DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment baz and grip1

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_009298419.1	Gene:	grip1 / 558006	ZFINID:	ZDB-GENE-041210-125	Length:	1191	Species:	Danio rerio

Alignment Length:	1278	Identity:	247/1278 - (19%)
Similarity:	394/1278 - (30%)	Gaps:	438/1278 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   286 QQTYQQGSHHAGHGQNGAYSSKSLPRE------SKRKEPLGQAYESIREKDGEMLLIINEYGSPL 344
            :..|...|.|..|  .|.|:..|.|..      :.|::.:...:     |....:.:|.:.|:.|
Zfish    33 EDVYYYASEHLHH--EGPYTKHSNPSRPPDGALAIRRQSIPDEF-----KGTSTVELIKKEGTTL 90

  Fly   345 GLTALPDKEHGGGLLVQHVEPGSRAERG-RLRRDDRILEINGIKLIGLTESQVQEQLRRALESSE 408
            |||.....:..|...|.::..|..|.|. :|...|.|..:|||.|......::...|:...|...
Zfish    91 GLTVSGGIDKDGKPRVSNLRQGGIAARSDQLNVGDYIKSVNGINLTKFRHDEIISLLKNVGERVV 155

  Fly   409 LRVRVLRGDRNRRQQRDSKVAEMVEVATVSPTRKPHAAPVGTSLQVANTRKLGRKIEIMLKKGPN 473
            |.|.                   .|:..||               |..:..:.:.:|:.|.|..|
Zfish   156 LEVE-------------------YELPPVS---------------VQGSGVMFKNVEVTLHKEGN 186

  Fly   474 GLGFSVTTRDNPAGGH------CPIYIKNILPRGAAIEDGRLKPGDRLLEVDGTPMTGKTQTDVV 532
            ..||.:.     .|.|      .|:.|..|.|.|.|..:|.:|||||||.:||..:.|.:..:.:
Zfish   187 TFGFVIR-----GGAHEDRNKSRPVTITTIRPGGPADREGTIKPGDRLLSIDGIRLHGASHAEAM 246

  Fly   533 AILRGMPAGATVRI---------VVSRQQELAEQADQPAEKSAGVAVAPS------------VAP 576
            :||:.....||:.|         |.:....|..:..:....|.|:|::.|            |.|
Zfish   247 SILKQCGQEATLLIEYDVSVMDSVATASGPLLVEVAKSMGSSLGLALSTSMYCNKQVIIIDKVKP 311

  Fly   577 PAVP----------------------AAAAPAPPIPVQKSSSAR-SLFTHQQ------------- 605
            .::.                      ...|.|..:....|...: .:..|.|
Zfish   312 ASIADRCGALHAGDHILSVDGTSMEYCTLAEATQLLASASEHVKMEILPHHQTRLALKGPEHVKV 376

  Fly   606 ---------QSQLNESQHFI--------------DAGSESAASN----DSLPPSSNSWHSREEL- 642
                     :|..|.:.:|:              ....:::.||    .|..|:|.|.:|...|
Zfish   377 QRSTRPLPWESGTNNNSNFLPYQHYNTYHPDQSHSQAKKTSPSNPPLGSSFSPTSMSAYSLSSLN 441

  Fly   643 --TLHIPVHDTEKAGLGVSVKGKTCSNLNASGSSASS--GSNGLMKH----------DGDLGIFV 693
              ||...::.|...|..:..|.|. .:..:|.|.|||  |..|.:.|          |..:|..:
Zfish   442 MNTLPRTMYPTSPRGTMMRRKLKK-KDYKSSMSLASSTVGLAGQVVHTETTEVTLISDSIMGFGI 505

  Fly   694 KNVIHGGA--------------------ASRDGRLRMNDQLLSVNGVSLRGQNNAEAMETLRRAM 738
            :  :.||.                    |.|.|.|::.|::||:||:........|..:.||.:.
Zfish   506 Q--LQGGVFATETLSSPPLIAYIDPDSPAERCGILQIGDRILSINGIPTEDSTLEETNQLLRDSS 568

  Fly   739 VNT----------------------------PG------------KHPG---------------- 747
            :.:                            ||            :.||
Zfish   569 ITSKVTLEIEFDVAESVIPSSGTFHVKLPKKPGVELGITISSPSSRKPGDALIISDIKKGSVAHR 633

  Fly   748 TITLLVGRKILR-------SASSSDIL----------------DHSNSHSHSHSNSSGGSNSNGS 789
            |.||.:|.|:|.       :.|..|.:                |..||          |....||
Zfish   634 TGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDEDNS----------GVLRAGS 688

