DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment baz and Pard3

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_006531583.1	Gene:	Pard3 / 93742	MGIID:	2135608	Length:	1337	Species:	Mus musculus

Alignment Length:	1608	Identity:	419/1608 - (26%)
Similarity:	633/1608 - (39%)	Gaps:	524/1608 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 PDSWVTVTHLQ-TQSGILDPDDCVRDVADDREQILAHFDDPGPDPGVPQGGGDGASGSSSVGTGS 125
            |:.|:.|..|: ...||||.||.:.|||||:::::|.||:..     |..||||.| :||.||.|
Mouse    42 PNYWIQVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQD-----PHHGGDGTS-ASSTGTQS 100

  Fly   126 PDIFRDP--TNTEAPTCPRDLSTPHIEVTSTTSGPMAGLGVGLMVRRSSDPNLLASLKAEGSNKR 188
            |:||...  ||..:...|.. :|..||||.:    :....:.|.||||||| .|..|....|:..
Mouse   101 PEIFGSELGTNNVSAFQPYQ-ATSEIEVTPS----VLRANMPLHVRRSSDP-ALTGLSTSVSDNN 159

  Fly   189 WSAAAPHYAGGDSPER-------LFLDKAGGQLSPQWEEDDDPSHQLKEQLLHQQQPHAANGGSS 246
            :|:..|   ...:|.|       |..:.||...:...::|::.....::......|....|..||
Mouse   160 FSSEEP---SRKNPTRWSTTAGFLKQNTAGSPKTCDRKKDENYRSLPRDPSSWSNQFQRDNARSS 221

  Fly   247 SGNHQPFARSGRLSMQFLGDGNGYKWMEAAEKLQNQPPAQQTYQQGSHHAGHGQNGAYSSKSLPR 311
            .....|...               :|:|          .|:..::|:.                .
Mouse   222 LSASHPMVD---------------RWLE----------KQEQDEEGTE----------------E 245

  Fly   312 ESKRKEPLGQAYESIRE------KDGEMLLIINEYGSPLGLTALPDKEHGG---GLLVQHVEPGS 367
            :|.|.||:|.|...:..      .|...|:.:...|.|||:..:|....||   ||||:.:|.|.
Mouse   246 DSSRVEPVGHADTGLENMPNFSLDDMVKLVQVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGG 310

  Fly   368 RAERGRL-RRDDRILEINGIKLIGLTESQVQEQLRRALESSELRVRVL----------------- 414
            :||:..| ..:|.|:.||...|......|.|...|:|     :|.||:
Mouse   311 KAEQENLFHENDCIVRINDGDLRNRRFEQAQHMFRQA-----MRARVIWFHVVPAANKEQYEQLS 370

  Fly   415 RGDRNR----RQQRDSKVAEMVEVATVSP----------------------------TRKPHAAP 447
            :.::|.    |...||.......||..:|                            :.||.|||
Mouse   371 QREKNNYSPGRFSPDSHCVANRSVANNAPQALPRAPRLSQPPEQLDAHPRLPHSAHASTKPPAAP 435

  Fly   448 -------VGTSL-QVANTRKLGRKIEIMLKKGPNGLGFSVTTRDNPAGGHCPIYIKNILPRGAAI 504
                   :.|:: .|.||:|:|:::.|.||||..|||||:|:||...||..|||:||||||||||
Mouse   436 ALAPPSVLSTNVGSVYNTKKVGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAI 500

  Fly   505 EDGRLKPGDRLLEVDGTPMTGKTQTDVVAILRGMPAGATVRIVVSRQQELAEQADQPAEKSAGVA 569
            :|||||.||||:||:|..:.||:|.:||::||......||.::|.||    |:|..|.|.:|
Mouse   501 QDGRLKAGDRLIEVNGVDLAGKSQEEVVSLLRSTKMEGTVSLLVFRQ----EEAFHPREMNA--- 558

  Fly   570 VAPSVAPPAVPAAAAPAPPIPVQKSSSARSLFTHQQQSQLNESQHFIDAGSESAASNDS--LPPS 632
                                               :.||:...:       |:.|.::.  |.|.
Mouse   559 -----------------------------------EPSQMQTPK-------ETKAEDEDVVLTPD 581

  Fly   633 SNSWHSREELTLHIPVHDTEKAGLGVSVKGKTCSNLNASGSSASSGSNGLMKHDGDLGIFVKNVI 697
            .    :||.||..:|::|:..|||||||||                 |...::..|||||||::|
Mouse   582 G----TREFLTFEVPLNDSGSAGLGVSVKG-----------------NRSKENHADLGIFVKSII 625

  Fly   698 HGGAASRDGRLRMNDQLLSVNGVSLRGQNNAEAMETLRRAMVNTPGKHPGTITLLVGRKILRSAS 762
            :|||||:|||||:||||::|||.||.|:.|.||||||||:| :|.|...|.|.|:|.|:|.|.
Mouse   626 NGGAASKDGRLRVNDQLIAVNGESLLGKANQEAMETLRRSM-STEGNKRGMIQLIVARRISRC-- 687

  Fly   763 SSDILDHSNSHSHSHSNSSGGSNSNGSGNNNNSSSNASDNSGATVIYLSPEKREQRCNGGGGGGS 827
                                          |...|..|..:....|....:.||:|.:.....|.
Mouse   688 ------------------------------NELRSPGSPAAPELPIETELDDRERRISHSLYSGI 722

  Fly   828 AGNEMNRWSNPVLDRLTGGICSSNSAQPSSQQSHQQQPHPSQQQQQQRRLPAAPVCSSAALRNES 892
            .|.:.:...|..|.|:.|   .|...|.|...:   .||
Mouse   723 EGLDESPTRNAALSRIMG---ESGKCQLSPTVN---MPH-------------------------- 755

