DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TTLL1A and ttll6

DIOPT Version :9

Sequence 1:	NP_573197.2	Gene:	TTLL1A / 32704	FlyBaseID:	FBgn0030823	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001098994.1	Gene:	ttll6 / 564075	ZFINID:	ZDB-GENE-080107-1	Length:	778	Species:	Danio rerio

Alignment Length:	400	Identity:	120/400 - (30%)
Similarity:	178/400 - (44%)	Gaps:	89/400 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 EWNFYWACTQNCRYIFGIDHPYRMRSDQVINHFPNSIELSRKDLLIKNIKRYRKDLERRGDPLAQ 149
            :|..||.   :|.  ..:|....|:..|.|||||...|:.|||||.:|:.|..|...
Zfish    83 DWTLYWT---DCS--VSLDRVMDMKRYQKINHFPGMNEICRKDLLARNMNRMLKLFP-------- 134

  Fly   150 SHPPDTKLGIGGTRYKHLDIIPMTFVLPSDYQMFVEVFHRNPASTWIVKPCSKSQGVGIYLVNKL 214
                           |..:|.|.|:.||:||..|..........|:|.||.|..||.|||| .|.
Zfish   135 ---------------KEYNIFPRTWCLPADYSDFQAYTRAKKHKTFICKPDSGCQGRGIYL-TKS 183

  Fly   215 SKLKKFAYDARTFYPQINRDTCVISKYIDNPLLIGGKKFDLRLFVLVTTFNPLKAYLYKEGFCRF 279
            ||      |.|.....|    |.:  |:..|.:|.|.|||||::||||:.:|.:.::|.||..||
Zfish   184 SK------DIRPGEHMI----CQV--YMSKPFIIDGFKFDLRIYVLVTSCDPFRVFMYDEGLVRF 236

  Fly   280 CTEKYDETEIDN---VFMHLTNVSIQKTNQEY--NSIHGGKWPLQNLWLYLDSLRGEGVSDMLWS 339
            ||..|.|..:.|   |.|||||.:|.|.::.:  :...|.|..|.:...:::.:..:  ::.||:
Zfish   237 CTTHYTEPTVSNLEDVCMHLTNYAINKHSENFVRDEDTGSKRKLSSFKKHMEDMSYD--TEKLWT 299

  Fly   340 RITATI-----------RHSLDAVAPVMANDRHCFEVYGYDIIIDNNLKPWLIEINTSPSMHSTT 393
            .|...|           :|:.....|..|:...|||:.|:|:::|..|||||:|:|.|||..:.:
Zfish   300 DIEDAIIKTLISAHPILKHNYQTCFPNHASGSACFEILGFDVLLDRRLKPWLLEVNHSPSFTTDS 364

  Fly   394 TNDRMLKSRLIDNVLDVVVPPNCMPNEHWDKTPNPELLKNFTVLMPISPC---KPKEQVPVRRKG 455
            ..||.:|..|:.:.|                           ||:.:..|   |..|:...|.|.
Zfish   365 RLDREVKDSLLYDTL---------------------------VLINLGACDRRKITEEEKRRVKE 402

  Fly   456 RLSKKKKSKS 465
            ||.:.:..::
Zfish   403 RLQQNRSREA 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL1A	NP_573197.2	TTL	107..419	CDD:281171	106/327 (32%)
ttll6	NP_001098994.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43
		TTL	99..379	CDD:281171	105/317 (33%)
		c-MTBD region. /evidence=ECO:0000250\|UniProtKB:Q8N841	365..445		14/74 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	402..422		2/10 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	485..542
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..778
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910