DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment baz and Pdzd2

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	NP_001074533.1	Gene:	Pdzd2 / 68070	MGIID:	1922394	Length:	2796	Species:	Mus musculus

Alignment Length:	1713	Identity:	337/1713 - (19%)
Similarity:	544/1713 - (31%)	Gaps:	544/1713 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 DPGPDPGVPQGGGDGASGSSSVGTG---SPDIFRDPTNTEAPTCPRDLSTPHIEVTSTTSGPMAG 161
            :||..|.:..|......|..:...|   .|.|.:.|.::::.:.......|..|:.:.|.   :.
Mouse   196 EPGETPTLELGDQTSKKGKRTRKFGVISRPAIIKAPEDSKSNSGCDTADDPSSELENGTD---SE 257

  Fly   162 LGVGLMVRRSSDPNLLASLKAEGSNKRWSAAAPHYAGGDSPERLFLDKAGGQLSPQWEEDDDPSH 226
            ||.|......:.||   |||        ..|.||.      ||...|:......|:.|.   |.
Mouse   258 LGNGHAFELENGPN---SLK--------DVAGPHL------ERSEADREAELRVPKTEA---PL- 301

  Fly   227 QLKEQLLHQQQPHAANGGSSSGNHQPFARSGRLSMQFLGDGNGYKWMEAAEKLQNQPPAQQTYQQ 291
                              |.|.:.:.|:::|:.:.|
Mouse   302 ------------------SDSNDKRRFSKTGKTNFQ----------------------------- 319

  Fly   292 GSHHAGHGQNGAYSSKSLPRESKRKEPLGQAY--ESIREKDGEMLLIINEYGSPLGLTALPDKEH 354
                         ||.||.||.     :|:.:  |.::|.||..:.:....||         |..
Mouse   320 -------------SSDSLAREE-----VGRIWKMELLKESDGLGIQVSGGRGS---------KRS 357

  Fly   355 GGGLLVQHVEPGSRAER-GRLRRDDRILEINGIKLIGL--------------------------- 391
            ...::|..|:.|..|.| |||...|.:|.|||..|:||
Mouse   358 PHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKESSA 422

  Fly   392 ------------------------TESQVQEQLRRALE---SSELRVRVLRGDRNR--------- 420
                                    |:::.||..|...|   |:.:|..:|..:.::
Mouse   423 EDLLKLTSKSLPDLTSSVEDISSWTDNEDQEAARDDEEGTGSAAVRGTMLGSEESQDVGSSEESK 487

  Fly   421 ------RQQRDSKV------------AEMVE---------------VATVSPTRKPHAAP----- 447
                  .:|.:||:            .|.||               :..||...:.|:.|
Mouse   488 GNNLESPKQGNSKMKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDS 552

  Fly   448 VGTSLQVANTRKLGRKIEI-------------------MLKKGPNGLGFSVTTRDNPAGGHCPIY 493
            .|||.:....:|..|.:..                   :.|:...|||||:....:...|...|:
Mouse   553 TGTSQEYHIVKKSTRSLSTTHVESPWRLIRPSVISIIGLYKEKGKGLGFSIAGGRDCVRGQMGIF 617

  Fly   494 IKNILPRGAAIEDGRLKPGDRLLEVDGTPMTGKTQTDVVAILRGMPAGATVRIVVSRQQELAEQA 558
            :|.|.|.|:|.||||||.||.:|:|:|.|:.|.|..:.:...:.:.:|..|..|.::
Mouse   618 VKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTK-------- 674

  Fly   559 DQPAEKSAGVAVAPSVAPPAVPAAAAPAPPIPVQKSSSARSLFTHQQQSQLNESQHFIDAGSESA 623
                      .::||:.|.:.|                     ||..:|   .|..|..:|...|
Mouse   675 ----------LLSPSLTPCSTP---------------------THMSRS---SSPSFNSSGGAPA 705

