DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TTLL1A and TTLL2

DIOPT Version :9

Sequence 1:	NP_573197.2	Gene:	TTLL1A / 32704	FlyBaseID:	FBgn0030823	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_114155.4	Gene:	TTLL2 / 83887	HGNCID:	21211	Length:	592	Species:	Homo sapiens

Alignment Length:	400	Identity:	137/400 - (34%)
Similarity:	200/400 - (50%)	Gaps:	71/400 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 PEVKLITQPINGLHYIRNRLRPPKSRNGIYYSTDWDKSALV-SNFQKRGW--LQVPSFNGE-WNF 88
            |.:....:|...|      |:|      :.:..|....|:| |...:|||  ......|.| ||.
Human    71 PHLMAEDEPSGAL------LKP------LVFRVDETTPAVVQSVLLERGWNKFDKQEQNAEDWNL 123

  Fly    89 YWACTQNCRYIFGIDHPYRMRSDQVINHFPNSIELSRKDLLIKNIKRYRKDLERRGDPLAQSHPP 153
            ||..:.     |.:.....::..|.:||.|.:.:|:|||.|.|::|..|:   ..|..|.|
Human   124 YWRTSS-----FRMTEHNSVKPWQQLNHHPGTTKLTRKDCLAKHLKHMRR---MYGTSLYQ---- 176

  Fly   154 DTKLGIGGTRYKHLDIIPMTFVLPSDYQMFV-EVFHRNPA-----STWIVKPCSKSQGVGIYLVN 212
                           .||:|||:|:||..|| |.|.....     |.||.||...|:|.||.:
Human   177 ---------------FIPLTFVMPNDYTKFVAEYFQERQMLGTKHSYWICKPAELSRGRGILI-- 224

  Fly   213 KLSKLKKFAYDARTFYPQINRDTCVISKYIDNPLLIGGKKFDLRLFVLVTTFNPLKAYLYKEGFC 277
             .|..|.|.:|          |..::.|||.||||||..|.|||::|.||.|.||..|:|:||..
Human   225 -FSDFKDFIFD----------DMYIVQKYISNPLLIGRYKCDLRIYVCVTGFKPLTIYVYQEGLV 278

  Fly   278 RFCTEKYDETEIDNVFMHLTNVSIQKTNQEYNSI-----HGGKWPLQNLWLYLDSLRGEGVSD-M 336
            ||.|||:|.:.:.|.:.||||.||.|:...|..|     ||.||.|...:.|   ||...|.| :
Human   279 RFATEKFDLSNLQNNYAHLTNSSINKSGASYEKIKEVIGHGCKWTLSRFFSY---LRSWDVDDLL 340

  Fly   337 LWSRITATIRHSLDAVAPVMANDRHCFEVYGYDIIIDNNLKPWLIEINTSPSMHSTTTNDRMLKS 401
            ||.:|...:..::.|:||.:....:|||::|:||:||:||||||:|:|.||::....:.|.::|.
Human   341 LWKKIHRMVILTILAIAPSVPFAANCFELFGFDILIDDNLKPWLLEVNYSPALTLDCSTDVLVKR 405

  Fly   402 RLIDNVLDVV 411
            :|:.:::|::
Human   406 KLVHDIIDLI 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL1A	NP_573197.2	TTL	107..419	CDD:281171	118/316 (37%)
TTLL2	NP_114155.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..77		1/5 (20%)
		TTL	140..412	CDD:281171	117/309 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2157
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001326
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810