DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TTLL1A and Ttll1

DIOPT Version :9

Sequence 1:	NP_573197.2	Gene:	TTLL1A / 32704	FlyBaseID:	FBgn0030823	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001344882.1	Gene:	Ttll1 / 319953	MGIID:	2443047	Length:	423	Species:	Mus musculus

Alignment Length:	436	Identity:	217/436 - (49%)
Similarity:	297/436 - (68%)	Gaps:	43/436 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 IYYSTDWDKSALVSNFQKRGWLQVPSFNGEWNFYWACTQNCRYIFGIDHPYRMRSDQVINHFPNS 120
            :.:.||.:||.|::||:||||:||.. |.:|||||...|..|.:|.::..||:..||::|||||.
Mouse     5 VKWVTDIEKSVLINNFEKRGWIQVTE-NEDWNFYWMSVQTIRNVFSVETGYRLSDDQIVNHFPNH 68

  Fly   121 IELSRKDLLIKNIKRYRKDLERRGDPLAQSHPPDTKLGIGGTRYKHLDIIPMTFVLPSDYQMFVE 185
            .||:||||::||||||||:||:.|.|||:...        ..:|.:||.:|:|::||:||.:|||
Mouse    69 YELTRKDLMVKNIKRYRKELEKEGSPLAEKDE--------NGKYLYLDFVPVTYMLPADYNLFVE 125

  Fly   186 VFHRNPASTWIVKPCSKSQGVGIYLVNKLSKLKKFAYDART--FYPQINRDTCVISKYIDNPLLI 248
            .|.::|:||||:|||.|:||.||:|:||||::||::.|::|  |..|..::..|||.||:|||||
Mouse   126 EFRKSPSSTWIMKPCGKAQGKGIFLINKLSQIKKWSRDSKTSSFVSQSTKEAYVISVYINNPLLI 190

  Fly   249 GGKKFDLRLFVLVTTFNPLKAYLYKEGFCRFCTEKY--DETEIDNVFMHLTNVSIQKTNQEYNSI 311
            ||:||||||:|||:|:.||:.|:||.|||||||.||  ..:|:||:|:|||||:|||..::||.|
Mouse   191 GGRKFDLRLYVLVSTYRPLRCYMYKLGFCRFCTVKYTPSTSELDNMFVHLTNVAIQKHGEDYNHI 255

  Fly   312 HGGKWPLQNLWLYLDSLRGEGVSDMLWSRITATIRHSLDAVAPVMANDRHCFEVYGYDIIIDNNL 376
            |||||.:.||.|||:|.||..|:..|:..|...|..||.||||||.||:||||.||||||||:.|
Mouse   256 HGGKWTVNNLRLYLESTRGREVTSKLFDEIHWIIVQSLKAVAPVMNNDKHCFECYGYDIIIDDKL 320

  Fly   377 KPWLIEINTSPSMHSTTTNDRMLKSRLIDNVLDVVVPPNCMPNEHWDKTPNPELLKNFTVL---- 437
            ||||||:|.|||:.|:|.|||:||..||::.|::.||...:|:..|:|:|..|:|.|:.:|
Mouse   321 KPWLIEVNASPSLTSSTANDRILKYNLINDTLNIAVPNGEIPDCKWNKSPPKEVLGNYEILYDEE 385

  Fly   438 ----------------MPISPCKPKEQVPVRRKGRLSKKKKSKSTT 467
                            .|:.|          |.||.....:|..||
Mouse   386 LAQGDGAERELRNRPGQPVGP----------RAGRSRDSGRSVLTT 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL1A	NP_573197.2	TTL	107..419	CDD:281171	178/315 (57%)
Ttll1	NP_001344882.1	TTL	59..364	CDD:281171	178/312 (57%)
Ttll1	NP_001344882.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	390..423		8/42 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830710
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2157
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57390
OrthoDB	1	1.010	-	-		D315374at33208
OrthoFinder	1	1.000	-	-		FOG0001326
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12241
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1567
SonicParanoid	1	1.000	-	-		X4704
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.850