DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment baz and lnx2b

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	NP_998105.2	Gene:	lnx2b / 564464	ZFINID:	ZDB-GENE-040426-2500	Length:	678	Species:	Danio rerio

Alignment Length:	661	Identity:	147/661 - (22%)
Similarity:	226/661 - (34%)	Gaps:	212/661 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 STTSGPMAG------LGVGLMVRRSSDPNLLASLKAEGSNK---RWS----AAAPHYAGGDSPER 204
            |.:.|.:|.      :|....:...|:|.|:.....||.:.   |.|    |........|..|.
Zfish   157 SKSDGDLADAKSAQTIGRTAQLSAPSEPGLVNPAFEEGEDDTPLRCSLVAEATVVELFREDPGED 221

  Fly   205 LFLDKAGGQLSPQWEEDDDPSHQLKEQLLHQQQPHAANGGSSSGNH------------------- 250
            |.|...||:        |.|...:..|.:.:....|.:|..:.|:|
Zfish   222 LGLRIVGGK--------DTPLGNIVIQEIVRDSLVARDGKLAPGDHILEVNDVSLASISHSRAIA 278

  Fly   251 ---QPFARSGRLSMQFLGDGNGYKWMEAAEKLQNQPPAQQTYQQGSHHAGHGQNGAYSSKSLPRE 312
               ||.:|.....||    ..|:|   ...:...||.|....|..|.:..||
Zfish   279 VIRQPCSRLRLTVMQ----EKGFK---PRPEHHTQPSASPPTQSPSTNQNHG------------- 323

  Fly   313 SKRKEPLGQAYESIREKDGEMLLIINEYGSPLGLTALPDKEHGGGLLVQHVEPGSRAERGRLRRD 377
                            ...::.|:.:|....||:..:...|..|..::..:..|..|:.|:||.:
Zfish   324 ----------------TVIQVTLVKHERSEALGIKLIRKSEEPGVFILDLLPGGLAAKDGKLRNN 372

  Fly   378 DRILEINGIKL-IGLTESQVQEQLRRALESSELRVR--VLR--------GDRNRRQQRDSKVAEM 431
            |::|.|||..| .|..||..|     .:::||:||.  |:|        |:...|..|  :|.|.
Zfish   373 DKVLGINGQDLRHGTPESAAQ-----IIQASEMRVNFVVMRLQDVSEEGGEGQSRGAR--RVPEP 430

  Fly   432 VEVATVSPTRKPHAAPVGTSLQVANTRKLGRKIEIMLKKGP-NGLGFSVTTRDNPAGGH-C---- 490
            ......|...|  ..|.|.|.|         :..:.|||.| ..||.::      |||. |
Zfish   431 QYFRRHSEYMK--EPPGGFSSQ---------EKTVTLKKEPRQSLGITI------AGGRDCRSRL 478

  Fly   491 PIYIKNILPRGAAIEDGRLKPGDRLLEVDGTPMTGKTQTDVVAILRGMPAGATVRIVVSRQQELA 555
            |:||.::.|.|....||.:|.||.||.::|..:|..|..:.|.:|:...|.:||.:.|.  |..|
Zfish   479 PVYITSVQPVGCLHRDGTVKTGDVLLSINGIDLTHLTYNEAVTVLKTQTAQSTVTLRVI--QTFA 541

  Fly   556 EQADQPAEKSAGVAVAPSVAPPAVPAAAAPAPPIPVQKSSSARSLFTHQQQSQLNESQHFIDAGS 620
            :..:|..|                               |.:|.                 |..:
Zfish   542 DDEEQDGE-------------------------------SGSRE-----------------DMDT 558

  Fly   621 ESAASNDSLP-----------PSSNSWHSREELTLHIPVHDTEKAGLGVSVKGKTCSNLNASGSS 674
            .....:|.:.           ||...| .|:     |.:..|.....|.|:.|
Zfish   559 MEGPKDDDINWVPLWTRWLGLPSCIHW-CRD-----IMLMKTNSESWGFSIVG------------ 605

  Fly   675 ASSGSNGLMKHDGDLGIFVKNVIHGGAASRDGRLRMNDQLLSVNGVSLRGQNNAEAMETLR---- 735
                  |..:..|....|:|.::.|..|..||||:..|::::||||:..|.||:..:..|:
Zfish   606 ------GYEESRGQQPFFIKTIVPGTPAYFDGRLKCGDEIVAVNGVTTVGMNNSSLIPMLKLQKN 664

  Fly   736 ---RAMVNTPG 743
               ..:|:.||
Zfish   665 KVTLTVVSWPG 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873	5/26 (19%)
		PDZ_signaling	341..412	CDD:238492	22/71 (31%)
		CRS1_YhbY	<390..>436	CDD:294440	15/55 (27%)
		PDZ_signaling	462..548	CDD:238492	30/91 (33%)
		PDZ_signaling	<686..753	CDD:238492	21/65 (32%)
lnx2b	NP_998105.2	RING	46..82	CDD:214546
		PDZ_signaling	210..291	CDD:238492	16/88 (18%)
		PDZ_signaling	325..406	CDD:238492	25/85 (29%)
		PDZ_signaling	451..537	CDD:238492	30/91 (33%)
		PDZ_signaling	587..671	CDD:238492	25/106 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900