DRSC/TRiP Functional Genomics Resources

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Protein Alignment baz and DLG5

DIOPT Version :9

Sequence 1:NP_001036283.1 Gene:baz / 32703 FlyBaseID:FBgn0000163 Length:1520 Species:Drosophila melanogaster
Sequence 2:NP_004738.3 Gene:DLG5 / 9231 HGNCID:2904 Length:1919 Species:Homo sapiens


Alignment Length:1618 Identity:320/1618 - (19%)
Similarity:535/1618 - (33%) Gaps:530/1618 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   127 DIFRDPTNTEAPTCPRDLSTPHIEVTSTTSGPMAGLGVG----LMVRRSSDPNLLASLKAEGSNK 187
            |.|:|.......|.|..|  |.:.:......|....|.|    ::....||....:||.:.|:  
Human    66 DHFQDLRAALEKTQPHLL--PILYLNGVVGPPQPAEGAGSTYSVLSTMPSDSESSSSLSSVGT-- 126

  Fly   188 RWSAAAPHYAGGDSPERLFLDKAGGQLSPQWEEDDDPSHQLK-----EQLLHQQQPHAANGGSSS 247
              :..||      ||..|..|:   |::   |:.::.|.||:     ...|.::...|.:|  ::
Human   127 --TGKAP------SPPPLLTDQ---QVN---EKVENLSIQLRLMTRERNELRKRLAFATHG--TA 175

  Fly   248 GNHQPFARSG----RLSMQFLGDGNGYKWMEAAEKLQNQ---------PPAQQTYQQGSHHAGHG 299
            .:.:|:.|..    ||.:|.:      :.|...:.||||         ..|::|   ..:|..| 
Human   176 FDKRPYHRLNPDYERLKIQCV------RAMSDLQSLQNQHTNALKRCEEVAKET---DFYHTLH- 230

  Fly   300 QNGAYSSKSLPRESKRKEPLGQAYESIREKDGEMLLIINEYGSPLGLTALPDKEHGGGLLVQHVE 364
                  |:.|..:::.|:.:    :.:|.::|::|...|                   ||.|..|
Human   231 ------SRLLSDQTRLKDDV----DMLRRENGQLLRERN-------------------LLQQSWE 266

  Fly   365 PGSR------AERGRLR-RDDRILEINGI-----KLIGLTESQVQ------EQLRR------ALE 405
            ...|      .|.|.|| :..::|:.||.     ||......:::      :.||:      |:.
Human   267 DMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLEVVKKDYDALRKRYSEKVAIH 331

  Fly   406 SSELRVRVLRGDRNRR---------QQRDSKVAEMVEVATVSPTRKPHAAPVGTSLQVANTRKLG 461
            :::|......|:.|:|         ||||:.:....:.|.  ..|:..|.....:...|..:.|.
Human   332 NADLSRLEQLGEENQRLLKQTEMLTQQRDTAIQLQHQCAL--SLRRFEAIHHELNKATAQNKDLQ 394

  Fly   462 RKIEIMLKKGPNGLGFSVTTRDNPAGGHCPIYIKNILPRGAAIEDGRLKPGDR---LLEVDGTPM 523
            .::|::..:........|.|.....        |....|.|...:.:|...:|   :.|:|    
Human   395 WEMELLQSELTELRTTQVKTAKESE--------KYREERDAVYSEYKLIMSERDQVISELD---- 447

  Fly   524 TGKTQTDV--------------------VAILR------GMPAG-ATVRIVVSRQQ--------- 552
              |.||:|                    :..||      .|.|| |...:.:.|:|         
Human   448 --KLQTEVELAESKLKSSTSEKKAANEEMEALRQIKDTVTMDAGRANKEVEILRKQCKALCQELK 510

  Fly   553 ELAEQADQP--------AEKSAGVAVAPSV-------------APPAVPAAAAPAPPIPVQKSSS 596
            |..::||..        .|:...||...|:             |...:..|.........||:..
Human   511 EALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDV 575

