DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment baz and lnx2a

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	NP_001106696.2	Gene:	lnx2a / 553331	ZFINID:	ZDB-GENE-060228-2	Length:	737	Species:	Danio rerio

Alignment Length:	789	Identity:	170/789 - (21%)
Similarity:	268/789 - (33%)	Gaps:	287/789 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 TCPRDLSTPHIEVTSTTSGPMAGLGVGLMVR---RSSDPNLLASLKAEGSNKRWSAAAPHYA--- 197
            |||   .||    :.:.|.|...|...|..|   ..|....|...:.|||..|.:|..|..:
Zfish   112 TCP---LTP----SCSLSMPRCDLEAHLKHRCPGTQSQRTKLERTQMEGSEDRVTATNPPKSPQT 169

  Fly   198 --GGDSPERLFLDKAGGQLS---PQWEED---DDPS----------HQLKEQLLHQQQP------ 238
              ..|:|.    ..||....   |.|.|:   |:|:          |.|:..|...::|
Zfish   170 EIKEDTPS----PPAGSNACNNVPTWTEEPGIDNPAFEESTEEDSVHGLECALPRVKRPLSNPCI 230

  Fly   239 HAANGGSSSGNHQPFARSGRLSMQFLGDGNGYKWMEAAEKLQNQPPAQQTYQQGSHHAGHGQNGA 303
            |....|||:.:...|..:..||                                      .:.|.
Zfish   231 HLLRTGSSASSGWDFVETLPLS--------------------------------------AEEGC 257

  Fly   304 YSSKSLPRESKRKEPLGQAYESIREKDGEMLLI----INEYGSPLGLTALPDKEHGG------GL 358
            ....|||                   :||:..|    .|.| |.:|::.:     ||      .:
Zfish   258 VKLPSLP-------------------EGEITTIEVHRTNPY-SEMGISIV-----GGNETPLINV 297

  Fly   359 LVQHV-EPGSRAERGRLRRDDRILEINGIKLIGLTESQVQEQLRRALESSELRVRVLRGDRNRRQ 422
            ::|.| ..|..|..|||...|:||::|.:.:..:..:..:..|.|...:.:|.|
Zfish   298 VIQEVYRDGVIARDGRLLAGDQILQVNNVDISNVPHNFARSTLARPCATLQLTV----------- 351

  Fly   423 QRDSKVAEMVEVATVSPTRKPHAAPVGTSLQVANTRKLGRKIEIMLKKGPNGLGFSVTTRDNPAG 487
            .|:.:.:.....||.||...|.:.                :|.:..::....||..:..|.:.||
Zfish   352 LRERRCSARPPAATASPKGSPASI----------------RITLHKRESSEQLGIKLVRRTDEAG 400

  Fly   488 GHCPIYIKNILPRGAAIEDGRLKPGDRLLEVD------GTPMTGKTQTDVVAILRGMPAGATVRI 546
                ::|.::|..|.|.:||||...||:|.|:      |||   :....::     ..:|..|.:
Zfish   401 ----VFILDLLEGGLAAKDGRLCSNDRVLAVNEHDLRHGTP---ELAAQII-----QASGERVNL 453

  Fly   547 VVSR--QQELAEQADQPAEKSA----GVAVAPSVAPPAVPAAAAPAPPIPVQKSSSARSLFTHQQ 605
            ::||  :|.:|........:..    .:...||.|.|      :|.|.:.:.:||:.|.|
Zfish   454 LISRSSKQTMAVHTGSTLTRDIWSHDHIPPLPSTATP------SPVPSLHLARSSTQRDL----- 507

  Fly   606 QSQLNESQHFIDAGSESAASNDSLPPSSNSWHSREELTLHIPVHDTEKAGLGVSVKGKTCSNLNA 670
                                       |...:.:|:   ||.|.......||::|.|
Zfish   508 ---------------------------SQCVNCKEK---HITVKKEPHESLGMTVAG-------- 534

  Fly   671 SGSSASSGSNGLMKHDGDLGIFVKNVIHGGAASRDGRLRMNDQLLSVNGVSLRGQNNAEAMETLR 735
             |..:.|         |:|.|||.:|...|..|||||::..|.|||:||..|...:::||:.||:
Zfish   535 -GRGSKS---------GELPIFVTSVQPHGCLSRDGRIKRGDVLLSINGQDLTYLSHSEAVGTLK 589

  Fly   736 ----------RAMVNTPGKHPGTITLLVGRKIL--------RSASSSDIL-------DHSNSHS- 774
                      :|:..|..:.||     :..::|        .|.|.|.:|       .|| ||.
Zfish   590 SSATSCSVQLKALEVTMVEEPG-----LDEELLPPHENDYDASWSPSWVLWLGLPSYLHS-SHEI 648

  Fly   775 ---HSHSNSSGGSNSNGSGNNNNSSS---------------------------NASDNSGATVIY 809
               .||..|.|.|...|...|:::.:                           |....:|.:...
Zfish   649 VLRRSHPGSWGFSIVGGYEENHSNQAFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTAGMSHSA 713

  Fly   810 LSPEKREQR 818
            |.|..:|||
Zfish   714 LVPMLKEQR 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873	11/37 (30%)
		PDZ_signaling	341..412	CDD:238492	18/77 (23%)
		CRS1_YhbY	<390..>436	CDD:294440	5/45 (11%)
		PDZ_signaling	462..548	CDD:238492	23/91 (25%)
		PDZ_signaling	<686..753	CDD:238492	27/76 (36%)
lnx2a	NP_001106696.2	zf-RING_2	49..87	CDD:290367
		PDZ	267..353	CDD:214570	23/102 (23%)
		PDZ_signaling	375..455	CDD:238492	23/107 (21%)
		PDZ_signaling	515..600	CDD:238492	33/105 (31%)
		PDZ_signaling	646..730	CDD:238492	15/77 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900