DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TTLL1A and Ttll6

DIOPT Version :9

Sequence 1:	NP_573197.2	Gene:	TTLL1A / 32704	FlyBaseID:	FBgn0030823	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_766387.2	Gene:	Ttll6 / 237930	MGIID:	2683461	Length:	822	Species:	Mus musculus

Alignment Length:	424	Identity:	122/424 - (28%)
Similarity:	189/424 - (44%)	Gaps:	78/424 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 TSDDDLPEVK-LITQPINGLHYIRNRLRPPKSRNGIYYSTDWDKSALVSNF------------QK 73
            :|.:||.|:| .:|     |.::|...:........:......|..||.|.            |:
Mouse    19 SSTEDLEELKEFVT-----LAFVRENTQKRLQNAQQHGKKKRKKKRLVINLSNCRYDSVRRAAQQ 78

  Fly    74 RGWLQVPSFNGEWNFYWACTQNCRYIFGIDHPYRMRSDQVINHFPNSIELSRKDLLIKNIKRYRK 138
            .| |:....|.:|..||.     .|...::....|:|.|.|||||...|:.|||||.:|:.|
Mouse    79 YG-LREAGDNDDWTLYWT-----DYSVSLERVMEMKSYQKINHFPGMSEICRKDLLARNMSR--- 134

  Fly   139 DLERRGDPLAQSHPPDTKLGIGGTRYKHLDIIPMTFVLPSDYQMFVEVFHRNPASTWIVKPCSKS 203
                    :.:..|.|            ....|.|:.||:|:.............|:|.||.|..
Mouse   135 --------MLKLFPKD------------FHFFPRTWCLPADWGDLQTYSRTRKNKTYICKPDSGC 179

  Fly   204 QGVGIYLVNKLSKLKKFAYDARTFYPQINRDTCVISKYIDNPLLIGGKKFDLRLFVLVTTFNPLK 268
            ||.||::...:.::|.             .:..:...||..|.:|.|.|||||::||||:.:||:
Mouse   180 QGRGIFITRSVKEIKP-------------GEDMICQLYISKPFIIDGFKFDLRVYVLVTSCDPLR 231

  Fly   269 AYLYKEGFCRFCTEKYDETEIDN---VFMHLTNVSIQKTNQEY--NSIHGGKWPLQNLWLYLDSL 328
            .::|.||..||.|..|....:||   :.|||||.||.|.:..:  ::..|.|..|.....|:.:
Mouse   232 VFVYNEGLARFATTSYSHPNLDNLDEICMHLTNYSINKHSSNFVQDAFSGSKRKLSTFNSYMKT- 295

  Fly   329 RGEGVSDMLWSRITATIRHSLDAVAPVMANDRH-----------CFEVYGYDIIIDNNLKPWLIE 382
            .|..| :.:|..|...|..:|.:..||:.::.|           |||:.|:||::|..|||||:|
Mouse   296 HGYDV-EQIWRGIEDVIIKTLISAHPVIKHNYHTCFPSHTLNSACFEILGFDILLDRKLKPWLLE 359

  Fly   383 INTSPSMHSTTTNDRMLKSRLIDNVLDVVVPPNC 416
            :|.|||..:.:..|:.:|..|:.:.|.::...||
Mouse   360 VNHSPSFSTDSKLDKEVKDSLLYDALVLINLGNC 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL1A	NP_573197.2	TTL	107..419	CDD:281171	102/326 (31%)
Ttll6	NP_766387.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		1/4 (25%)
		TTL	105..385	CDD:281171	99/317 (31%)
		c-MTBD region. /evidence=ECO:0000250\|UniProtKB:Q8N841	371..450		6/23 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	736..772
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	791..822
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910