DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment baz and dlg5

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_004916076.1	Gene:	dlg5 / 779611	XenbaseID:	XB-GENE-978275	Length:	1971	Species:	Xenopus tropicalis

Alignment Length:	1789	Identity:	315/1789 - (17%)
Similarity:	550/1789 - (30%)	Gaps:	591/1789 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 HLQTQSGILDPDDCVRDVAD-------DREQILAHFDDPGPDPGVPQGGGDGASGSSSVGTGSPD 127
            |......|.|.|..:..:.:       |||::                     .||||.|....|
Frog    13 HKNLTESISDADRLLNVLEEAGALTIRDREEL---------------------DGSSSSGQEKVD 56

  Fly   128 I------------FRDPTNTEAPTCPRDLSTPHIEVTSTTSGPMAGLGVGLMVRRSSDPNLLASL 180
            :            |:|.......|.|..||..::....|  |..||....::....||.....||
Frog    57 LLLKMLLVKEKDHFQDLRVALEKTEPHLLSILYLNGLGT--GDTAGSTYSVLTTMPSDSESSGSL 119

  Fly   181 KAEGSNKRWSAAAPHYAGG------------------------------DSPERLFLD-KAGGQL 214
            .:.|:..:.|:..|..|..                              .||...|.| ::..:|
Frog   120 SSIGTTNKPSSPPPTAADSLQVNEKIETILSQLRQVTRERDELRKRLALSSPGSTFDDCRSSPKL 184

  Fly   215 SPQWE-------------------------------EDDDPSHQLKEQLLHQQQPHAANGGSSSG 248
            :|.:|                               ::.|..|.|..::|........:..|...
Frog   185 TPDYERLKVQCMKAMSELEALQSQHAKALKKCEEAAKEADFYHALHSRMLSDHTQLQEDSESMRR 249

  Fly   249 NHQPFARSGRLSMQFLGDGNGYKWMEAAEKLQNQPPAQQ----TYQQGSHHAGHGQNGAYSSKSL 309
            ||....|......|...|   .|.:...::|:.....:|    ..|.||...   .|..|::...
Frog   250 NHAQLQREFSHLQQSCQD---LKHLHETDQLEMSELRRQQQLVVKQNGSSEL---INKLYNTALD 308

  Fly   310 PRESKRKEPLGQAYESIREKDGEMLLIINEYGSPLGLTALPDKEHGG------GLL--------V 360
            ..|..:|:     |:|:|.:..|.   ::.:...||.....::|...      |||        .
Frog   309 KLEGVKKD-----YDSLRRQYNEK---VSSHNLDLGRLEQSEEEKRSLQKQLEGLLKQRENAIHF 365

  Fly   361 QHVEPGSRAERGRLRRDDRI-LEINGIKLIGLTESQVQEQLRR-ALESSELRVRVLRGDRNR--- 420
            ||....|      :||.|.| .|:|.:.   |...::|.::.| ..|::..:...|:..:..
Frog   366 QHQFSSS------MRRYDSIQQELNKVT---LQNKELQREMERLQAEATRFKTMQLKASKEAEKY 421

  Fly   421 RQQRDSKVAEMVEVATVSPTRKPHAAPVGTSLQVA-----NT----RKLGRKIEIMLKKGPNGLG 476
            :::|||...|...:.:...........:.|.|::|     ||    |....::|.:.::    |.
Frog   422 KEERDSVFNEYRLIMSERDQVIKEMDKMQTELELAQGRLKNTSSEKRVASEEMEALRQE----LN 482

  Fly   477 FSVTTRDNPAGGHCPIYIKNILPRGAAIEDGRLKPGDRL---LEVDGTPM---TGKTQTDVV--- 532
            .::..||           ::|..|...:|....:..|:.   .|:|....   |.|.:.||.
Frog   483 SALVERD-----------RSIFERNELLEKYCHEVKDKAEAQKELDQACKDIETVKEERDVARKE 536

  Fly   533 ---AIL------------RGMPAGATV-------RIVVSRQQ------ELAEQADQPA------- 562
               ||:            |.:...||:       .|.|.|:|      ||.| |.|.|
Frog   537 RTEAIIQRDHLLREYYQARQIQDSATLDMERANKEIEVLRKQYEAMSHELKE-ATQEAEVAKCRR 600

