Protein Alignment TTLL1A and TTLL3

DIOPT Version :10

• Sequence 1: NP_573197.2
• Gene: TTLL1A / 32704
• FlyBaseID: FBgn0030823
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_001021100.3
• Gene: TTLL3 / 26140
• HGNCID: 24483
• Length: 915
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 134/503 - (26%)
• Similarity: 208/503 - (41%)
• Gaps: 124/503 - (24%)

  Fly    63 DKSALVSNFQKRGWLQVPS------FNGEWNFY--WACTQNCRYIFGIDHPYRMRSDQVINHFPN 119
            ||.|.:.:|    ||....      ...||..|  .|..:...   |...|.:...:.|:.. |.
Human   281 DKKAFIEDF----WLTAARNVLKLVVKSEWKSYPIQAVEEEAS---GDKQPKKQEKNPVLVS-PE 337

  Fly   120 SIE--LSRKDLLIKNIKR--YRKDLERRGDPLAQSHPPDTKLGI--------GGTRYKHLD---- 168
            .::  |...:..:.|:..  ..||||.   ||..: |....|.:        .|...:|||
Human   338 FVDEALCACEEYLSNLAHMDIDKDLEA---PLYLT-PEGWSLFLQRYYQVVHEGAELRHLDTQVQ 398

  Fly   169 -----IIPMTFVLPSDYQMFVEVFHRNPASTWIVKPCSKSQGVGIYLVNKLSKLKKFAYDARTFY 228
                 :..:..|:|       ::......:.|||||.:||:|.||..::.|.::.|..    ...
Human   399 RCEDILQQLQAVVP-------QIDMEGDRNIWIVKPGAKSRGRGIMCMDHLEEMLKLV----NGN 452

  Fly   229 PQINRD-TCVISKYIDNPLLIGGKKFDLRLFVLVTTFNPLKAYLYKEGFCRFCTEKYDETEIDNV 292
            |.:.:| ..|:.|||:.||||.|.|||||.:.|||.:|||..:.|::.:.||.|:.:....:||
Human   453 PVVMKDGKWVVQKYIERPLLIFGTKFDLRQWFLVTDWNPLTVWFYRDSYIRFSTQPFSLKNLDN- 516

  Fly   293 FMHLTNVSIQKTNQEYNSIHGGKWPL---QNLW---LYLDSLRGEGVSDMLWSRITA-----TIR 346
            .:||.|.||||..:  ||.|  :.||   .|:|   .:...|:..|..: .||.|..     .:.
Human   517 SVHLCNNSIQKHLE--NSCH--RHPLLPPDNMWSSQRFQAHLQEMGAPN-AWSTIIVPGMKDAVI 576

  Fly   347 HSLDAVAPVMANDRHCFEVYGYDIIIDNNLKPWLIEINTSPSM-HSTTTNDRMLKSRLIDN---V 407
            |:|......:...:..||:||.|.:...:.:|||||||.||:| .||....|:......|.   |
Human   577 HALQTSQDTVQCRKASFELYGADFVFGEDFQPWLIEINASPTMAPSTAVTARLCAGVQADTLRVV 641

  Fly   408 LDVVVPPNCMPN--EHWDKTPNPE---------LLKNFTVLMPISPC------KP---------- 445
            :|.::..||...  |...|.|..|         |::.||:..|::.|      :|
Human   642 IDRMLDRNCDTGAFELIYKQPAVEVPQYVGIRLLVEGFTIKKPMAMCHRRMGVRPAVPLLTQRGS 706

  Fly   446 ------------KEQVP----VRRKGRLSKKKKSK-------STTASS 470
                        |.|:|    :|.:|::.:::.||       |||..:
Human   707 GEARHHFPSLHTKAQLPSPHVLRHQGQVLRRQHSKLVGTKALSTTGKA 754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTLL1A	NP_573197.2	TTL	107..419	CDD:397308	102/348 (29%)
TTLL3	NP_001021100.3	TTL	356..648	CDD:397308	96/312 (31%)