  Fly   893 YYMATNDNWSPAQMHLMTAHGNTALLIEDDAEPMSPTLPARPHDGQHCNTSSANPSQNLAVGNQG 957
                                 :..::||||..|:.|     ||.....::||.:.     ||.
Mouse   756 ---------------------DDTVMIEDDRLPVLP-----PHLSDQSSSSSHDD-----VGF-- 787

  Fly   958 PPINTVPGTPSTSSNFDATYSSQLSLETN-SGVEHFSRDALGRRSISEKHHAALDARETGTYQRN 1021
              |.|..||.:.::..|   |:..||..: ..|..|.|:..||:|:|||              |.
Mouse   788 --IMTEAGTWAKATISD---SADCSLSPDVDPVLAFQREGFGRQSMSEK--------------RT 833

  Fly  1022 KKLREERERERRIQLTKSAVYGGSIESLTARIASANAQFSGYKHAKTASSIEQRETQQQLAAAEA 1086
            |:..:..:.: .::..||       :|:...||.         ..|..:..:||        |.:
Mouse   834 KQFSDASQLD-FVKTRKS-------KSMDLGIAD---------ETKLNTVDDQR--------AGS 873

  Fly  1087 EARDQLGDLGPSLGMKKSSSLESLQTMVQELQMSDEPRGHQAL-RAPRGRGREDSLRAAVVSEPD 1150
            .:|    |:|||||:|||||||||||.|.|:.::.....|:.. |..||||..:|.|||:....|
Mouse   874 PSR----DVGPSLGLKKSSSLESLQTAVAEVTLNGNIPFHRPRPRIIRGRGCNESFRAAIDKSYD 934

  Fly  1151 ASKPRKTWLLEDGD------HEGGFASQRNG-------------PFQSSLN-DGKHGCKSSRAK- 1194
              ||    :::|.|      .|....|.|:|             ..:..:| |.:...|:.|.|
Mouse   935 --KP----MVDDDDEGMETLEEDTEESSRSGRESVSTSSDQPSYSLERQMNGDPEKRDKTERKKD 993

  Fly  1195 -------------------KPSILRGIGHMFRFGKNRKD------GVVPV-DNYAVNISPPTSVV 1233
                               |..:|:|:|.||||||:|||      |.:.: |::.
Mouse   994 KAGKDKKKDREKEKDKLKAKKGMLKGLGDMFRFGKHRKDDKMEKMGRIKIQDSFT---------- 1048

  Fly  1234 STATSPQLQQQQQQQLQQHQQQQQIPTAALAALERNGKPPAYQPPPPLPAPNGVGSNGIHQNDIF 1298
                      .::.:::..::|::|........||..
Mouse  1049 ----------SEEDRVRMKEEQERIQAKTREFRERQA---------------------------- 1075

  Fly  1299 NHRYQHYANYEDLHQQH--QQHQISGGDSTTSISETLSE--------STLECMRQQVIRQRIKVE 1353
              |.:.||..:|.|:..  ....:.||.|:......|:.        ..::.:..||.:.|....
Mouse  1076 --RERDYAEIQDFHRTFGCDDELLYGGMSSYEGCLALNARPQSPREGHLMDTLYAQVKKPRSSKP 1138

  Fly  1354 AESRR-----HQHYHS-----QRSARSQDV-SMHSTSSGSQPGSLAQPQAQSNGVRPMSSYYEYE 1407
            .:|.|     |.....     |::.:.:|| ....|.|..|..|.::|.:|| |...:|...:.:
Mouse  1139 GDSNRSTPSNHDRIQRLRQEFQQAKQDEDVEDRRRTYSFEQSWSSSRPASQS-GRHSVSVEVQVQ 1202

  Fly  1408 TVQQQRVGSIKHS---HSSSATSS--SSSPINVPHWKAAAMNGYSPASLNSSAR----------S 1457
            ..:|:...|.:.:   :||....|  ::|.|:...|:    ..|:|.....||:          |
Mouse  1203 RQRQEERESFQQAQRQYSSLPRQSRKNASSISQDSWE----QNYAPGEGFQSAKENPRYSSYQGS 1263

  Fly  1458 RGPFV------------TQVTIREQSSGGIPAHLLQQHQQQQLQQQQP 1493
            |..::            ||..:|::          |:.::|||::|.|
Mouse  1264 RNGYLGGHGFNARVMLETQELLRQE----------QRRKEQQLKKQPP 1301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873	46/114 (40%)
		PDZ_signaling	341..412	CDD:238492	26/74 (35%)
		CRS1_YhbY	<390..>436	CDD:294440	12/66 (18%)
		PDZ_signaling	462..548	CDD:238492	49/85 (58%)
		PDZ_signaling	<686..753	CDD:238492	43/66 (65%)
Pard3	XP_006531583.1	DUF3534	2..83	CDD:338230	18/40 (45%)
		PDZ_signaling	272..347	CDD:238492	25/74 (34%)
		PDZ_signaling	465..544	CDD:238492	47/78 (60%)
		PDZ_signaling	588..681	CDD:238492	56/110 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850036
Domainoid	1	1.000	103	1.000	Domainoid score	I6774
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	327	1.000	Inparanoid score	I2449
Isobase	1	0.950	-	0.946395	Normalized mean entropy	S7653
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D387987at33208
OrthoFinder	1	1.000	-	-		FOG0002688
OrthoInspector	1	1.000	-	-		otm44252
orthoMCL	1	0.900	-	-		OOG6_107739
Panther	1	1.100	-	-	O	PTHR16484
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2708
SonicParanoid	1	1.000	-	-		X2449
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.830