  Fly   624 ASNDSLPPSSNSWHS----REELTLHIPVHDTEKAGLGVSVKGKTCSNLNASGSSASSGSNGLMK 684
            ........|::....    ::.:.:.:.::...:.|||:   |..|..|..|..
Mouse   706 GGGQDEGGSASLGRKAPGPKDRIVMEVTLNKEPRVGLGI---GACCLALENSPP----------- 756

  Fly   685 HDGDLGIFVKNVIHGGAASRDGRLRMNDQLLSVNGVSLRGQNNAEAMETLRRAMVNTPGKHPGTI 749
                 ||::.::..|..|..:..|...||:|.||.|::|    ..|:..:...:...|   ||.:
Mouse   757 -----GIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVR----HAALSKVHAILSKCP---PGPV 809

  Fly   750 TLLVGRKILRSASS---SDILDHSNSHSHSHSNSSGG------SNSNGSGNNNNSSSNAS----- 800
            .|::||......|.   .:::..|.......:|||..      |.|....::..|.|..|
Mouse   810 RLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPSLGTPLKSPSLAKKDSLLSESELSQYFVH 874

  Fly   801 DNSGATVIYLSPEKREQRCNGGGGGGSAGNEMNRWSNPVLDRLTGGICSSNSAQPSSQQSHQQQP 865
            |..|:...::.....::  :..|.|.....:.:..:.|...|.||. ..:||......|......
Mouse   875 DGQGSLSDFVVAGSEDE--DHPGSGYETSEDGSLLTVPSAYRETGK-ARANSLVTLGSQRGSGLL 936

  Fly   866 HPSQQQQQQRRLPAAPVCSSAALRNESYYMATNDNWSPAQMHLMTAHGNTALLIED-DAEPMSPT 929
            |......:|..||.:|    ..|||...          .|..:.....|.....|| |.|....:
Mouse   937 HKQVTVARQASLPGSP----QVLRNPLL----------RQRRVRCYDSNDGSDDEDFDGEGDCVS 987

  Fly   930 L------PARPHDGQHCNTSSANPSQNLAVGNQG-----PPINTVPGTPSTSSNFDATYS----- 978
            |      |.||........:.|..|:::.|..|.     |.::.....|...|:.|:.:|
Mouse   988 LPGVLPGPGRPLVQDDTRFALATSSKSIDVNKQDERLQKPLVSKACSVPLLGSSLDSEHSIHGGT 1052

  Fly   979 -------SQL--SLETNSGVEHFSR--DALGRRSISE-KHHAALDAR-----ETGTY--QRNKKL 1024
                   :.|  |:||.......||  :..|.||..: ::....|.:     |.||.  |:.:.|
Mouse  1053 AGTPPKAASLPGSVETPKNGPGGSRRKEMSGSRSSPKLEYRVPADTQSPRSPENGTSPPQKTENL 1117

  Fly  1025 REERERERRI----------QLTKSAVYGGSIESLTARIASANAQFSGYKHAKTA---------- 1069
            ....:...||          :.......|...:.|..:.:|.....:|::...||
Mouse  1118 VSRHKPVARISPHYKRSDAEEAPSETANGPCAQDLKVQASSVKDPVAGHQPGGTAEKELRGNPTP 1182

  Fly  1070 --SSIEQR---------------ETQQQLAAAEAEAR-----DQLGDLGPSLGMKKSSSLESLQT 1112
              ||:...               ....|.||.|....     |...|..||.|..:....:|.:|
Mouse  1183 GDSSVPTNCGPASTPCHPNTGLPTENPQGAAPECGPHPGTGWDGSSDHPPSPGKSREVRPDSSET 1247

