DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment baz and Dlg5

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_017171686.1	Gene:	Dlg5 / 71228	MGIID:	1918478	Length:	1931	Species:	Mus musculus

Alignment Length:	1602	Identity:	311/1602 - (19%)
Similarity:	521/1602 - (32%)	Gaps:	488/1602 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 DIFRDPTNTEAPTCPRDLSTPHIEVTSTTSGPMAGLGVG----LMVRRSSDPNLLASLKAEGSNK 187
            |.|:|.......|.|..|  |.:.:......|.:..|.|    ::....||....:||.:.|:
Mouse    66 DHFQDLRAALEKTQPHLL--PILYLNGVVGPPQSTEGAGSTYSVLSIMPSDSESSSSLSSVGT-- 126

  Fly   188 RWSAAAPHYAGGDSPERLFLDKAGGQLSPQWEEDDDPSHQLKEQL---------LHQQQPHAANG 243
              :..||      ||..|..:          ::.:|....|..||         |.::...|.:|
Mouse   127 --TGKAP------SPPPLLTE----------QQANDTVENLSIQLRLMTRERNELRKRLAFATHG 173

  Fly   244 GSSSGNHQPFARSG----RLSMQFLGDGNGYKWMEAAEKLQNQ---------PPAQQTYQQGSHH 295
              ::.:.:|:.|..    ||.:|.:      :.|...:.||||         ..|::|   ..:|
Mouse   174 --ATFDKRPYHRLNPDYERLKIQCV------RAMSDLQSLQNQHTNALKRCEEVAKET---DFYH 227

  Fly   296 AGHGQNGAYSSKSLPRESKRKEPLGQAYESIREKDGEMLLIINEYGSPLGLTALPDKEHGGGLLV 360
            ..|       |:.|..:::.|:.:    :.:|.::|::                   .....||.
Mouse   228 TLH-------SRLLSDQTQLKDDV----DMLRRENGKL-------------------RRERNLLQ 262

  Fly   361 QHVEPGSR------AERGRLR-RDDRILEINGI-----KLIGLTESQVQ------EQLRR----- 402
            |..|...|      .|.|.|| :..::|:.||.     ||......:::      :.||:
Mouse   263 QSWEDMKRLREEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLEVVKKDYDALRKRYSEK 327

  Fly   403 -ALESSELRVRVLRGDRNRR---------QQRDSKVAEMVEVATVSPTRKPHAAPVGTSLQVANT 457
             |:.:|:|......|:.|:|         ||||:.:....:.|.  ..|:........|...|..
Mouse   328 VAMHNSDLSRLEQLGEENQRLQKQTEMLTQQRDTAIQLQHQCAL--SLRRFETIHHELSKATAQN 390

  Fly   458 RKLGRKIEIMLKKGPNGLGFSVTTRDNPAGGHCPIYIKNILPRGAAIEDGRLKPGDR---LLEVD 519
            :.|..::|::..:........|.|.....        |....|.|...:.:|...:|   :.|:|
Mouse   391 KDLQWEMELLQSELTELRSKQVKTAKESE--------KYKEERDAVYSEYKLIMSERDQVISELD 447

  Fly   520 GTPMTGKTQTDV--------------------VAILR------GMPAG-ATVRIVVSRQQ----- 552
                  |.||:|                    :..||      .|.|| |...:.:.|:|
Mouse   448 ------KLQTEVELAESKLKSSTSEKKAASEEMEALRQIKDTVTMDAGRANKEVEILRKQCKALC 506

  Fly   553 ----ELAEQADQP--------AEKSAGVAVAPSV-------------APPAVPAAAAPAPPIPVQ 592
                |..::||..        .|:...||...|:             |...:..|.........|
Mouse   507 QELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQ 571

  Fly   593 KSSSARSL-------FTHQQQSQLNESQHF----IDAGSESAASNDSLPPSSNSWHSREELTLHI 646
            |:..:|.|       ...|.:.||.:...|    ..:..:||...||:     .|.: |.:....
Mouse   572 KNDVSRELKELNSCVHREQMECQLEKEARFRQLMAHSSHDSAIDTDSM-----EWET-EVVEFER 630

  Fly   647 PVHDTEKAGLGVSVKGKTCSNLNASGSSASSGSNGLMKHDGDLGIFVKNVIHGGAASRDGRLRMN 711
            ...|.:               |.|.|...:.|.|... ..||.||||..|..|..|  |||||:|
Mouse   631 ETEDID---------------LKALGFDMAEGVNEPC-FPGDCGIFVTKVDKGSIA--DGRLRVN 677

  Fly   712 DQLLSVNGVSLRGQNNAEAMETLRRAMVNTPGKHPGTITLLVGRKILRSASSSDILDHSNSHSHS 776
            |.||.:|.|.|..::..:|:    :|::|  |:  |.|.::|.|   |.:....::      :..
Mouse   678 DWLLRINDVDLINKDKKQAI----KALLN--GE--GAINMVVRR---RKSLGGKVV------TPL 725

  Fly   777 HSNSSG--GSNSNGSGNNNNSSSNASDNSGATVIYLSPEKREQRCNGGGGGGSAGNEMNRWSNPV 839
            |.|.||  ||....||.:..:...|     |.|:..||..:|       |..:.|:.:...:...
Mouse   726 HINLSGQKGSRPQDSGISLENGVYA-----AAVVPGSPAAKE-------GSLAVGDRIVAINGIA 778

