DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment baz and Pdzd2

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_038959013.1	Gene:	Pdzd2 / 65034	RGDID:	619958	Length:	2818	Species:	Rattus norvegicus

Alignment Length:	1632	Identity:	321/1632 - (19%)
Similarity:	525/1632 - (32%)	Gaps:	461/1632 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 LMVRRSSDPNLLASLKAEGSNKRWSAAAPHYAGGDSPERLFLDKAGGQLS-----PQWEEDDD-- 223
            |.:...|.|:|.:|::...|   |:......|.|:..|      ..|..:     |..||..|
  Rat   426 LKLTSKSLPDLTSSVEDMSS---WTDNEDQEAAGEDEE------GSGPAAVRVTMPGSEESQDVG 481

  Fly   224 PSHQLKEQLLHQQQPHAANGGSSSGNHQPFARSGRLSMQFLGDGNGYKWMEAAEK-----LQNQP 283
            .|.:.|..|...:|          ||.:...:| |||       .|...:|:.|:     ::|..
  Rat   482 SSEESKGNLESPKQ----------GNCKTKLKS-RLS-------GGVHRLESVEEYNELMVRNGD 528

  Fly   284 P---AQQTYQQGSHHA------GHGQNGAYSSKSLPRESKRKEPLGQAYESIREKDGEMLLIINE 339
            |   ..:..:.|..|:      ..|.:..|........|.....:...:..||.....::.:..|
  Rat   529 PRIRMLEVSRDGRKHSLPQLLDSTGTSQEYHIVKKSTRSLSTTHVESPWRLIRPSVISIIGLYKE 593

  Fly   340 YGSPLGLTALPDKEHGG--------GLLVQHVEP-GSRAERGRLRRDDRILEINGIKLIGLTESQ 395
            .|..||.:..     ||        |:.|:.:.| ||.||.|||:..|.||::|||.:.|||..:
  Rat   594 KGKGLGFSIA-----GGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQE 653

  Fly   396 ---VQEQLRRALESSELRVRVLRGDRNRRQQRDSKVAEMVEVATVSPTRKPHAAPVGTSLQVANT 457
               ..:|:|..|....:|.::|    :......|....|...::.|........|.|...:...:
  Rat   654 AIHTFKQIRSGLFVLTVRTKLL----SPSLTPCSTPTHMSRSSSPSFNTNSGGTPAGGGQEEGGS 714

  Fly   458 RKLGRK---------IEIMLKKGPN-GLGFS---VTTRDNPAGGHCPIYIKNILPRGAAIEDGRL 509
            ..||||         :|:.|.|.|. |||..   :...::|.|    |||.::.|...|..:..|
  Rat   715 SSLGRKAPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPG----IYIHSLAPGSVAKMESNL 775

  Fly   510 KPGDRLLEVDGTPMTGKTQTDVVAILRGMPAGATVRIVVSR-------QQELAEQADQPAEKSAG 567
            ..||::|||:...:.....:.|.|||...|.| .||:|:.|       :||:.|
  Rat   776 SRGDQILEVNSVNVRHAALSKVHAILSKCPPG-PVRLVIGRHPNPKVSEQEMDE----------- 828

  Fly   568 VAVAPSVAPPAVPAAAAPAPPIPVQKSSSARSLFTHQQQSQLNE---SQHFIDAGSES------A 623
             .:|.|....:..|.::|....|::..|.|:      :.|.|:|   ||:|:..|..|      |
  Rat   829 -VIARSTYQESREANSSPGLGTPLKSPSLAK------KDSLLSESELSQYFVHDGQGSLSDFVVA 886

  Fly   624 ASNDSLPPSSNSWHSREELTLHIPVHDTEKAGLGVSVKGKTCSNLNASGSSASSGSNGLMKHDGD 688
            .|.|...|.| .:.:.|:.:| :||....||         ..::|...||..:|
  Rat   887 GSEDEDHPGS-GYETSEDGSL-LPVPSAHKA---------RANSLVTLGSQRTS----------- 929

  Fly   689 LGIFVKNVIHGGAASRDGRLR-MNDQLLSVNGVSLRGQNNAEAMETL--RRAMVNTPGKHPGTIT 750
             |:..|.|.....||..|..: :.:.||....|.....|.....|..  ....::.||..||...
  Rat   930 -GLLHKQVTVARQASLPGSPQVLRNPLLRQRRVRCYDSNGGSDDEDFDGEGDCISLPGVLPGPGK 993

  Fly   751 LLV------------------------GRKILRSASSSDILDHSNSHSHSHSNSSGG-------- 783
            .||                        .:.::..|.|..:|..|....||..|.:||
  Rat   994 PLVEDDTRPALTTSSKSIDVNKQEERLQKPLVSKACSVPLLGSSLDSEHSILNGTGGTPPKVASL 1058

  Fly   784 --------SNSNGSGNNNNSSSNAS-----------------DNSGA-------------TVIYL 810
                    :...|||....|.|.:|                 :|..:             .|..:
  Rat  1059 PGSGETPKNGPRGSGRKEMSGSRSSPKLEYRVPTDTQSPRSPENHTSPPQKSENLVSRHKPVARI 1123

  Fly   811 SPE-KRE--QRCNGGGGGGSAGNEMNRWSNPVLDRLTGGICSSNSAQP--SSQQSHQQQPHPSQQ 870
            ||. ||.  :...||...|....::...::||.|.:||       .||  ::::..|..|.|...
  Rat  1124 SPHYKRSDAEEAPGGTANGPCAQDLKVQASPVKDPVTG-------RQPGGTAEKELQGNPTPGDS 1181

