DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment baz and PARD3

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	NP_062565.2	Gene:	PARD3 / 56288	HGNCID:	16051	Length:	1356	Species:	Homo sapiens

Alignment Length:	1628	Identity:	418/1628 - (25%)
Similarity:	627/1628 - (38%)	Gaps:	537/1628 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 PDSWVTVTHLQ-TQSGILDPDDCVRDVADDREQILAHFDDPGPDPGVPQGGGDGASGSSSVGTGS 125
            |:.|:.|..|: ...||||.||.:.|||||:::::|.||:..     |..||||.| :||.||.|
Human    42 PNYWIQVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQD-----PHHGGDGTS-ASSTGTQS 100

  Fly   126 PDIFRDP--TNTEAPTCPRDLSTPHIEVTSTTSGPMAGLGVGLMVRRSSDPNLLA-SLKAEGSN- 186
            |:||...  ||..:...|.. :|..||||.:    :....:.|.|||||||.|:. |.....||
Human   101 PEIFGSELGTNNVSAFQPYQ-ATSEIEVTPS----VLRANMPLHVRRSSDPALIGLSTSVSDSNF 160

  Fly   187 ----------KRWSAAAPHYAGGDSPERLFL--DKAGGQLSPQWEEDDDPSHQLKEQLLHQQQPH 239
                      .|||..|.           ||  :.||...:...::|::          ::..|.
Human   161 SSEEPSRKNPTRWSTTAG-----------FLKQNTAGSPKTCDRKKDEN----------YRSLPR 204

  Fly   240 AANGGSSSGNHQPFARSGRLSMQFLGDGNGYKWMEAAEKLQNQPPAQQTYQQGSHHAGHGQNGAY 304
            ..:..|:.........|...|...:|     ||:|..|  |::...::
Human   205 DTSNWSNQFQRDNARSSLSASHPMVG-----KWLEKQE--QDEDGTEE----------------- 245

  Fly   305 SSKSLPRESKRKEPLGQAYESIRE------KDGEMLLIINEYGSPLGLTALPDKEHGG---GLLV 360
                   ::.|.||:|.|...:..      .|...|:.:...|.|||:..:|....||   ||||
Human   246 -------DNSRVEPVGHADTGLEHIPNFSLDDMVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLV 303

  Fly   361 QHVEPGSRAERGRL-RRDDRILEINGIKLIGLTESQVQEQLRRALE------------SSELRVR 412
            :.:|.|.:||...| |.:|.|:.||...|......|.|...|:|:.            :.|...:
Human   304 KRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQ 368

  Fly   413 VLRGDRNR---------RQQRDSKVAEMVEVATVS-----------------------PTRKPHA 445
            :.:.::|.         .|..|::......:.||.                       |:.||.:
Human   369 LSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAPRLNHPPEQIDSHSRLPHSAHPSGKPPS 433

  Fly   446 APVGTSLQV--------ANTRKLGRKIEIMLKKGPNGLGFSVTTRDNPAGGHCPIYIKNILPRGA 502
            ||......|        .||:|:|:::.|.||||..|||||:|:||...||..|||:||||||||
Human   434 APASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGA 498

  Fly   503 AIEDGRLKPGDRLLEVDGTPMTGKTQTDVVAILRGMPAGATVRIVVSRQQELAEQADQPAEKSAG 567
            ||:|||||.||||:||:|..:.||:|.:||::||......||.::|.||    |.|..|.|.:|
Human   499 AIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQ----EDAFHPRELNA- 558

  Fly   568 VAVAPSVAPPAVPAAAAPAPPIPVQKSSSARSLFTHQQQSQLNESQHFIDAGSESAASNDS--LP 630
               .||                                |.|:.:         |:.|.::.  |.
Human   559 ---EPS--------------------------------QMQIPK---------ETKAEDEDIVLT 579

  Fly   631 PSSNSWHSREELTLHIPVHDTEKAGLGVSVKGKTCSNLNASGSSASSGSNGLMKHDGDLGIFVKN 695
            |..    :||.||..:|::|:..|||||||||                 |...::..|||||||:
Human   580 PDG----TREFLTFEVPLNDSGSAGLGVSVKG-----------------NRSKENHADLGIFVKS 623

  Fly   696 VIHGGAASRDGRLRMNDQLLSVNGVSLRGQNNAEAMETLRRAMVNTPGKHPGTITLLVGRKILRS 760
            :|:|||||:|||||:||||::|||.||.|:.|.:|||||||:| :|.|...|.|.|:|.|:|.:.
Human   624 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSM-STEGNKRGMIQLIVARRISKC 687

  Fly   761 ASSSDILDHSNSHSHSHSNSSGGSNSNGSGNNNNSSSNASDNSGATVIYLSPEKREQRCNGGGGG 825
                                            |...|..|.......|..:.:.||:|.:.....
Human   688 --------------------------------NELKSPGSPPGPELPIETALDDRERRISHSLYS 720

  Fly   826 GSAGNEMNRWSNPVLDRLTGGICSSNSAQPSSQQSHQQQPHPSQQQQQQRRLPAAPVCSSAALRN 890
            |..|.:.:...|..|.|:.|             :|.:.|..|:....|
Human   721 GIEGLDESPSRNAALSRIMG-------------ESGKYQLSPTVNMPQ----------------- 755

  Fly   891 ESYYMATNDNWSPAQMHLMTAHGNTALLIEDDAEPMSPTLPARPHDGQHCNTSSANPSQNLAVGN 955
                                   :..::||||..|:.|     ||.....::||.:
Human   756 -----------------------DDTVIIEDDRLPVLP-----PHLSDQSSSSSHD--------- 783