  Fly   840 LDRLTGGICSS--NSAQPSSQQSHQQQPHPSQQQQQQRRLPAAPVCSSAALRNESYYMATNDNWS 902
            ||..:...|.|  .|.|.|...|               .|...|..||.:.:|....:..:|...
Mouse   779 LDNKSLNECESLLRSCQDSLTLS---------------LLKVFPQSSSWSGQNIFENIKDSDRML 828

  Fly   903 PAQMH--LMTAHGNTALLIEDDAEPMSPTLPARPHDGQHCNTSSANPS-QNLAVGNQGPPINTVP 964
            ..:.|  .:.||....||..:::.........|..|.:....|..:.| .:........|::. .
Mouse   829 SCRAHGPEVQAHNKRNLLQHNNSTQTDIFYTDRLEDRKELGHSGGSSSFLHKPFSGSSSPVSP-Q 892

  Fly   965 GTPSTSSNFDATYSSQLSLETNSGVEHFSRDALGRRSISEKHHAALDARET-----GTYQRNKKL 1024
            ..||||.....::.|..|.|...|:            :..:....|.:.||     |..:
Mouse   893 ACPSTSERSLNSFRSDTSAERGYGL------------VDMRSQRPLLSFETEVGPCGAVE----- 940

  Fly  1025 REERERERRIQLTK----SAVYGGSIESLTARIASANAQFSGYKHAKTASSI------EQRETQQ 1079
                     :.|.|    .:..||:.........|...:.|.||..|...||      ::.:|..
Mouse   941 ---------VPLDKIDPEGSNSGGTWPKAVLGSTSGPEKLSVYKKPKQRKSIFDPNTFKRPQTPP 996

  Fly  1080 QL--------AAAEAEARDQLGDLGPSLGMKKSSSL----------ESLQTMVQELQMSDEPRGH 1126
            ::        .....:...::|.|.|....::|.|:          ||..|:|.....:..|...
Mouse   997 KIDYLLPGPGLTHSPQPSKRVGSLTPPKPPRRSDSIKFQHRLETSSESEATLVGSSPSTSPPSAP 1061

  Fly  1127 QALRAPRGRGREDSLRAAVVSEP-DASKPRKTWLL------EDGDHEGGFASQRNGPFQSSLNDG 1184
            .....|              ||| .||.|||..:.      .:||.:..:...:. |....|...
Mouse  1062 PPSMDP--------------SEPTHASPPRKARVRIASSYHSEGDGDTSYLPAKK-PCDEDLTSQ 1111

  Fly  1185 KHGCKSSRAKKPSILRGIGHMFRFGKNRKDGVVPVDNYAVNISPPTSVVSTATSPQLQQQQQQQL 1249
            |......:.::|.                    ...::...|||   ||..|
Mouse  1112 KVDELGQKRRRPK--------------------SAPSFRPKISP---VVIPA------------- 1140

  Fly  1250 QQHQQQQQIPTAALAALE-------------RNGKPPAYQPPP-----PLPAPNGVGSNGIHQND 1296
            |..::|:.:|.....:.|             |:|.|..|...|     |.....|.....|.:|.
Mouse  1141 QCLEEQECVPAIGELSPEGQEWSPYSPGHASRHGNPLLYPNRPSVGTVPRSMTPGTTVGSILRNP 1205

  Fly  1297 IFNHRYQHYANYEDLHQQHQQHQISGGDSTTSISETLSESTLECMRQQVIRQRIKVEAESRRHQH 1361
            |:..|               .|::....|.....:..|:|....::.|   .|:.::...|....
Mouse  1206 IYTVR---------------SHRVLPCGSPPVPRDAGSQSLSPSVQHQ---GRLSLDLSHRACSD 1252

  Fly  1362 YHSQRSARSQDVSMHSTSSGSQPGSLAQPQAQSNGVR-PMSSYYEYETVQQQRVGSIKHSHSSSA 1425
            |...|:::..    :|..|.::.||.:..|.::..:: |::..|....:...| ||:.||..|
Mouse  1253 YSEMRASQGS----NSLPSSARLGSSSNLQFKAERIKIPLTPRYPRSVMGSDR-GSLSHSECS-- 1310

  Fly  1426 TSSSSSPINV--------PHWKAAAMN--GYSPASLNSSARSRGPFVTQVTIREQSSGGIPAHLL 1480
             :...||:|:        |...|:.:.  ..:|:|.....:.| |||
Mouse  1311 -TPPRSPLNIDTLSSCSQPQTTASTLPRIAVNPSSHGERRKDR-PFV------------------ 1355

  Fly  1481 QQHQQQQLQQQQPTYQTVQKMSGPSQYGSAAGSQ--PHASKV 1520
                      ::|.:..|||.|.|......:|.:  .:.|||
Mouse  1356 ----------EEPRHVKVQKGSEPLGISIVSGEKGGVYVSKV 1387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873	11/50 (22%)
		PDZ_signaling	341..412	CDD:238492	19/94 (20%)
		CRS1_YhbY	<390..>436	CDD:294440	12/66 (18%)
		PDZ_signaling	462..548	CDD:238492	20/115 (17%)
		PDZ_signaling	<686..753	CDD:238492	27/66 (41%)
Dlg5	XP_017171686.1	Takusan	129..213	CDD:368141	22/107 (21%)
		Smc	<141..564	CDD:224117	88/479 (18%)
		PDZ_signaling	625..712	CDD:238492	33/112 (29%)
		PDZ_signaling	<741..800	CDD:238492	16/70 (23%)
		PDZ	1357..1439	CDD:214570	10/31 (32%)
		dbPDZ_assoc	1437..1512	CDD:374667
		PDZ	1513..1594	CDD:214570
		SH3_DLG5	1610..1672	CDD:212794
		GuKc	1744..1920	CDD:214504
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900