  Fly   597 ARSL--FTHQQQSQLNESQHF----IDAGSESAASNDSLPPSSNSWHSREELTLHIPVHDTEKAG 655
            :|.|  ...|.:|||.:...|    ..:..:||...||:     .|.: |.:.......|.:   
Human   576 SRELKELKEQMESQLEKEARFRQLMAHSSHDSAIDTDSM-----EWET-EVVEFERETEDID--- 631

  Fly   656 LGVSVKGKTCSNLNASGSSASSGSNGLMKHDGDLGIFVKNVIHGGAASRDGRLRMNDQLLSVNGV 720
                        |.|.|...:.|.|... ..||.||||..|..|..|  |||||:||.||.:|.|
Human   632 ------------LKALGFDMAEGVNEPC-FPGDCGIFVTKVDKGSIA--DGRLRVNDWLLRINDV 681

  Fly   721 SLRGQNNAEAMETLRRAMVNTPGKHPGTITLLVGRKILRSASSSDILDHSNSHSHSHSNSSGGS- 784
            .|..::..:|:    :|::|  |:  |.|.::|.|:                      .|.||. 
Human   682 DLINKDKKQAI----KALLN--GE--GAINMVVRRR----------------------KSLGGKV 716

  Fly   785 ----NSNGSGNNNNSSSNASDNSGATVIYLSPEKREQRCNGGGGGGSAGNEMNRWSNPVLDRLTG 845
                :.|.||..::..|..:....|.|:..||..:|       |..:.|:.:...:...||..:.
Human   717 VTPLHINLSGQKDSGISLENGVYAAAVLPGSPAAKE-------GSLAVGDRIVAINGIALDNKSL 774

  Fly   846 GICSS--NSAQPSSQQSHQQQPHPSQQQQQQRRLPAAPVCSSAALRNESYYMATNDNWSPAQMH- 907
            ..|.|  .|.|.|...|               .|...|..||.:.:|....:..:|.....:.| 
Human   775 NECESLLRSCQDSLTLS---------------LLKVFPQSSSWSGQNIFENIKDSDKMLSFRAHG 824

  Fly   908 -LMTAHGNTALL---------------IEDDAEPMSPTLPARPHDGQHCNTSSANPSQNLAVGNQ 956
             .:.||....|:               :||..||..|                ...|..|.....
Human   825 PEVQAHNKRNLIQHNNSTQTDIFYTDRLEDRKEPGPP----------------GGSSSFLHKPFP 873

  Fly   957 GPPINTVP-GTPSTSSNFDATYSSQLSLETNSGVEHFSRDALGRR------------SISEKHHA 1008
            |.|:...| ..||.|....:::.|..|.:...|:.    |..|||            .:.|   |
Human   874 GGPLQVCPQACPSASERSLSSFRSDASGDRGFGLV----DVRGRRPLLPFETEVGPCGVGE---A 931

  Fly  1009 ALDARET------GTYQRNKKLREERERERRIQLTKSAVYGGSIESLTARIASANAQFSGYKHAK 1067
            :||..::      ||:.             :..|:.:||               ..:.|.||..|
Human   932 SLDKADSEGSNSGGTWP-------------KAMLSSTAV---------------PEKLSVYKKPK 968

  Fly  1068 TASSI------EQRETQQQL--------AAAEAEARDQLGDLGPSLGMKKSSSLESLQTMVQELQ 1118
            ...||      ::.:|..::        .|...:...:.|.|.|....::|.|::    ....|:
Human   969 QRKSIFDPNTFKRPQTPPKIDYLLPGPGPAHSPQPSKRAGPLTPPKPPRRSDSIK----FQHRLE 1029

  Fly  1119 MSDEPRGHQALRAPRGRGREDSLRAAVVSEPD------ASKPRK-------TWLLE-DGDHEGGF 1169
            .|.|......     |.....|..:|:..:.|      ||.|||       ::..| |||     
Human  1030 TSSESEATLV-----GSSPSTSPPSALPPDVDPGEPMHASPPRKARVRIASSYYPEGDGD----- 1084