  Fly   871 QQQQRRLPAAPVCSSAALRNESYYMATNDNWSPAQMHLMTAHGNTALLIEDDAEPMSPTLPARPH 935
            .......||:..|                            |.||.|..|:   |........||
  Rat  1182 SVPTNCGPASTPC----------------------------HPNTGLPTEN---PQGAAPECVPH 1215

  Fly   936 DGQHCNTSS---ANPSQNLAVGNQGPPINTVPGTPSTSSNFDATYSSQLSLETNSGVEHFSRDAL 997
            .|...:.||   .:|.::..|........||........:.....|.:.|...:.|:......:
  Rat  1216 PGTGWDGSSEHLCSPGKSREVHPDSSETPTVAEQVHQPESLSQPVSPRTSEPESQGISKMKPPS- 1279

  Fly   998 GRRSISEKHHAALDARETGTYQRNKKLREERERERRIQLTKS-------AVYGGSIESL-TARIA 1054
             :|.:|.:..|:.....:..:...   .:.....|||.:..|       |:...|:.|. .:|..
  Rat  1280 -QRCVSPREKASTPPDSSRAWAAP---GDSSPSTRRIAVPMSTGAAPATAIPQASLVSQERSRGL 1340

  Fly  1055 SANAQFSGYKHAKTASSIEQRETQQQLAAAEAEARDQLGDLGP-----SLGMKKSSSLESLQTMV 1114
            |..::..|.|......|::.....:..|.|..:........||     :|.....:.:..:...:
  Rat  1341 SGPSKGLGTKELCIPKSLKDGALLEDTAPASGKMSHASSPSGPVATERTLSGSPENPVTDIDNFI 1405

  Fly  1115 Q---ELQMSDEP-----RGHQ---ALRAPRGRGREDSLRAAVVSEPDASKPRKT----------W 1158
            :   |.::|..|     |.|.   ..:.|.|.|...|..|.:|.....|.||||          |
  Rat  1406 EEASEARLSQSPQKADCRAHGDTFESQPPGGAGSSSSHHAQMVRSDQTSSPRKTGGTGSPPPQQW 1470

  Fly  1159 LLE----DGDH-------EGGFASQRNGPFQSSLND--GKHGCKSSRAKKPSILRGIGHMFRFGK 1210
            .|:    |..|       ...|.:..:..|.:...|  ...|...|....||.:.|
  Rat  1471 ALQPSVLDSIHPDKHLAVNKTFLNNYSRNFSNFHEDSISLSGPGGSSEPSPSSMYG--------- 1526

  Fly  1211 NRKDGVVPVDNYAV--------NISPPTSVVSTATSPQLQQQQQQQLQQHQQQQQIPTAALAALE 1267
            |.:|.....::.|.        |.|||.|..|:......:.:.::               :....
  Rat  1527 NAEDSSSDPESLAEDPGAAARNNWSPPLSPESSPKEGSSESEDER---------------IEICS 1576

  Fly  1268 RNGKP--PAYQPPPP-------LPAPN------------------GVGSNGIHQN-------DIF 1298
            .:|.|  |...|||.       ||...                  |.....|..:       |:.
  Rat  1577 TDGCPGTPVTAPPPTQVALCPVLPVQQRAVCKPVGDICERACFVPGASRTSIPDSSQPFSFLDVS 1641

  Fly  1299 NHRYQHYANYEDLHQQHQQHQISGGDSTTSISETLSES-----TLECMR---------------- 1342
            :...:.:|:. :..|.|......|....||.|..:.:|     |..|..
  Rat  1642 SEEPETWASI-NASQNHMPVCTEGIMDVTSTSSNMGDSQSSQMTRHCRNAPFVLGNPDMVNDLGR 1705

  Fly  1343 --------------QQVIRQRIKVEAESRRHQHYHSQRSARSQDVSMHSTSSGSQPGSLAQPQAQ 1393
                          ..|:|....:.||        ..::..:....:|....|:....|.:|:..
  Rat  1706 DLLDEGAPKEGAAAASVMRSVFALGAE--------GPKNGEAVLADLHIAERGNLEDLLQKPKTI 1762

  Fly  1394 SNGVRPMSSYYEYETVQQQRVGSIKHSHSSSATSSSS----------SPINVPHWKAAAMNGYSP 1448
            |.  ||:.::  ::.:.:...||  |..|:|....||          :.:|..|.|...: ..||
  Rat  1763 SR--RPILTW--FKEINKDSQGS--HLRSTSEKEQSSMLALGPGSKANMVNTGHRKGVTV-PKSP 1820

  Fly  1449 ASLNSSARSR-------------------GPFVTQVTIREQSSGGIPAHLLQQHQQQQLQQQQPT 1494
            .|...|..::                   .|.:.::..:.::|..:|..:..:..:...::..|:
  Rat  1821 PSRQKSQENKDLPPKSPVETLGNCQKPKCSPKLKRLNSKGKASPEVPVAISTKGSRNDHRKTLPS 1885

  Fly  1495 YQTVQKM 1501
            .|...||
  Rat  1886 PQASHKM 1892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873	2/7 (29%)
		PDZ_signaling	341..412	CDD:238492	28/82 (34%)
		CRS1_YhbY	<390..>436	CDD:294440	10/48 (21%)
		PDZ_signaling	462..548	CDD:238492	30/98 (31%)
		PDZ_signaling	<686..753	CDD:238492	15/69 (22%)
Pdzd2	XP_038959013.1	PDZ_signaling	335..416	CDD:238492
		PDZ_signaling	590..671	CDD:238492	28/85 (33%)
		PDZ_signaling	729..813	CDD:238492	28/88 (32%)
		PHA03247	<985..1446	CDD:223021	90/503 (18%)
		PDZ_signaling	2603..2677	CDD:238492
		PDZ_signaling	2731..2813	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810