38..536	CDD:463960	451/497 (91%)
		HRD1	<550..>655	CDD:227568	60/109 (55%)
		RING-H2_RNF145	563..605	CDD:319598	38/41 (93%)