  Fly  1113 MV---QELQM----------SDEPRGHQALRAPRGRGREDSLRAAVVSEPDASKPRKTWLLEDGD 1164
            ..   |.||.          :.||......:......|..|.|....:.||:|   :|| ...||
Mouse  1248 PAVTEQVLQPESLSQPVSPGTSEPESQGVSKMKPASQRSLSPREKASALPDSS---RTW-AGPGD 1308

  Fly  1165 -----------------------HEGGFASQR----NGPFQSSLNDGKHGCKSSRAKKPSILR-- 1200
                                   |......:|    :||.::....|.  |..:..|..::|.
Mouse  1309 STPSTRRAAVPMSIGETRATAIPHPSLLGQERSRDPSGPSKALETPGH--CVPTSLKDRALLEET 1371

  Fly  1201 --GIGHMFRFGKNRKDGVVPVDNYAV----NISPPTSV---VSTATSPQLQQQ-QQQQLQQHQQ- 1254
              ..|.:...|.:     |||.....    ..||.|.:   :..|....|.|. |:...:.||.
Mouse  1372 ASASGKLSHAGPS-----VPVTTDGTLSGSTESPVTDIDKFIGEAPEAWLSQSPQRADCRTHQDI 1431

  Fly  1255 -QQQIPTAALAALERNGKPPAYQPPPPLP----APNGVGSNGIHQ------NDIFNHRYQHYANY 1308
             :.|.|..|......:||......||| |    .|:.:.|  :|.      |..|.:.|..  |:
Mouse  1432 FESQPPGGAGGGSSHHGKTGGTGSPPP-PQWTFQPSVLDS--VHPDKQLAGNKNFLNNYSR--NF 1491

  Fly  1309 EDLHQQHQQHQISG---GDSTTSISETLSESTLECMRQQVIRQRIKVEAESRR-------HQHYH 1363
            ...|:.........   ||:..|.|:  .||.:|..|           |.:|.       |:...
Mouse  1492 SSFHEDGVSEPSPSSMYGDAEDSSSD--PESLVEDPR-----------AAARNNWPAPPSHESSR 1543

  Fly  1364 SQRSARSQDVSMHSTSSGSQPGS--LAQPQAQ-SNGVRPMSSYYEYETVQQ---QRVGS------ 1416
            .:.|:.|:|..:...:.|..|.:  .||..|| :.|..|        :|||   :.||.
Mouse  1544 KEGSSESEDEQIEICAPGGCPETPVPAQAPAQAAGGAVP--------SVQQTVREPVGDACEKAC 1600

  Fly  1417 IKHSHSSSATSSSSSPINVPHWKAAAMNGYSPASLNSSARSRGPFVTQVTIREQSSGGIPAHLLQ 1481
            .....|::....||.|.:  ....:::...:.|.:.:| ||..|...:.|:...|:|.:
Mouse  1601 FMTGASNTCIPGSSQPFS--FLDVSSLEHETWAGVQTS-RSHMPGCAEETLAVSSTGSV------ 1656

  Fly  1482 QHQQQQLQQQQPTYQTVQKMSGP 1504
                  :...||: ||.:....|
Mouse  1657 ------VGDSQPS-QTTRPCGNP 1672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873	15/76 (20%)
		PDZ_signaling	341..412	CDD:238492	26/125 (21%)
		CRS1_YhbY	<390..>436	CDD:294440	16/141 (11%)
		PDZ_signaling	462..548	CDD:238492	30/104 (29%)
		PDZ_signaling	<686..753	CDD:238492	17/66 (26%)
Pdzd2	NP_001074533.1	PDZ_signaling	335..416	CDD:238492	23/89 (26%)
		PDZ_signaling	591..672	CDD:238492	29/80 (36%)
		PDZ_signaling	729..813	CDD:238492	24/109 (22%)
		PHA03307	1050..>1355	CDD:223039	55/308 (18%)
		PHA03247	<1197..1562	CDD:223021	79/393 (20%)
		PDZ_signaling	2581..2663	CDD:238492
		PDZ	2709..2791	CDD:214570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810