  Fly   563 -----EKSAGVAVAPSV-------------APPAVPAAAAPAPPIPVQKSSSARSL------FTH 603
                 |:...||...|:             |...:..|......:..||:.::|.|      ..:
Frog   601 DWAFQERDKIVAERESIRTLCDNLRRERDRAVSELAEALRNLDDMRKQKNDASRELKELKEKMDN 665

  Fly   604 QQQSQLNESQHFIDAGSESAASNDSLPPSSNSWHSREELTLHIPVHDTEKAGLGVSV-------- 660
            |.:.:....|....:..:||...|||     .|.: |.:.......|.:...||..|
Frog   666 QMEKEARFRQLMAHSSHDSAIDTDSL-----EWET-EVVEFERDREDMDLKALGFDVADGVNEPL 724

  Fly   661 -KGKTCSNLNA--SGSSAS------------------------------SGSN------------ 680
             .|::|..:..  .||.|.                              ||..
Frog   725 FPGESCIFVTKVDKGSIADGRLRVNDCLLKINDVDLANKDRKQLLKAVLSGGEVINMVIRRRKSL 789

  Fly   681 ------------GLMKHDG---DLGIFVKNVIHGGAASRDGRLRMNDQLLSVNGVSLRGQNNAEA 730
                        |..|..|   :.|:.|..|:.|..|:::|.|...|:::::||:||..::..|.
Frog   790 GNRIITPLHIHLGSQKDSGISLESGVLVSAVVPGSPAAKEGSLVAGDRVVTINGISLDNKSVMEC 854

  Fly   731 METLRRAMVNTPGKHPGTITLLVGRKIL---RSASSSDILDHSNSHSHSHSNSSGGSNSNGSGNN 792
            ...||....:.      .::||   |::   .|.|..::.::.....|..|.:....|.....||
Frog   855 EALLRNCQESL------NLSLL---KVVPPNTSWSGQNLFENLKESCHVLSPNIHAQNKRNLKNN 910

  Fly   793 NNSSS------------NASDNSGA-TVIYLSPEKREQRCNGGGGG----GSAGNEMNRWSNPV- 839
            :::.:            |..|.:|: ..:.||.....:......||    |...:.::...:|:
Frog   911 SSTQTDIFNPDILECKKNMGDRTGSERALQLSCHSHSEHSLSSLGGEVFMGQGYDILDDGGHPLG 975

  Fly   840 -LDRLTGGICSSNSAQPSS--------QQSHQQ----------------QPHPSQQQQQQRRLPA 879
             .|.:...:..:.:.:.||        ...|.|                .|...::.|...::..
Frog   976 FADTMEDNLVETATGKRSSGTWPKVMVSPGHSQGEFTVFKKPRHRKSIFDPDTFKRPQTPPKISF 1040

  Fly   880 APVCSSAALRNESYYMATNDNWSPAQMHLMTAHGNTALLIEDDAEPMSPTLPARPHD--GQHCNT 942
            .|                     |.|:     .|::....:.:..|..||.|.|...  .:|.:.
Frog  1041 LP---------------------PVQV-----LGHSPQPSKTERPPTPPTPPKRSDSIKFKHRHQ 1079

  Fly   943 SSANPSQNLAVGNQGPPINTVPGTPSTSSNFDATYSSQL-SLETNSGVEHFSRDALGRRSISEKH 1006
            ||:.....:..|:  ||.:..||.....::..|.:|..: |.....|::......:|...:.
Frog  1080 SSSASDSTVTAGS--PPTSPSPGPLPAETSHKAHHSRAIGSCCREDGIDCPLTGCIGTGDVE--- 1139

  Fly  1007 HAALDARETGTYQRNKKLREERERERRIQLTKSAVYGGSIESLTARIASANAQFSGYKHAKTASS 1071
                     |..||.::...:|.|.|            |..:|..|:|..
Frog  1140 ---------GCLQRAEEPELKRARPR------------SAPALRHRLAPV--------------- 1168

