DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment baz and PDZK1

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_024303384.1	Gene:	PDZK1 / 5174	HGNCID:	8821	Length:	539	Species:	Homo sapiens

Alignment Length:	586	Identity:	135/586 - (23%)
Similarity:	220/586 - (37%)	Gaps:	170/586 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   310 PRESKRKEPLGQAYESIR--EKDGEMLLIINEYGSPLGLTALPDKEHGGGLLVQHVEPGSRAERG 372
            |||.|..:..||.|....  |||.|                        |.||:.||..|.||:.
Human    27 PRECKLSKQEGQNYGFFLRIEKDTE------------------------GHLVRVVEKCSPAEKA 67

  Fly   373 RLRRDDRILEINGIKLIGLTESQVQEQLRRALESSELRVRVLRGDRNRRQQRDSKVAEMVEVATV 437
            .|:..||:|.|||:.:......||.:.:|::  .:.:.:.||.||     ..:..|...|::..:
Human    68 GLQDGDRVLRINGVFVDKEEHMQVVDLVRKS--GNSVTLLVLDGD-----SYEKAVKTRVDLKEL 125

  Fly   438 SPTRKPHAAPVGTSLQVANTRKLG-------RKIEIMLKKGPNGLGFSVTTRDNPAGGHCPIYIK 495
            ..::|..    |.|..:.:....|       .::..::|:| ...|||:.|.....|    :|:.
Human   126 GQSQKEQ----GLSDNILSPVMNGGVQTWTQPRLCYLVKEG-GSYGFSLKTVQGKKG----VYMT 181

  Fly   496 NILPRGAAIEDGRLKPGDRLLEVDGTPMTGKTQTDVVAILRGMPAGATVR-IVVSRQQEL--AEQ 557
            :|.|:|.|:..|.| ..|.|:||:|..:...:..:||..::  .:|:.|. ::|.::.:.  .||
Human   182 DITPQGVAMRAGVL-ADDHLIEVNGENVEDASHEEVVEKVK--KSGSRVMFLLVDKETDKRHVEQ 243

  Fly   558 ADQPAEKSAGVAVAPSVAPPAVPAAAAPAPPIPVQKSSSARSLFTHQQQSQLNESQHFIDAGS-- 620
            ..|...::|.:.:.|.  .|.:         :.::|.|:....:......|..:....||:||
Human   244 KIQFKRETASLKLLPH--QPRI---------VEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPA 297

  Fly   621 -ESAASNDSLPPSSNSWHSREELTLHIPVHDTEKAG--LGVSVKGKTCSNL-------------- 668
             |:...|:.|..:.|. .|.|.|.....|....|.|  ..:.|..|...|:
Human   298 EEAGLKNNDLVVAVNG-ESVETLDHDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQS 361

  Fly   669 ----NASGSSA-----------------------------SSGSNGLMKH----DGDLGIFVKNV 696
                |.|...|                             :.|.||...|    .|..|.|:|.|
Human   362 QELPNGSVKEAPAPTPTSLEVSSPPDTTEEVDHKPKLCRLAKGENGYGFHLNAIRGLPGSFIKEV 426

  Fly   697 IHGGAASRDGRLRMNDQLLSVNGVSLRGQNNAEAMETLRRAMVNTPGKHPGTITLLV-------- 753
            ..||.|...| |...|.::.||||::..:...:.::     .:.:.||:   :||||
Human   427 QKGGPADLAG-LEDEDVIIEVNGVNVLDEPYEKVVD-----RIQSSGKN---VTLLVCGKKAYDY 482

  Fly   754 --GRKILRSASSSDILD-----------HSNSHSH-----SHSNSSGGSNSNGSGNNNNSSSNAS 800
              .:||...:|.:|.||           .||..||     :||.:|            :||||:.
Human   483 FQAKKIPIVSSLADPLDTPPDSKEGIVVESNHDSHMAKERAHSTAS------------HSSSNSE 535

  Fly   801 D 801
            |
Human   536 D 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873
		PDZ_signaling	341..412	CDD:238492	18/70 (26%)
		CRS1_YhbY	<390..>436	CDD:294440	9/45 (20%)
		PDZ_signaling	462..548	CDD:238492	23/86 (27%)
		PDZ_signaling	<686..753	CDD:238492	19/66 (29%)
PDZK1	XP_024303384.1	PDZ_signaling	27..107	CDD:238492	29/105 (28%)
		PDZ	152..232	CDD:214570	23/87 (26%)
		PDZ_signaling	261..340	CDD:238492	18/88 (20%)
		PDZ	395..475	CDD:214570	24/88 (27%)
		F1-ATPase_gamma	<457..>501	CDD:320933	12/51 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810