DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TTLL1A and TTLL1

DIOPT Version :9

Sequence 1:	NP_573197.2	Gene:	TTLL1A / 32704	FlyBaseID:	FBgn0030823	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_036395.1	Gene:	TTLL1 / 25809	HGNCID:	1312	Length:	423	Species:	Homo sapiens

Alignment Length:	386	Identity:	210/386 - (54%)
Similarity:	289/386 - (74%)	Gaps:	13/386 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 IYYSTDWDKSALVSNFQKRGWLQVPSFNGEWNFYWACTQNCRYIFGIDHPYRMRSDQVINHFPNS 120
            :.:.||.:||.|::||:||||:||.. |.:|||||...|..|.:|.::..||:..||::|||||.
Human     5 VKWVTDIEKSVLINNFEKRGWVQVTE-NEDWNFYWMSVQTIRNVFSVEAGYRLSDDQIVNHFPNH 68

  Fly   121 IELSRKDLLIKNIKRYRKDLERRGDPLAQSHPPDTKLGIGGTRYKHLDIIPMTFVLPSDYQMFVE 185
            .||:||||::||||||||:||:.|.|||:...        ..:|.:||.:|:|::||:||.:|||
Human    69 YELTRKDLMVKNIKRYRKELEKEGSPLAEKDE--------NGKYLYLDFVPVTYMLPADYNLFVE 125

  Fly   186 VFHRNPASTWIVKPCSKSQGVGIYLVNKLSKLKKFAYDART--FYPQINRDTCVISKYIDNPLLI 248
            .|.::|:||||:|||.|:||.||:|:||||::||::.|::|  |..|.|::..|||.||:|||||
Human   126 EFRKSPSSTWIMKPCGKAQGKGIFLINKLSQIKKWSRDSKTSSFVSQSNKEAYVISLYINNPLLI 190

  Fly   249 GGKKFDLRLFVLVTTFNPLKAYLYKEGFCRFCTEKY--DETEIDNVFMHLTNVSIQKTNQEYNSI 311
            ||:||||||:|||:|:.||:.|:||.|||||||.||  ..:|:||:|:|||||:|||..::||.|
Human   191 GGRKFDLRLYVLVSTYRPLRCYMYKLGFCRFCTVKYTPSTSELDNMFVHLTNVAIQKHGEDYNHI 255

  Fly   312 HGGKWPLQNLWLYLDSLRGEGVSDMLWSRITATIRHSLDAVAPVMANDRHCFEVYGYDIIIDNNL 376
            |||||.:.||.|||:|.||:.|:..|:..|...|..||.||||||.||:||||.||||||||:.|
Human   256 HGGKWTVSNLRLYLESTRGKEVTSKLFDEIHWIIVQSLKAVAPVMNNDKHCFECYGYDIIIDDKL 320

  Fly   377 KPWLIEINTSPSMHSTTTNDRMLKSRLIDNVLDVVVPPNCMPNEHWDKTPNPELLKNFTVL 437
            ||||||:|.|||:.|:|.|||:||..||::.|::.||...:|:..|:|:|..|:|.|:.:|
Human   321 KPWLIEVNASPSLTSSTANDRILKYNLINDTLNIAVPNGEIPDCKWNKSPPKEVLGNYEIL 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL1A	NP_573197.2	TTL	107..419	CDD:281171	179/315 (57%)
TTLL1	NP_036395.1	TTL	59..364	CDD:397308	179/312 (57%)
TTLL1	NP_036395.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	391..423
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140737
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2157
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57390
OrthoDB	1	1.010	-	-		D315374at33208
OrthoFinder	1	1.000	-	-		FOG0001326
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12241
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1567
SonicParanoid	1	1.000	-	-		X4704
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.850