DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TTLL1A and TTLL10

DIOPT Version :9

Sequence 1:	NP_573197.2	Gene:	TTLL1A / 32704	FlyBaseID:	FBgn0030823	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001123517.1	Gene:	TTLL10 / 254173	HGNCID:	26693	Length:	673	Species:	Homo sapiens

Alignment Length:	425	Identity:	101/425 - (23%)
Similarity:	174/425 - (40%)	Gaps:	94/425 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 PPKSRNG-IYYSTDWDKSALVSNFQK-RGWLQV-PSFNGEWNFYWACTQNCRYIFGIDHPYRMRS 110
            |..:|.| .:|....:.:.::|::.| :||.:: .|...::...| |....|..:|   .:| ..
Human   150 PHSTRPGPFFYIGGSNGATIISSYCKSKGWQRIHDSRRDDYTLKW-CEVKSRDSYG---SFR-EG 209

  Fly   111 DQVINHFPNSIELSRKDLLIKNIKRYRKDLERRGDPLAQSHPPDTKLGIGGTRYKH-----LDII 170
            :|::...||:..|:.|..|:..:         ||...|.|.......|:.....|.     |:.:
Human   210 EQLLYQLPNNKLLTTKIGLLSTL---------RGRARAMSKASKVPGGVQARLEKDAAAPALEDL 265

  Fly   171 PMTF--------------VLPSDYQM--------FVEVFHRNPASTWIVKPCSKSQGVGIYLVNK 213
            |.|.              ..|..|::        |..:|  :....||.||.:.:||.||:|:..
Human   266 PWTSPGYLRPQRVLRMEEFFPETYRLDLKHEREAFFTLF--DETQIWICKPTASNQGKGIFLLRN 328

  Fly   214 LSKLKKFAYDARTFY------------PQINRDTCVISKYIDNPLLIGGKKFDLRLFVLVTTFNP 266
            ..::.......|:..            ||..    |:.:||.||||:.|:|||:|.::|:....|
Human   329 QEEVAALQAKTRSMEDDPIHHKTPFRGPQAR----VVQRYIQNPLLVDGRKFDVRSYLLIACTTP 389

  Fly   267 LKAYLYKEGFCRFCTEKYDETEIDNVFMHLTNVSIQKTNQEYNSI-HGGKWPLQNLWLYLDSLRG 330
            ...: :..|:.|.....||....| :..||||..:||.:..|..: ....|.:::|..|
Human   390 YMIF-FGHGYARLTLSLYDPHSSD-LGGHLTNQFMQKKSPLYMLLKEHTVWSMEHLNRY------ 446

  Fly   331 EGVSDMLW---------------SRITATIRHSLDAVAPVMANDRHCFEVYGYDIIIDNNLKPWL 380
              :||..|               .|:...:.|...|..|.:......|::.|.|.:||:|.|.||
Human   447 --ISDTFWKARGLAKDWVFTTLKKRMQQIMAHCFLAAKPKLDCKLGYFDLIGCDFLIDDNFKVWL 509

  Fly   381 IEINTSPSMHSTTTNDRMLKS---RLIDNVLDVVV 412
            :|:|::|::|   ||..:||.   .::...||:|:
Human   510 LEMNSNPALH---TNCEVLKEVIPGVVIETLDLVL 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL1A	NP_573197.2	TTL	107..419	CDD:281171	88/364 (24%)
TTLL10	NP_001123517.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..132
		PHA03247	<9..99	CDD:223021
		CPSase_L_D2	284..548	CDD:388419	72/277 (26%)
		PRK07764	<568..673	CDD:236090
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	569..673
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2157
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810