DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment baz and Grip1

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_006514294.1	Gene:	Grip1 / 74053	MGIID:	1921303	Length:	1185	Species:	Mus musculus

Alignment Length:	1327	Identity:	277/1327 - (20%)
Similarity:	411/1327 - (30%)	Gaps:	435/1327 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   250 HQPFARSGRLSMQFLGDGNGYKWMEAAEKLQNQPPAQQTYQQGSHHAGHGQNG---AYSSKS--- 308
            |||  |..:|....|  |..:.|....|....:.|.|...|....|....|..   |.|.|.
Mouse     8 HQP--RGIKLCHSPL--GLPFSWYVRKEFTCCRSPLQPPEQSPCVHFAREQRARMIAVSFKCRCQ 68

  Fly   309 -LPRESKRKEPLGQAYESIREKDGEMLL----------------IINEYGSPLGLTALPDKEHGG 356
             |.|.:|.:.|..::....:..||.:.:                ::.:.|:.||||.....:..|
Mouse    69 ILRRLTKDESPYTKSASQTKPPDGALAVRRQSIPEEFKGSTVVELMKKEGTTLGLTVSGGIDKDG 133

  Fly   357 GLLVQHVEPGSRAERG-RLRRDDRILEINGIKLIGLTESQVQEQLRRALESSELRVRVLRGDRNR 420
            ...|.::..|..|.|. :|...|.|..:|||.|......::...|:...|...|.|.
Mouse   134 KPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVE-------- 190

  Fly   421 RQQRDSKVAEMVEVATVSPTRKPHAAPVGTSLQVANTRKLGRKIEIMLKKGPNGLGFSVTTRDNP 485
                       .|:..||               |..:..:.|.:|:.|.|..|..||.:.
Mouse   191 -----------YELPPVS---------------VQGSSVMFRTVEVTLHKEGNTFGFVIR----- 224

  Fly   486 AGGH------CPIYIKNILPRGAAIEDGRLKPGDRLLEVDGTPMTGKTQTDVVAILR--GMPAGA 542
            .|.|      .|:.|..:.|.|.|..:|.:|||||||.|||..:.|.|..:.::||:  |..|..
Mouse   225 GGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEATL 289

  Fly   543 TVRIVVSRQQELA--------EQADQPAEKSAGVAVAPSVAPPAVPAAAAPAPPIPVQKSSSAR- 598
            .:...||....:|        |.|..|. .|.|||:..||        ......|.:.|..||.
Mouse   290 LIEYDVSVMDSVATASGPLLVEVAKTPG-ASLGVALTTSV--------CCNKQVIVIDKIKSASI 345

  Fly   599 ------------------------------------------SLFTHQQ-----------QSQLN 610
                                                      .:..|.|           :.|.:
Mouse   346 ADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDHVKIQRS 410

  Fly   611 ESQHFIDAGSESAASND--------------------------SLP------------PSSNSWH 637
            :.||..||.    |||.                          :||            |:|.|.:
Mouse   411 DRQHPWDAW----ASNQCGVHTNHHHNTYHPDHCRVPALTFPKALPPNSPPAMVPSSSPTSMSAY 471

  Fly   638 SREEL---TLHIPVHDTEKAGLGVSVKGKTCSNLNASGSSASS--GSNGLMKH----------DG 687
            |...|   ||...::.|...|..:..:.|. .:..:|.|.|||  |..|.:.|          |.
Mouse   472 SLSSLNMGTLPRSLYSTSPRGTMMRRRLKK-KDFKSSLSLASSTVGLAGQVVHTETTEVVLTADP 535

  Fly   688 DLG--------IFVKNVIHG----------GAASRDGRLRMNDQLLSVNGVSLRGQNNAEAMETL 734
            ..|        :|....:..          ..|.|.|.|::.|:::::||:........||.:.|
Mouse   536 VTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEANQLL 600

  Fly   735 RRAMVNT-------------------------PGKH---------------PG------------ 747
            |.:.:.:                         |.||               ||
Mouse   601 RDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHSVELGITISSPSSRKPGDPLVISDIKKGS 665

  Fly   748 ----TITLLVGRKILRSASSSDILDHSNSHSHSHSNSSGGSNSNGSGNNNNSSSNASDNSGATVI 808
                |.||.:|.|:|  |..:..||:.:.....................:..:|:..::||| :|
Mouse   666 VAHRTGTLELGDKLL--AIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDEDNSDEQESSGA-II 727

