DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment baz and Pard3b

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_006496361.1	Gene:	Pard3b / 72823	MGIID:	1919301	Length:	1238	Species:	Mus musculus

Alignment Length:	1658	Identity:	354/1658 - (21%)
Similarity:	567/1658 - (34%)	Gaps:	673/1658 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 PDSWVTVTHLQ-TQSGILDPDDCVRDVADDREQ-------------------------------- 93
            |..||.:.||: |..|||||||.:.||.:|:::
Mouse    42 PGYWVKIHHLEYTDGGILDPDDVLADVVEDKDKDAPYPTSLRKQVTSPLEEAVLQVSFLHSLAEA 106

  Fly    94 ---ILAHFDDPGPDPGVPQGGGDGASGSSSVGTGSPDIFR----------DPTNTEAPTCPRDLS 145
               ::|.||:..|.......||:.|...      |||.|.          .|...|....|..|.
Mouse   107 VLMLIAVFDEQEPLQKTESPGGNPADRQ------SPDAFETEVAAQLAAFKPVGGEIVVTPSALK 165

  Fly   146 TPHIEVTSTTSGPMAGLGVGLMVRRSSDPNLLASLKAEGSNKRWSAAAPHYAGGDSPERLFLDKA 210
                            ||..|:|||||||                |..||   .|:
Mouse   166 ----------------LGTPLLVRRSSDP----------------APGPH---ADA--------- 186

  Fly   211 GGQLSPQWEEDDDPSHQLKEQLLHQQQPHAANGGSSSGNH-QPFARSGRLSMQFLGDGNGYKWME 274
                                      ||..|   |.||.. :|..                  ::
Mouse   187 --------------------------QPSTA---SLSGQSLKPVV------------------LD 204

  Fly   275 AAEKLQNQPPAQQTYQQGSHHAGHGQNGAYSSKSLPRESKRKEPLGQAYESIREKDGEMLLIINE 339
            :.:.::|:            .|.:|:.....|...|     |:.|.....:: |..||
Mouse   205 STQNVENK------------EAMNGEQAGLLSLHRP-----KDELSDMTRAV-EISGE------- 244

  Fly   340 YGSPLGLTALP--DKEHGG--GLLVQHVEPGSRA-ERGRLRRDDRILEINGIKLIGLTESQVQEQ 399
             |.|||:..:|  ....|.  ||.::.:|..||. :.|..:.::.|::||.::|:..|.:|.|:.
Mouse   245 -GDPLGIHVVPFFSSLSGRILGLFIRGIEENSRCKQEGLFQENECIVKINNVELLDKTFAQAQDV 308

  Fly   400 LRRALESSELRVRVLRGDRNRRQQRDSKVA----------------------------------- 429
            .|:|::|..:.:.||. .:||.|...|.:.
Mouse   309 FRQAMKSPSVILHVLL-PQNREQYEKSVIGPLNIFGNNDGASRTKAAPPARGKPGLKAVHLTRAS 372

  Fly   430 --EMVEVATVSPTRKPHAAPVG--------TSLQVANTRKLGRKIEIMLKKGPNGLGFSVTTRDN 484
              |..|.|:...::.|....:|        :.|....::|..:||:|.|||||.||||:|.|||:
Mouse   373 SPEGEEPASPQQSKSPRVPRLGRKPSSPSLSPLMGFGSKKNAKKIKIDLKKGPEGLGFTVVTRDS 437

  Fly   485 PAGGHCPIYIKNILPRGAAIEDGRLKPGDRLLEVDGTPMTGKTQTDVVAILRGMPAGATVRIVVS 549
            ...|..||::|||||:|||::||||:.|||:|||:|..:||:||.::||:||....|.||.:|::
Mouse   438 SIHGPGPIFVKNILPKGAAVKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETVSLVIA 502

  Fly   550 RQQELAEQADQPAEKSAGVAVAPSVAPPAVPAAAAPAPPIPVQKSSSARSLFTHQQQSQLNESQH 614
            ||    |.:..|.|                         :..:....|.||
Mouse   503 RQ----EGSFLPRE-------------------------LKGEPDCYALSL-------------- 524

  Fly   615 FIDAGSESAASNDSLPPSSNSWHSREELTLHIPVHDTEKAGLGVSVKGKTCSNLNASGSSASSGS 679
                                  .|.|:|||.||::|:..||||||:||         ..|..:|:
Mouse   525 ----------------------ESSEQLTLEIPLNDSGSAGLGVSLKG---------NKSRETGT 558

  Fly   680 NGLMKHDGDLGIFVKNVIHGGAASRDGRLRMNDQLLSVNGVSLRGQNNAEAMETLRRAMVNTPGK 744
                    |||||:|::||||||.:||||||||||::|||.:|.|::|.||||||||:| :..|.
Mouse   559 --------DLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGETLLGKSNHEAMETLRRSM-SMEGN 614

  Fly   745 HPGTITLLVGRKILRSASSSDILDHSNSHSHSHSNSSGGSNSNGSGNNNNSSSNASDNSGATVIY 809
            ..|.|.|::.|:..|.....               |..|:.|.....|...:.:.|..:.::::|
Mouse   615 IRGMIQLVILRRPERPLEEL---------------SECGALSRPGFENCQEALSTSRRNDSSILY 664

  Fly   810 LSPEKREQRCNGGGGGGSAGNEMNRWSNPVLDRLTGGICSSNSAQPSSQQSHQQQPHPSQQQQQQ 874
                                                                   |..:...|.:
Mouse   665 -------------------------------------------------------PFGTYSPQDK 674

