DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TTLL1A and Ttll10

DIOPT Version :9

Sequence 1:	NP_573197.2	Gene:	TTLL1A / 32704	FlyBaseID:	FBgn0030823	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001164004.1	Gene:	Ttll10 / 298692	RGDID:	1560839	Length:	727	Species:	Rattus norvegicus

Alignment Length:	513	Identity:	123/513 - (23%)
Similarity:	219/513 - (42%)	Gaps:	86/513 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 QKCGGSCTSDDDLPEVKLITQPINGLHYIRNRLRPPKSRNGI---------------YYSTDWDK 64
            :|..||...:...||:..:.|..:.|........|..|.||:               :|....:.
  Rat   167 EKRMGSSVEEGLRPELSQLEQDADNLGEEEAARLPVTSLNGLLMEGDRHPNPGQGPFFYIGGTNG 231

  Fly    65 SALVSNF-QKRGWLQVPSFNGE-WNFYWACTQNCRYIFGIDHPYRMR-SDQVINHFPNSIELSRK 126
            ::::||: :.:||.:......| :...| |...||     |:....| ..|::...||:..|:.|
  Rat   232 ASIISNYCESKGWQRTQDSRCEDYKLKW-CEIKCR-----DNYCSFREGQQLLFQLPNNKLLTTK 290

  Fly   127 DLLIKNIKRYRKDLERRGDPLAQSHPPDTKLGIGGTRYKHL---DIIPMTFVLP--SDYQMFVEV 186
            ..|:..::.:.:.|.:     |:..|        .|:.|.|   :..|.|:.|.  .:.|.|..:
  Rat   291 IGLLSALREHARTLSK-----ARLMP--------STQAKVLKMDEFFPETYRLDIRDERQAFFTL 342

  Fly   187 FHRNPASTWIVKPCSKSQGVGIYLVNKLSKLKKFAYDART-------FY-------PQINRDTCV 237
            |  :....||.||.:.:||.||:|:.  |:.:..|..|:|       .|       ||..    |
  Rat   343 F--DETQMWICKPTASNQGKGIFLIR--SQEEAAALQAKTQSIEDDPIYRKMPFRAPQAR----V 399

  Fly   238 ISKYIDNPLLIGGKKFDLRLFVLVTTFNPLKAYLYKEGFCRFCTEKYDETEIDNVFMHLTNVSIQ 302
            :.:|:.||||:.|||||:|.::|:....|...: :..|:.|.....|:....| :..||||..:|
  Rat   400 VQRYVQNPLLLDGKKFDVRSYMLIACAMPYMVF-FGHGYARLTLSLYNPHSSD-LSGHLTNQFMQ 462

  Fly   303 KTNQEYNSIHGGK-WPLQNLWLYL-DSLR-GEGV-SDMLWSRITATIRHSLDAVAPVMANDRHC- 362
            |.:..|..:.... |.:::|..|: |..| .:|: .|.:::..|..::..:......:.:...|
  Rat   463 KKSPLYMLLKDSTVWSMEHLNRYINDKFRKSKGLPRDWVFTTFTKRMQQIMSHCFLAVKSKLECK 527

  Fly   363 ---FEVYGYDIIIDNNLKPWLIEINTSPSMHSTTTNDRMLKS---RLIDNVLDVVVPPNCMPNEH 421
               |::.|.|.:||.|.|.||:|:|::|::|   ||..:||.   .::...||:.: ..|..:.|
  Rat   528 LGYFDLIGCDFLIDENFKVWLLEMNSNPALH---TNCEVLKEVIPGVVMETLDLAL-ETCQKSLH 588

  Fly   422 WDKTPNPELLKNFTVL-----MPISPCKPKEQVPVRRKGRLSKKKKSKSTTASSGICS 474
            ..|....:..:.|.:|     ..:.|.....:.|:|.....|...:|....:||.:.|
  Rat   589 SQKMLPLQSQRRFVLLYNGETTDLWPRLGSSRPPIRLPYANSNHARSTCEISSSSLTS 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL1A	NP_573197.2	TTL	107..419	CDD:281171	89/342 (26%)
Ttll10	NP_001164004.1	ATP-grasp_4	276..576	CDD:302634	85/325 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2157
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810