DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment baz and ush1c

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_009296312.1	Gene:	ush1c / 564412	ZFINID:	ZDB-GENE-060312-41	Length:	586	Species:	Danio rerio

Alignment Length:	595	Identity:	129/595 - (21%)
Similarity:	214/595 - (35%)	Gaps:	181/595 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 DSPERLFLDKAGGQLSP-----QWEE-DDDPSHQLKEQLLHQQQPH----AANGGSSSGNHQPFA 254
            :.|:||.|..|...|.|     |::: ....|.:|||..|.:..|.    :..||...|
Zfish    51 NEPKRLPLFDAIRPLIPLKHQVQYDQLTPKRSRKLKEVRLDRTHPEGLGLSVRGGLEFG------ 109

  Fly   255 RSGRLSMQFLGDG----------------NGYKWMEAA-EKLQNQPPAQQTYQQGSHHAGHGQNG 302
             ||....|.:.||                |||...... |::.|....::|......|.|
Zfish   110 -SGLFISQIVKDGQAGNVGLQVGDEIVRINGYSISSCIHEEVINLIKTKKTVSLKVRHVG----- 168

  Fly   303 AYSSKSLPRESKRKEPL------------GQAYES-----------IREKDGEMLLIINEYGSPL 344
                 .:|.:|...|||            |:...|           |:||. ..|.::...|..:
Zfish   169 -----MIPVKSSSDEPLKWQFVDQFVSESGEKSNSIAGLASIGGNEIKEKK-VFLSLVGTKGMGI 227

  Fly   345 GLTALPDKEHGGGLLVQHVEPGSRAERGRLRRDDRILEINGIKLIGLTESQVQEQLRRALESSEL 409
            .:::.|.|:  .|:.|.:|:|||.:....|:..|:|:|:||::...|:.   ||.:|....|..|
Zfish   228 SISSGPTKK--PGIYVSNVKPGSLSAEVGLQVGDQIVEVNGVEFTNLSH---QEAVRVLKSSRSL 287

  Fly   410 RVRVLRGDRNRRQQRDSKVAEMVEVATVSPTRKPHAAPVGTSLQVANTRKLGRKIEIMLKKGPNG 474
            .:.||.|..:.....|.:                       .|.|....:|.|: |:|.:|
Zfish   288 TITVLTGAGSELFMTDEE-----------------------RLAVEARHELDRQ-ELMHQK---- 324

  Fly   475 LGFSVTTRDNPAGGHCPIYIKNILPRGAAIEDGRLKPGDRLLEVDGTPMTGKTQTDVVAILRGMP 539
                                |..|.....:::.:.|...|.:|:     :.|...:.....:.|.
Zfish   325 --------------------KVALETNKIVKEQQEKERQRKMEI-----SQKAAEEEERYRKEME 364

  Fly   540 AGATVRIVVSRQQELAEQADQPAEKSAGVAVAPSVAP-PAVPAAAAPAPPIPVQKSSSARSLFTH 603
                 ||..:.::...|..|....|....:|:|:.:| |..|...||:|.   .|:|:|.|
Zfish   365 -----RIEAAEKKHHKEWEDDWGSKEKKKSVSPAASPSPPPPTRLAPSPK---PKTSTADS---- 417

  Fly   604 QQQSQLNES-QHFIDAGSESAASNDSLPPS---SNSWHSREELTLHIPVHDTEKAG-LGVSVKGK 663
             .:.:..|. |.::|         |..|.|   :.....|:...|.|     :|.| |.::::|
Zfish   418 -YEEETGEGFQKYVD---------DFDPHSMFTAEQIAGRDVRLLRI-----KKEGKLDLAIEG- 466

  Fly   664 TCSNLNASGSSASSGSNGLMKHDGDLG-IFVKNVIHGGAASRDGRLRMNDQLLSVNGVSLRGQNN 727
                             |:   |..|| |.|.::..||||.:.|.:...|::::|||..|.....
Zfish   467 -----------------GI---DSPLGKIVVSSIYEGGAADKHGGVVSGDEIMAVNGKILTDVTL 511

  Fly   728 AEAMETLRRA 737
            ||...::.:|
Zfish   512 AEGQTSMAQA 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873
		PDZ_signaling	341..412	CDD:238492	21/70 (30%)
		CRS1_YhbY	<390..>436	CDD:294440	10/45 (22%)
		PDZ_signaling	462..548	CDD:238492	13/85 (15%)
		PDZ_signaling	<686..753	CDD:238492	18/53 (34%)
ush1c	XP_009296312.1	harmonin_N	2..80	CDD:259819	8/28 (29%)
		PDZ_signaling	85..165	CDD:238492	19/86 (22%)
		PDZ_signaling	212..292	CDD:238492	24/85 (28%)
		RILP-like	317..>379	CDD:304877	14/96 (15%)
		PDZ_signaling	447..534	CDD:238492	26/101 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900