  Fly  1072 IEQRETQQQLAAAEAEARDQLGDLGPSLGMKKSSSLESLQTMVQELQMSDEPRGHQALR-APRGR 1135
                                   |.|...::|.|       |..|.::|.| ..|..:| :|...
Frog  1169 -----------------------LIPHYALQKFS-------MNSEERLSPE-LAHDWIRFSPTRS 1202

  Fly  1136 GREDSLRAAVVSEPDAS--KPRK-----------------TW---------------LLEDGDHE 1166
            .|...:.||.:..|..|  .||.                 .|               :.:...|.
Frog  1203 PRHSDIFAASMYGPGMSGTVPRSLAPCPAVTAVLRNPIYTAWSHRVPSNNCPSSANQICQQHLHS 1267

  Fly  1167 GGFASQRNGPFQSSLNDGKHG---CKSSRAKKPSILRGIGHMFRFGKNRKDGV------------ 1216
               ::|.:|.....|:: ||.   |.:||::.|.....:....|.|.:|.:.:
Frog  1268 ---SAQHHGRLSLDLSN-KHPNEFCDTSRSRVPHGSNSLPSSARLGSSRTERIKIPSTPRYPRSS 1328

  Fly  1217 VPVDNYAVN---------ISPPTSVVSTATSPQLQQQQQQQLQQHQQQQQIPTAALAAL---ERN 1269
            |..|..:::         .|||.|.::..||.....|.|..:      ..:|..:::.:   ||.
Frog  1329 VGSDRGSLSHSECSSPSLASPPHSPLNLETSSFASSQSQSSV------ASLPRISVSTVPIGERR 1387

  Fly  1270 GKPPAYQPPPPLPA-----PNGVGSNGIHQNDIFNHRYQHYANYEDLHQQHQQHQISGGDSTTSI 1329
            ...|..:.|..:..     |.|:...|.....||       .:........||..:..||.....
Frog  1388 KDRPLVEEPRHVKVQKGSEPLGISIGGGESGGIF-------VSKVTTGSIAQQAGLEYGDQLLEF 1445

  Fly  1330 SETLSESTLECMRQQVIRQR-----IKVEAESRRHQHYHSQRSARSQDVSMHSTSSGSQPGSLAQ 1389
            :.....:..|...:.:|.|:     |..:......||.||:.|:|....:.|||
Frog  1446 NGINLRNATEQQARLIIGQQCDTITILAQYNPNMCQHIHSRSSSRLDTSTTHST----------- 1499

  Fly  1390 PQAQSNGVRPMSSYYEYETVQQQRVGSIKHSHSSSATSSSSSPINVPHWKAAAMNGYSPASLNSS 1454
              ..|:|.....::...:||.:|..|::  :..|..::.|:||.:.....|..:..:|...:.:.
Frog  1500 --PHSSGAATPDNHSIIDTVSEQDEGTM--TPPSKESTPSTSPCSSLRTNAEGIKRHSELRVVTL 1560

  Fly  1455 ARS-------------RGPFVTQVTIREQSSGGI 1475
            ::|             .|.||..:. .|...||:
Frog  1561 SKSPEKLGIQICGGNLHGIFVLDIE-EENVVGGL 1593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873	24/122 (20%)
		PDZ_signaling	341..412	CDD:238492	19/86 (22%)
		CRS1_YhbY	<390..>436	CDD:294440	9/49 (18%)
		PDZ_signaling	462..548	CDD:238492	20/116 (17%)
		PDZ_signaling	<686..753	CDD:238492	17/69 (25%)
dlg5	XP_004916076.1	CARD	9..88	CDD:260018	19/95 (20%)
		Takusan	127..213	CDD:368141	10/85 (12%)
		Smc	<136..544	CDD:224117	78/445 (18%)
		COG4372	443..>672	CDD:226809	46/244 (19%)
		PDZ_signaling	697..784	CDD:238492	11/86 (13%)
		PDZ_signaling	798..867	CDD:238492	18/74 (24%)
		PDZ	1395..1477	CDD:214570	14/88 (16%)
		dbPDZ_assoc	1475..1554	CDD:374667	20/93 (22%)
		PDZ	1554..1633	CDD:214570	7/41 (17%)
		SH3_DLG5	1649..1711	CDD:212794
		GuKc	1784..1960	CDD:214504
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910