  Fly  1170 ASQRNGPFQSSLNDGKHGCKSSRAKKPSILRGIGHMFRFGKNRKDGVVPVDNYAVNISPPTSVVS 1234
                     ||....|..|......:.  :..:|.     |.|:....|  ::...::|   ||.
Human  1085 ---------SSHLPAKKSCDEDLTSQK--VDELGQ-----KRRRPKSAP--SFRPKLAP---VVI 1128

  Fly  1235 TATSPQLQQQQQQQLQQHQQQQQIPTAALAALERNGKPPAYQP--------PPPLPAPNGVGS-- 1289
            .|             |..::|:.:|.:...:.|.....| |.|        ||..|:...||:  
Human  1129 PA-------------QFLEEQKCVPASGELSPELQEWAP-YSPGHSSRHSNPPLYPSRPSVGTVP 1179

  Fly  1290 ---------NGIHQNDIFNHRYQHYANYEDLHQQHQQHQISGGDSTTSISETLSESTLECMRQQV 1345
                     :.|.:|.|:..|               .|::....|..:..:...:.....::.| 
Human  1180 RSLTPSTTVSSILRNPIYTVR---------------SHRVGPCSSPPAARDAGPQGLHPSVQHQ- 1228

  Fly  1346 IRQRIKVEAESRRHQHYHSQRSARSQDVSMHSTSSGSQPGSLAQPQAQSNGVR-PMSSYYEYETV 1409
              .|:.::...|....|...|:....    :|..|.::.||.:..|.::..:: |.:..|....|
Human  1229 --GRLSLDLSHRTCSDYSEMRATHGS----NSLPSSARLGSSSNLQFKAERIKIPSTPRYPRSVV 1287

  Fly  1410 QQQRVGSIKHSHSSSATSSSSSPINVPHWKAAAMN----------GYSPASLNSSARSRGPFVTQ 1464
            ..:| ||:.||..|   :...||:|:....:.:.:          ..:||||....:.| |:|  
Human  1288 GSER-GSVSHSECS---TPPQSPLNIDTLSSCSQSQTSASTLPRIAVNPASLGERRKDR-PYV-- 1345

  Fly  1465 VTIREQSSGGIPAHLLQQHQQQQLQQQQPTYQTVQKMSGPSQYGSAAGSQP--HASKV 1520
                                      ::|.:..|||.|.|......:|.:.  :.|||
Human  1346 --------------------------EEPRHVKVQKGSEPLGISIVSGEKGGIYVSKV 1377

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
bazNP_001036283.1 DUF3534 <62..174 CDD:288873 11/50 (22%)
PDZ_signaling 341..412 CDD:238492 18/94 (19%)
CRS1_YhbY <390..>436 CDD:294440 11/66 (17%)
PDZ_signaling 462..548 CDD:238492 20/115 (17%)
PDZ_signaling <686..753 CDD:238492 27/66 (41%)
DLG5NP_004738.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 98..142 13/56 (23%)
Takusan 130..212 CDD:282652 24/101 (24%)
TPR_MLP1_2 231..353 CDD:285204 28/144 (19%)
COG1340 295..587 CDD:224259 54/307 (18%)
FliJ 310..449 CDD:304890 26/154 (17%)
BAR 417..601 CDD:299863 37/197 (19%)
PDZ_signaling 620..707 CDD:238492 33/112 (29%)
DegQ <702..771 CDD:223343 18/97 (19%)
PDZ_signaling 722..790 CDD:238492 18/74 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 927..1122 46/257 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1150..1187 8/37 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1201..1230 3/31 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1245..1264 4/22 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1271..1306 9/38 (24%)
PDZ 1347..1429 CDD:214570 10/31 (32%)
dbPDZ_assoc 1427..1499 CDD:293216
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1434..1493
PDZ 1499..1582 CDD:214570
SH3_DLG5 1597..1659 CDD:212794
GuKc 1732..1908 CDD:214504
Guanylate_kin 1740..1907 CDD:279019
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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