DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment baz and Pdzph1

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	NP_081277.1	Gene:	Pdzph1 / 69239	MGIID:	1916489	Length:	1238	Species:	Mus musculus

Alignment Length:	1460	Identity:	265/1460 - (18%)
Similarity:	455/1460 - (31%)	Gaps:	484/1460 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 TNTEAPTCPRDLSTPHIEVTSTTSGPM----AGLGVGLMVRRSSDPNLLASLKAEGSNKRWSAAA 193
            :.|....||:::.....::...||..:    ..||   .::.:.|.|:.||:..: .|..:....
Mouse     9 SQTSGQVCPQNVKDLEEDIKGHTSETVFHQTRTLG---KLKENGDENITASINGK-QNSSFLVKN 69

  Fly   194 PHYAGGDSP-----ERLFLDKAGGQLSPQWEE------DDDPSHQLKEQLLHQQQPHAANG-GSS 246
            ...|..||.     |..:...|   :|||.||      .:|....|..::..:..|:.... ..:
Mouse    70 EKQAPSDSTIHKSMENGYTPPA---ISPQLEEVLPVAMFNDREKSLPGKITTEDFPNTVEVLKPA 131

  Fly   247 SGNHQPFARSGRLSMQ-------FLGDGNGYKWMEAAEKLQNQ--PPAQQTYQ-----QGSHHAG 297
            .|......:.|..::.       |...|        |:.|..:  |...|.|.     :||...|
Mouse   132 KGKFIREVKCGAFNVHVETTKSIFCKTG--------AQNLTKRRCPTCHQHYSVQQVWRGSKSRG 188

  Fly   298 HGQNGAYSSKS--LPRESKRKEPLGQAYESIREKDGEMLLIINEYGSPLGLTALPDKEHGGGLLV 360
            |     :|...  |..|.||:.|  ..|.....:.....:.|:..|..:.:..:..|::   ..:
Mouse   189 H-----FSKHRTVLAEEFKRRVP--STYRRGVSRSEVPSVNISIVGKEIMVEYISKKQN---TFI 243

  Fly   361 QHVEPGSRAERGRLRRDDRILEINGIKLIGLTESQVQEQLRRALESSELRVRVLRGDRNRRQQRD 425
            ....|.|..:..:.||             |..:....|....|.:..      :....|:|.:..
Mouse   244 NICHPNSIGKLTKHRR-------------GPLKHTTDEPCESASQPG------INHPENQRLENQ 289

  Fly   426 SKVAEMVEVA--TVSPTRKPHAAPVGTSLQVANTRKLGRKIEIMLKKGPNGL---------GFSV 479
            .:.::....|  :|:..:|.::..:..||.....|:         |:.||.|         |.|.
Mouse   290 HQSSDAFHDAPCSVNAVQKENSDTIVVSLSSPPRRE---------KEKPNTLPSAPDDSEEGESA 345

  Fly   480 T--------TRDNPAGGHCPIYIKNILPRGA----------------AIEDGR------------ 508
            |        |:|.|...|| ....:.||..:                ::||.|
Mouse   346 TSPQKVLQITQDKPLEQHC-FTADSCLPTSSETLRTTSLNNVDLSKMSLEDSRDVDEERKNSSDV 409

  Fly   509 ---LKPGDRLLEVDGTPMTGKTQTDVVAILRGMP----AGA--------TVRIVVSRQQELAEQA 558
               :.|..::     .|.|..|...:.|:...:|    :|:        |::::.::...:..:.
Mouse   410 RENITPDSQV-----QPCTAGTNGPLSAVNSIIPIQDASGSEFSPLSFLTLQLLGAKADNMGCRG 469

  Fly   559 DQ--PAEKSAGVAVAPSVAPPAVPAAAAPAPPI-----------PVQKSSSARSLFTHQQQSQLN 610
            ::  |.|   |...:.|:..|....||.|:|.:           ||:.:.:..|...:....:..
Mouse   470 EETLPGE---GHESSNSLLFPVSEQAAKPSPLLSPSHRVSRCSEPVETTGNTFSFSQYIGVEREQ 531

  Fly   611 ESQHF--IDAGSESAASNDSLPP------------------------------SSNSWHSREELT 643
            |..|:  |:..|....|:.::.|                              ||..|:..|:..
Mouse   532 EKVHYRLINKASLHNDSSSNIQPLERKDPQSPAVTIASCSILVPKSPLHGNIHSSVEWNQTEDHA 596

  Fly   644 LHIPVHDTEKAGLG---VSVKGKTCSNL-------NASGSSASSGSNGLMKHDGDLGIFVKNVIH 698
            .|     .|:|||.   |.|.....:.|       |...|:..|.|...:::..:...:::||
Mouse   597 NH-----AERAGLSRMEVPVMASITNELEQSLATQNYKESTVDSNSPMAIRNPRESTSYLENV-- 654

  Fly   699 GGAASRDGRLRMNDQLLSVNGVSLRGQNNAE---AMETLRRAMVNTPGKHPGTITLLVGRKILRS 760
            |..||:  .|.:...:...|...|..:|..|   .|:.|:.:..:|...|......|:.:.:
Mouse   655 GDDASQ--ALPVVKNMCHRNFEDLTRENQNEICSQMDFLQNSSESTSVGHTTEKLFLIDKTL--- 714