  Fly   809 YLSPEKREQRCNGGGGGGSAGNEMNRWSNP----VLDRLT-GGICSSNSAQPSSQQSHQQQPHPS 868
            |....||.        ||..|..::....|    ::..|| ||:.....|.....
Mouse   728 YTVELKRY--------GGPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGD---------- 774

  Fly   869 QQQQQQRRLPAAPVCSSAALRNESYYMATNDNWSPAQMHLMTAHGNTALL-IEDDAEPMSPTLPA 932
                   |:.|   .:|::|:.:....|         :||:...|.|..| |:...:..|.:.|.
Mouse   775 -------RILA---INSSSLKGKPLSEA---------IHLLQMAGETVTLKIKKQTDAQSASSPK 820

  Fly   933 R-PHDGQHCNTSSANPSQNLAVGNQGP-PI-----------NTVPGTPST-----SSNFDATYSS 979
            : |..|.         |.:|..|.:.| ||           :|||...|.     .|..||:|.|
Mouse   821 KFPIPGH---------SGDLGDGEEDPSPIQKPGKLSDAYPSTVPSVDSAVDSWDGSGIDASYGS 876

  Fly   980 QLSLETNSGVEHFSRDALGRRSISEKHHAALDARETGTYQRNKKLREERERERRIQLT-----KS 1039
            |.|....||..:                        .||       :.|..::|..|:     :|
Mouse   877 QGSTFQTSGYNY------------------------NTY-------DWRSPKQRTSLSPVPKPRS 910

  Fly  1040 AVY---GGSIESLTARIASANAQFSGYKHAKTASSIEQRETQQQLAAAEAEARDQLGDLGPSLGM 1101
            ..|   |.|.|......|      ||:..|..::..||.|.....|..:.|...|.|.| ..|..
Mouse   911 QTYPDVGLSNEDWDRSTA------SGFVGASDSADAEQEENFWSQALEDLETCGQSGIL-RELEE 968

  Fly  1102 K--KSSSLESLQTMVQELQMSDEPRGHQALRAPRGRGREDSLRAAVVSEPDASK-PRKTWLLEDG 1163
            |  :..||.::..:...:..|.....|:|..|....||:.|.:....|.|..|: .|...|..|
Mouse   969 KADRRVSLRNMTLLATIMSGSTMSLNHEAPMARSQLGRQASFQERSSSRPHYSQTTRSNTLPSD- 1032

  Fly  1164 DHEGGFASQRNGPFQSSLNDGKHGCKSSRAKKPSILRGI-----GHMFRFGKNRKDGVVPVDNYA 1223
                      .|....:|...|...|...:..|..|..:     ..|..||.:..||::....|.
Mouse  1033 ----------VGRKSVTLRKMKQEIKEIMSPTPVELHKVTLYKDSGMEDFGFSVADGLLEKGVYV 1087

  Fly  1224 VNISP--PTSVVSTATSPQLQQQQQQQLQQHQQQQQIPTAALA------ALERNGKPPAYQ---P 1277
            .||.|  |..|.......:|.|....:.:.......:|..|.:      .:.||  |.|.|   .
Mouse  1088 KNIRPAGPGDVGGLKPYDRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLVISRN--PLASQKSIE 1150

  Fly  1278 PPPLPAPNGVGSNGIHQNDIFNHRYQH 1304
            .|.||      |:...||..|..:..|
Mouse  1151 QPALP------SDWSEQNSAFFQQPSH 1171

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873
		PDZ_signaling	341..412	CDD:238492	20/71 (28%)
		CRS1_YhbY	<390..>436	CDD:294440	5/45 (11%)
		PDZ_signaling	462..548	CDD:238492	31/93 (33%)
		PDZ_signaling	<686..753	CDD:238492	22/140 (16%)
Grip1	XP_006514294.1	PDZ_signaling	110..190	CDD:238492	20/79 (25%)
		PDZ_signaling	209..292	CDD:238492	30/87 (34%)
		PDZ_signaling	307..390	CDD:238492	13/91 (14%)
		PDZ_signaling	526..614	CDD:238492	14/87 (16%)
		PDZ_signaling	627..711	CDD:238492	14/85 (16%)
		PDZ_signaling	727..808	CDD:238492	23/117 (20%)
		PDZ_signaling	1058..1138	CDD:238492	16/79 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900