  Fly   956 QGPPINTVPGTPSTSSNFDATYSSQLSLETN-SGVEHFSRDALGRRSISEKHHAALDARETGTYQ 1019
               .:..|.....|.:....:.|:..||..: ..|..|.|:..||:|:|||
Human   784 ---DVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQSMSEK-------------- 831

  Fly  1020 RNKKLREERERERRIQLTKSAVYGGSIESLTARIASANAQFSGYKHAKTASSIEQRETQQQLAAA 1084
            |.|:..:..:.: .::..||       :|:...||.                    ||:.. ...
Human   832 RTKQFSDASQLD-FVKTRKS-------KSMDLGIAD--------------------ETKLN-TVD 867

  Fly  1085 EAEARDQLGDLGPSLGMKKSSSLESLQTMVQELQMS-DEPRGHQALRAPRGRGREDSLRAAVVSE 1148
            :.:|.....|:|||||:|||||||||||.|.|:.:: |.|......|..||||..:|.|||:...
Human   868 DQKAGSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPRPRIIRGRGCNESFRAAIDKS 932

  Fly  1149 PDASKPRKTWLLEDGD------HEGGFASQRNG-------------PFQSSLNDGKH-GCKSSRA 1193
            .|  ||    .::|.|      .|....|.|:|             ..:..:|..:. |.|:.|.
Human   933 YD--KP----AVDDDDEGMETLEEDTEESSRSGRESVSTASDQPSHSLERQMNGNQEKGDKTDRK 991

  Fly  1194 K--------------------KPSILRGIGHMFRFGKNRKDGVVPVDNYAVNISPPTSVVSTATS 1238
            |                    |..:|:|:|.||||||:|||.       .:..:....:..:.||
Human   992 KDKTGKEKKKDRDKEKDKMKAKKGMLKGLGDMFRFGKHRKDD-------KIEKTGKIKIQESFTS 1049

  Fly  1239 PQLQQQQQQQLQQHQQQQQIPTAALAALERNGKPPAYQPPPPLPAPNGVGSNGIHQNDIFNHRYQ 1303
                  ::::::..|:|::|........||..                              |.:
Human  1050 ------EEERIRMKQEQERIQAKTREFRERQA------------------------------RER 1078

  Fly  1304 HYANYEDLHQQH--QQHQISGGDSTTSISETLS---ESTLECMRQQVIRQRIKVEAES------- 1356
            .||..:|.|:..  ....:.||.|:...|..|:   :|..|......:..::|....|
Human  1079 DYAEIQDFHRTFGCDDELMYGGVSSYEGSMALNARPQSPREGHMMDALYAQVKKPRNSKPSPVDS 1143

  Fly  1357 ------------RRHQHYHSQRSARSQDV-SMHSTSSGSQPGSLAQPQAQSNGVRPMSSYYEYET 1408
                        |..|.:  |::.:.:|| ....|.|..||...|:|..|| |...:|     ..
Human  1144 NRSTPSNHDRIQRLRQEF--QQAKQDEDVEDRRRTYSFEQPWPNARPATQS-GRHSVS-----VE 1200

  Fly  1409 VQQQRVGSIKHSHSSSA----------TSSSSSPINVPHWKAAAMNGYSPASLNSSAR------- 1456
            ||.||....:...|..|          :..::|.::...|:    ..|||.....||:
Human  1201 VQMQRQRQEERESSQQAQRQYSSLPRQSRKNASSVSQDSWE----QNYSPGEGFQSAKENPRYSS 1261

  Fly  1457 ---SRGPFV------------TQVTIREQSSGGIPAHLLQQHQQQQLQQQQPTYQTVQKMSGPSQ 1506
               ||..::            ||..:|::          |:.::||:::|.|:       .|||.
Human  1262 YQGSRNGYLGGHGFNARVMLETQELLRQE----------QRRKEQQMKKQPPS-------EGPSN 1309

  Fly  1507 YGS 1509
            |.|
Human  1310 YDS 1312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873	46/114 (40%)
		PDZ_signaling	341..412	CDD:238492	27/86 (31%)
		CRS1_YhbY	<390..>436	CDD:294440	8/66 (12%)
		PDZ_signaling	462..548	CDD:238492	49/85 (58%)
		PDZ_signaling	<686..753	CDD:238492	42/66 (64%)
PARD3	NP_062565.2	DUF3534	1..146	CDD:288873	46/114 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..100		10/24 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..262		26/159 (16%)
		PDZ_signaling	272..347	CDD:238492	26/74 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	408..448		6/39 (15%)
		PDZ_signaling	465..544	CDD:238492	47/78 (60%)
		PDZ_signaling	588..681	CDD:238492	55/110 (50%)
		Interaction with PRKCI and PRKCZ. /evidence=ECO:0000250\|UniProtKB:Q9Z340	712..936		76/338 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	865..886		7/20 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	932..1025		19/98 (19%)
		Interaction with FRMD4A. /evidence=ECO:0000250\|UniProtKB:Q99NH2	935..1356		90/454 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1129..1356		45/213 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159667
Domainoid	1	1.000	103	1.000	Domainoid score	I6782
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	353	1.000	Inparanoid score	I2258
Isobase	1	0.950	-	0.946395	Normalized mean entropy	S7653
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D387987at33208
OrthoFinder	1	1.000	-	-		FOG0002688
OrthoInspector	1	1.000	-	-		otm42201
orthoMCL	1	0.900	-	-		OOG6_107739
Panther	1	1.100	-	-	O	PTHR16484
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2449
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.710