DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment baz and SLC9A3R1

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	NP_004243.1	Gene:	SLC9A3R1 / 9368	HGNCID:	11075	Length:	358	Species:	Homo sapiens

Alignment Length:	340	Identity:	96/340 - (28%)
Similarity:	137/340 - (40%)	Gaps:	88/340 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   338 NEYGSPLGLTALPDKEHGG----GLLVQHVEPGSRAERGRLRRDDRILEINGIKLIGLTESQVQE 398
            |.||..|         ||.    |..::.|||||.||:..|...||::|:||..:...|..||..
Human    22 NGYGFHL---------HGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVS 77

  Fly   399 QLRRALESSELRVRVLRGDRNRRQQRDSKVAEMVEVATVSPTRKPHAA--PVGTSLQVANTRKLG 461
            ::|.||.:    ||:|..|....:|. .|:...|....:.....|..|  |....:|.|......
Human    78 RIRAALNA----VRLLVVDPETDEQL-QKLGVQVREELLRAQEAPGQAEPPAAAEVQGAGNENEP 137

  Fly   462 RKIE-------------IMLKKGPNGLGFSVTTRDNPAGGHCPIYIKNILPRGAAIEDGRLKPGD 513
            |:.:             ..:||||:|.||::.:..:..|.    :|:::.|...|...| |:..|
Human   138 READKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSKPGQ----FIRSVDPDSPAEASG-LRAQD 197

  Fly   514 RLLEVDGTPMTGKTQTDVVAILRGMPAGA--TVRIVVSRQQELAEQADQPAEKSAGVAVAPSV-- 574
            |::||:|..|.||...|||:.:|   ||.  |..:||.|      :.|:..:|   ..|.||.
Human   198 RIVEVNGVCMEGKQHGDVVSAIR---AGGDETKLLVVDR------ETDEFFKK---CRVIPSQEH 250

  Fly   575 --APPAVP---------------AAAAPAPPIP--VQKSSSARSLFTHQQQSQLNESQHFIDAGS 620
              .|..||               |.||...|.|  |:.:||..|       .:||        ..
Human   251 LNGPLPVPFTNGEIQKENSREALAEAALESPRPALVRSASSDTS-------EELN--------SQ 300

  Fly   621 ESAASNDSLPPSSNS 635
            :|....||..|||.|
Human   301 DSPPKQDSTAPSSTS 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873
		PDZ_signaling	341..412	CDD:238492	24/74 (32%)
		CRS1_YhbY	<390..>436	CDD:294440	13/45 (29%)
		PDZ_signaling	462..548	CDD:238492	29/100 (29%)
		PDZ_signaling	<686..753	CDD:238492
SLC9A3R1	NP_004243.1	PDZ_signaling	12..91	CDD:238492	29/81 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	114..192		17/81 (21%)
		PDZ_signaling	152..231	CDD:238492	28/86 (33%)
		EBP50_C	235..358	CDD:312529	26/99 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	277..358		16/54 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810