DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment baz and grid2ipb

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_009304908.1	Gene:	grid2ipb / 559717	ZFINID:	ZDB-GENE-040724-161	Length:	1383	Species:	Danio rerio

Alignment Length:	1486	Identity:	264/1486 - (17%)
Similarity:	438/1486 - (29%)	Gaps:	610/1486 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   267 GNGYKWMEAAE-----KLQNQPPAQQTYQQGSHHAGHGQNGAYSSKSLPRESKRKEPLGQAYESI 326
            |:|..::...|     :|....|..|..:.      .|||  .||.|    ::....|.|:..:|
Zfish    18 GHGPSYILTVEEGSSAQLSGLQPGDQVLEI------EGQN--VSSLS----AQEVIALAQSQRNI 70

  Fly   327 REKDGEMLLIINEYGSPLGLTALPDKEHG----GG--LLVQHVEPGSRAERGRLRRDDRILEING 385
            ....|.:..|     ..:.:|..||...|    |.  |||:...|.|.|.|..||..|.::|:||
Zfish    71 PPSIGVVSRI-----QQMDITPGPDGRFGFTIVGDCPLLVEDCSPCSPAGRSGLRAGDYVMEVNG 130

  Fly   386 I------------------------------------KLIGL---TESQVQEQLRRALESSELRV 411
            |                                    .|.||   |:...|::..:|||.:....
Zfish   131 IPVKHHEMAAALIKASQGRTLRLGVLCMGSRQKRSSGSLEGLQKDTDGMRQDRKHKALEFNRRVE 195

  Fly   412 RVLRGD------------------------------------------------RNRRQQRDSKV 428
            .:||.:                                                :..||:.|..|
Zfish   196 EILRNEPEVKEKLFAVLKQFAAERKVDWLASVLPDILTTEEQQQLISNIRIFIPKKHRQRFDEAV 260

  Fly   429 AE-----MVEVATV---------SPTRKPHAAPVGTSLQVANTRKLG----------RKIEIMLK 469
            ::     |....::         |.::..|..|.|:....:..|..|          ||...|:.
Zfish   261 SQSLINRMCRSKSLGEPQNRLRRSRSQDHHERPQGSKRASSVPRDTGDEPAQNDRTLRKSNTMIP 325

  Fly   470 ---------------KGPNGLGFSVTTRDNPAGGHCPIYIKNILPRGAAIEDGRLKPGDRLLEVD 519
                           :|....||::.       ||.|::|.:::| |:..|...||.|||:|.::
Zfish   326 TQYVSGVNQRTIRVYRGKKSFGFTLR-------GHAPVWIDSVMP-GSPAEACGLKTGDRILFLN 382

  Fly   520 GTPMTGKTQTDVVAILRGMPAGATVRIVVSRQQELAEQADQPAEKSAGVAVAPSVAPPAVPAAAA 584
            |..|...:...||::|:|  :||...:||........|:|...|::           |:.|.:.:
Zfish   383 GLDMRNCSHEKVVSMLQG--SGAMPSLVVEEGPVDYPQSDSEPEET-----------PSAPRSRS 434

  Fly   585 PAPPIPVQKSSSARSLFTHQQQSQLNESQHFIDAGSESAASNDSLPPSSNSWHSREELTLHIPVH 649
            ||             |.:.|..:::                   ||||
Zfish   435 PA-------------LSSLQWVAEI-------------------LPPS----------------- 450

  Fly   650 DTEKAGLGVSVKGKTCSNLNASGSSASSGSNGLMKHDGDLGIFVKNVIHGGAASRDGRLRMNDQL 714
                    :.|.|:|.|                                          :..:.|
Zfish   451 --------IRVHGRTFS------------------------------------------QQLEHL 465

  Fly   715 LSVNGVSLRGQNNAEAMETLRR------------AMVNTPGK-----------------HPGTIT 750
            |::.    ......:|:||..:            .:::||.|                 |..|
Zfish   466 LTLQ----ERYTICKALETFFQHRNVDTLIVDVFPVLDTPAKQLIWQFIYQLLTYEEQEHCKT-- 524

  Fly   751 LLVGRKILRSASSSDILDHSNSHSHSHSNSSGGSNSNGSGNNNNSSSNASDN--------SGATV 807
                 ||.|............:.:|..|:|   ...:|:.:.|.....:||:        .|...
Zfish   525 -----KIARFLGFKSAEPEVGAETHRRSSS---MRVSGTSHKNTVRERSSDDCIIGTHLGMGTFT 581

  Fly   808 IYLSPEKREQRCNGGGGGGSAGNEMNRWSNPVLDRLTGGICSSNSAQPSSQQSHQQQPHPSQQQQ 872
            ..::||:|:  |    |.|::..|     :|.|..:||......:..
Zfish   582 DPVTPEERQ--C----GDGTSFPE-----SPDLSHMTGVYTELGNVY------------------ 617