  Fly   875 RR---LPAAPVCSSAALRNESYYMATNDNWSPAQMHLMTAHGNTALLIEDDAEPMSPTLPARPHD 936
            |:   ||                   :|.|:                 |::..|..|..||
Mouse   675 RKDLLLP-------------------SDGWA-----------------ENEVPPSPPPHPA---- 699

  Fly   937 GQHCNTSSANPSQNLAVGNQGPPINTVPGTPSTSSNFDATYSSQLSLETNSGVEHFSRDALGRRS 1001
                                                          ||.  |:|.||
Mouse   700 ----------------------------------------------LEW--GLEDFS-------- 708

  Fly  1002 ISEKHHAALDARETGTYQRNKKLREERERERRIQLTKSAVYGGSIESLTARIASANAQFSGYKHA 1066
                |.:.:|:  ||.:.      ::....|.:...:                  ..:....|.:
Mouse   709 ----HSSGVDS--TGYFP------DQHVNFRTVTPVR------------------QPELINLKAS 743

  Fly  1067 KTASSIEQRETQQQLAAAEAEARDQLGDLGPSLGMKKSSSLESLQTMVQELQMSD----EPRGHQ 1127
            |:...:......|.||...:::..:  |.||:||:|||||||||||.|.|::.:|    .||.|.
Mouse   744 KSMDLVPDEGKVQSLADRRSDSPGK--DFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHM 806

  Fly  1128 ALRAPRGRGREDSLRAAVVSEPDASKPRKTWLLEDGDHEG-GFASQRNGPFQSSLNDGKHGCKSS 1191
            .    ||||..:|.|||:....|..        |:.|.:| ...|.|:|  .::||     |:|:
Mouse   807 V----RGRGCNESFRAAIDKSYDGP--------EEADADGLSDKSSRSG--HTALN-----CESA 852

  Fly  1192 RAKKPSILRGIGHMFRFGKNRKDGVVPVDNYAVNISPPTSVVSTATSPQLQQQQQQQLQQHQQ-Q 1255
            ....|.:               |.   |:|.|.||.............:|:.::::..::|:. :
Mouse   853 PQGNPEL---------------DN---VENKAKNIKKTKEKEKKKGKGKLKVKEKKLKEEHEDAE 899

  Fly  1256 QQIPTAALAALERNGKP------PAYQPPPPLPAPNGVGSNGIHQNDIFNHRYQHYANYEDLHQQ 1314
            :::......|:.|.||.      .|.|        .|...:|..:.:......:........||:
Mouse   900 RKMKRKGFGAMLRFGKKKDDKVGKAEQ--------KGAQKSGHPEEEELERMKEERERIGAKHQE 956

  Fly  1315 HQQHQISG-GDSTTSISETLSESTLECMRQQVIRQRIKVEAESRRHQHYHSQRSARSQDVSMHST 1378
            .::.|..| .|..|:::..:.:...:           :::....|..|:....::    .::..:
Mouse   957 LREKQARGLVDYATAVTGPVHDMDDD-----------EMDPNYARVNHFREPCAS----ANVFRS 1006

  Fly  1379 SSGSQPGSLAQPQ------------------------AQSNGVRPMS-----------SYYE--- 1405
            .|..:.|.||.|:                        |.::..|||:           .||:
Mouse  1007 PSPLRAGPLAYPRDGRPLSPDHLEGLYAKVNKPYHPPALADSGRPMAGTTDRIQKLRKEYYQARR 1071

  Fly  1406 -----YE-----------------------TVQQQRVGSIKHSHSSSATSSSSSPIN-------- 1434
                 ||                       :....|...::..::|.....|:.|::
Mouse  1072 EGFLLYEDENTRARPSDHDLRWVSGKGPDGSTHNLRFEGMERQYASLPRGGSADPVDYLTASPRG 1136

  Fly  1435 ------VPHWKAAAMNGYSPASLNSSARSRGPFVTQVTIR-EQSSGGIPAHLLQQHQ---QQQLQ 1489
                  :|::.     |..|......:..|.|.:....:| .|.....|||   ||:   :|.:.
Mouse  1137 RYNDRELPYYP-----GPHPVHAPRGSYPRPPDLRATDLRYPQYYPPPPAH---QHKGPFRQDVP 1193

  Fly  1490 QQQPTYQTV---QKMSGPSQYGSAAGSQPHASK 1519
            ...|.:|.|   |:|......||:....|:.::
Mouse  1194 PSPPQHQRVPVYQEMGRAGPRGSSPDQYPYRNQ 1226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873	39/157 (25%)
		PDZ_signaling	341..412	CDD:238492	22/75 (29%)
		CRS1_YhbY	<390..>436	CDD:294440	14/82 (17%)
		PDZ_signaling	462..548	CDD:238492	49/85 (58%)
		PDZ_signaling	<686..753	CDD:238492	41/66 (62%)
Pard3b	XP_006496361.1	DUF3534	2..74	CDD:338230	16/31 (52%)
		PDZ_signaling	236..323	CDD:238492	25/95 (26%)
		PDZ	415..504	CDD:214570	50/88 (57%)
		PDZ_signaling	536..624	CDD:238492	52/105 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850037
Domainoid	1	1.000	103	1.000	Domainoid score	I6774
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	327	1.000	Inparanoid score	I2449
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D387987at33208
OrthoFinder	1	1.000	-	-		FOG0002688
OrthoInspector	1	1.000	-	-		otm44252
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR16484
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2708
SonicParanoid	1	1.000	-	-		X2449
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.890