  Fly   790 GNNN-----NSSSNASDNSGATVIYLSPEKREQRCNGGGGGGSAGNEMNRWSNP----VLDRLT- 844
            .:.|     ...::..:.||| :||....||.        ||..|..::....|    ::..||
Zfish   689 VDRNARVLLACVADEQETSGA-IIYTVELKRY--------GGPLGITISGTEEPFDPIIISSLTK 744

  Fly   845 GGICSSNSAQPSSQQSHQQQPHPSQQQQQQRRLPAAPVCSSAALRNESYYMATNDNWSPAQ---- 905
            ||:..                                  .:.|:......:|.|.|....:
Zfish   745 GGLAE----------------------------------RTGAIHIGDRILAINSNSLKGKPLSE 775

  Fly   906 -MHLMTAHGNTALL-IEDDAE---PMSPTLPAR-------PHDGQHCNTSSANPSQNLAVGNQGP 958
             :||:...|.:..| |:...|   |..|::..|       ..|||.....|...|
Zfish   776 AIHLLQMAGESVTLKIKKQGELPSPKPPSVTGRLNNLSDLEDDGQKAGKLSDIYS---------- 830

  Fly   959 PINTVPGTPST-----SSNFDATYSSQ----LSLETNSGVEHFSRDAL-GRRSISEKHHAALDAR 1013
              .|:|...|.     .|..|||:|:|    ......|...|..|:|. .|.|:|..:
Zfish   831 --TTIPSVDSAVESWDGSAIDATFSTQAPTGFQASGYSFHSHEWRNAKPSRGSLSPVN------- 886

  Fly  1014 ETGTYQRNKKLREERERERRIQLTKSAVYGGSIESLTARIASANAQF-------SGYKHAKTASS 1071
              .:.|||..|.:               :|..::......||..:..       |.:......:.
Zfish   887 --SSRQRNNILPD---------------FGIGVDDWDRPSASGASTLPTGLISDSRFTVGHDGTE 934

  Fly  1072 IEQRETQQQLAAAEAEARDQLGDL-----GPSLGMKKSSSLESLQTMV--QELQMSDEP---RGH 1126
            .:|.|.....|..:.|...|.|.|     .|...:.| .:|..|.|::  ..|.::.:|   |.|
Zfish   935 PDQEENFWSQALEDLETCGQSGILRELEDKPDRLLNK-RNLAILATIMSGSSLSLNHDPAPTRSH 998

  Fly  1127 QALRAPRGRGREDSLRAAVVSEPDASKPRKTWLLEDGDHEGGFASQRNGPFQSSLNDGKHGCKSS 1191
                    .||:.|.:....::|..|:..::..|........||.:|.          |...|..
Zfish   999 --------LGRQASFQERGSNKPQYSQANRSNTLPTDVGRKAFAMRRM----------KQEIKDI 1045

  Fly  1192 RAKKP------SILRGIGHMFRFGKNRKDGVVPVDNYAVNISP--PTSVVSTATSPQLQQQQQQQ 1248
            .:..|      |:|:. ..:..||.:..|||:....|..||.|  |..:.......:|.|....:
Zfish  1046 MSPTPVELHKVSLLKD-SDLEDFGFSVSDGVLEKGVYVNNIRPGGPAEIGGLKPYDRLLQINHVR 1109

  Fly  1249 LQQHQQQQQIPTAALA------ALERNGKPPAYQPPPPLPAPN 1285
            .:.......:|..|.:      .:.||  |.:.||....|..|
Zfish  1110 TRDFDCCLVVPLIAESGNKLDLVISRN--PVSSQPSELNPLSN 1150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873
		PDZ_signaling	341..412	CDD:238492	20/71 (28%)
		CRS1_YhbY	<390..>436	CDD:294440	5/45 (11%)
		PDZ_signaling	462..548	CDD:238492	30/100 (30%)
		PDZ_signaling	<686..753	CDD:238492	23/142 (16%)
grip1	XP_009298419.1	PDZ_signaling	79..159	CDD:238492	21/79 (27%)
		PDZ_signaling	178..261	CDD:238492	29/87 (33%)
		PDZ_signaling	276..359	CDD:238492	10/82 (12%)
		PDZ_signaling	490..578	CDD:238492	16/89 (18%)
		PDZ_signaling	591..675	CDD:238492	12/83 (14%)
		PDZ_signaling	711..792	CDD:238492	20/122 (16%)
		PDZ_signaling	1053..1133	CDD:238492	16/80 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900