  Fly   761 ASSSDILDHSNSHSHSHSNSSGGSNSNGSGNNNNSSSNASDNSGATVIYLSPEKREQRCNGGGGG 825
              :||  |.||| :..|..         .|.||.....|......:.:|         |...|
Mouse   715 --ASD--DDSNS-NRDHKT---------CGLNNFQQEPAECQRTTSRVY---------CEESG-- 754

  Fly   826 GSAGNEMNRWSNPVLDRLTGGICSSNSAQPSSQQSHQQQPHPSQQQQQQRRLPAAPVCSSAALRN 890
                                     |...|:....|......|.|:|:             ||::
Mouse   755 -------------------------NQRYPTEVSCHPVDILLSPQKQK-------------ALKD 781

  Fly   891 ESYYMATNDNWSPAQMHLMTAHGNTALLIEDDAEPMSPTLPARPHDGQHCNTSSANPSQNLAVGN 955
            ::..:   :|.......|....|..:...:::|.........:..||:.|:::
Mouse   782 QNLEI---NNPRKLSQELALRGGRASDGSQEEAIEQWARRRQQFKDGKRCSSA------------ 831

  Fly   956 QGPPINTVPGTPSTSSNFDATYSSQLSLETNSGVEHFSRDALGRRSISEKHHAALDARETGTYQR 1020
                     |..|..|||  |..|..|.:.:| |:...|               :|..|.|.|..
Mouse   832 ---------GGSSVISNF--TEGSITSDDVHS-VDFGFR---------------VDIEEKGFYTE 869

  Fly  1021 N-----------------------KKLREERERERRIQLTKSA---VYGGSIESLTARIASANAQ 1059
            |                       ||.|....|||.::|.|..   .:|..|            |
Mouse   870 NFHSTAWVFRGDDGNPEDSPRCLSKKPRPVAVRERTVRLFKGTGDYPWGFRI------------Q 922

  Fly  1060 FSGYKHAKTASSIEQRETQQQLAAAEAEARDQLGDLGPSLGMKKSSSLESLQTMVQELQMSDEPR 1124
            ||        ..|...|.....||.||..  |:||:..|:...:.:|:|..:.:
Mouse   923 FS--------KPIVVTEVDTNSAAEEAGL--QIGDVVLSVNGTEVTSVEHAEAV----------- 966

  Fly  1125 GHQALRAPRGRGREDSLRAAVVSE----PDASKPRKTWLLEDGDHEGGFASQRNGPFQSSLNDGK 1185
             |.|.:.      .|.|...|.|:    |:...|.....|....|.|.....|
Mouse   967 -HLAKKG------LDILTMVVASDISRCPNTPWPTCRGYLHKRTHSGFVKGWR------------ 1012

  Fly  1186 HGCKSSRAKKPSILRGIGHMFRFGKNRKD--------------GVVPVDN-----YAVNISPPTS 1231
                    |:..:|:..|.:..: |:|||              ..|.:||     :..|..|.:.
Mouse  1013 --------KRWFVLKHDGFLLYY-KHRKDEGKWPPLDMIKLEGAEVDIDNSLGKPFVFNCMPQSG 1068

  Fly  1232 ---VVSTATSPQ-----LQQQQQQQLQQHQ----QQQQIPTAALAALERNGKPPAYQPPPPLPAP 1284
               :...|||.|     |:..|:.....||    :...:..::|             ||..:..|
Mouse  1069 SRILCLCATSNQEMKRWLEAMQRAARPVHQNHVWEDVTVHNSSL-------------PPLAIKHP 1120

  Fly  1285 NGVGSNGIHQ----NDIFNHRYQHYANYED----LHQQHQQHQISGGDSTTSISETLSESTLECM 1341
            ..:|.  :||    .|::   .|||...:|    .:...:..|.|||......|  :||.| ...
Mouse  1121 ECLGL--LHQLERSTDVW---IQHYCILKDGCLYFYASIRSTQASGGLYLQGYS--VSEQT-HGF 1177

  Fly  1342 RQQVIRQRIKVEAESRRHQHYHSQRSARSQ 1371
            .|.||  .:|..:|..:..::.::....:|
Mouse  1178 EQPVI--ELKPSSEEFKTFYFCAENKTENQ 1205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873	7/44 (16%)
		PDZ_signaling	341..412	CDD:238492	9/70 (13%)
		CRS1_YhbY	<390..>436	CDD:294440	6/47 (13%)
		PDZ_signaling	462..548	CDD:238492	25/145 (17%)
		PDZ_signaling	<686..753	CDD:238492	14/69 (20%)
Pdzph1	NP_081277.1	PDZ_signaling	903..981	CDD:238492	25/117 (21%)
		PH-like	986..1093	CDD:302622	24/127 (19%)
		PH	993..1094	CDD:278594	23/121 (19%)
		PH-like	1123..1215	CDD:302622	22/93 (24%)
		PH	1125..1216	CDD:278594	21/91 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900