  Fly   873 QQRRLPAAPVCSSAALRNESYYMATNDNWSPAQMHLMTAHGNTALLIEDDAEPMSPTLPARPHDG 937
                    ||.||.:|::.|         ||....:..|..||                   :..
Zfish   618 --------PVKSSQSLQSHS---------SPRAAGMGLAESNT-------------------YTQ 646

  Fly   938 QHCNTSSANPSQNLAV----GNQGPPINTVPGTPSTSSNFDATYSSQLSLETNSGVEHFSRDALG 998
            ...::::.|....|::    ...||...|          :..|.:|..|:::|..|
Zfish   647 SFTHSTAGNRKSGLSLTWTDSFPGPQFET----------YQQTVASPDSVDSNPYV--------- 692

  Fly   999 RRSISEKHHAALDARETGTYQRNKKL----REERERERRIQLTKSAVYGGSIESLTARIASANAQ 1059
              |:.....:.|.:.|.....:.:||    |..|.|:....|...:      |.|..|:...: .
Zfish   693 --SLDSPPASPLPSDELSPLPQRRKLFTFSRPPRSRDTDKFLDALS------EQLGHRVNIVD-D 748

  Fly  1060 FSG----YKHAKTASSIEQRETQQQLAAAEAEARDQLGDLGPSLGMKKSSSLESLQTMVQE---- 1116
            |.|    |:........|......:|::|.:|......|   |..:..||..:.:....|.
Zfish   749 FKGGENDYEEMSFQDEQEVNMLPHELSSASSEDHSSSDD---STSVSYSSGSDHIPPPPQSPPPP 810

  Fly  1117 ---LQMSDEPR----------------GHQALRAPRGRGREDSLRAAVVSEPDASK--PRKTWLL 1160
               ||.:|.|.                .|..:.||    .....|..:.:.|...|  |.:..|.
Zfish   811 PPPLQFTDSPSPLPITPEHLPQPPPAFQHHPIIAP----PPPPPRPFLANRPSLHKVLPTREELR 871

  Fly  1161 EDGDHEGGFASQRNGPFQSS--------------LNDGKH--------GCKSSRAKKPSILRGIG 1203
            ....|     .:|:.|..||              |....|        ..:.:|.:.||
Zfish   872 AQHSH-----PRRSSPQPSSQPILQLHQPKAHPILQSSPHTSPQPPHTSAQHTRLQHPS------ 925

  Fly  1204 HMFRFGKNRKDGVVPVDNYAVNISPPTSVVSTATSPQLQQQQQQQLQQHQQQQQIPTAALAALER 1268
                              .::..|..|:|  ..|||.|.:|:....|..||..:   ..|::...
Zfish   926 ------------------QSIYQSQQTTV--PRTSPSLTKQKSLHSQPSQQSFE---GTLSSKVP 967

  Fly  1269 NGKPPAYQP---PPPLPAPNGVGSNGIHQNDIFNHRYQHYANYE-----DLHQQHQQHQISGGDS 1325
            ...||...|   |||||.|:...|:..|.: :...|::...|.|     .|......|::|.
Zfish   968 PPPPPPLPPPCDPPPLPKPSPKASDNNHMS-VKRLRWEQVENSEGTIWGQLGDDPDYHKLSD--- 1028

  Fly  1326 TTSISETLSESTLECMRQQVIRQRIKVEAESRRHQHYHSQRSARSQDVSMHSTSSGSQPGSLAQP 1390
                                                     ..:..|:.::   .|:|..|::.|
Zfish  1029 -----------------------------------------MVKYLDLDLY---FGTQRNSISLP 1049

  Fly  1391 QAQSNGVRPMSSYYEYETVQQQRVGSIKHSHSSSATSSSSSPINVPHWKAAAMNGYSPASLNSSA 1455
            :..          :..|.::::.|..|. ||..:..:|    |.:.|.|.|      |..|
Zfish  1050 EPT----------FLPENLKKKDVVEIL-SHKKAYNAS----ILIAHLKLA------PKEL---- 1089

  Fly  1456 RSRGPFVTQVTIREQSSGGIPAH----LLQQHQQQQLQQQQPTYQTVQKMSGPSQY 1507
              |...:|..|.|.:     |||    ||.....::::|.|...|...|:|.|.|:
Zfish  1090 --RDILMTMSTERLE-----PAHIKQLLLYAPDDEEVKQFQHYDQDPAKLSEPDQF 1138

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873
		PDZ_signaling	341..412	CDD:238492	27/115 (23%)
		CRS1_YhbY	<390..>436	CDD:294440	14/101 (14%)
		PDZ_signaling	462..548	CDD:238492	27/100 (27%)
		PDZ_signaling	<686..753	CDD:238492	10/95 (11%)
grid2ipb	XP_009304908.1	PDZ_signaling	9..69	CDD:238492	14/62 (23%)
		PDZ_signaling	80..156	CDD:238492	20/80 (25%)
		HN_L-delphilin-R1_like	183..262	CDD:259820	9/78 (12%)
		PDZ_signaling	335..410	CDD:238492	25/84 (30%)
		HN_L-delphilin-R2_like	451..530	CDD:259821	17/131 (13%)
		FH2	995..1360	CDD:280362	40/224 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900