DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment baz and dysc

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	NP_001261810.1	Gene:	dysc / 39533	FlyBaseID:	FBgn0264006	Length:	1254	Species:	Drosophila melanogaster

Alignment Length:	1566	Identity:	295/1566 - (18%)
Similarity:	480/1566 - (30%)	Gaps:	569/1566 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 AHFDDPGPD--PGVPQGGGDGASGSSSVGTGSPDIFRDPTNTEAPTCPRDLSTPHIEVTSTTSGP 158
            |...|.||.  ...|.|....|:.::|.|.| |.:....:::..||                 |.
  Fly    25 AELCDLGPSRWSARPYGYNATAAAAASFGLG-PSMGGTQSSSSVPT-----------------GG 71

  Fly   159 MAGLGVGLMVRRSSDPNLLASLKAEGSNKRWSAAAPHYAGGDSPERLFLDKAGGQLSPQWEEDDD 223
            .|||                    .|.:.| |:.||   |..|.|...:..|.|.:||      .
  Fly    72 SAGL--------------------SGHHLR-SSGAP---GPSSFEAEDIGMAFGMISP------P 106

  Fly   224 PSHQLKEQLLHQQQPH----AANGGSSSGNHQPFAR--SGRLSMQFLGDGNGYKWMEAAEKLQNQ 282
            |.          ..|:    ||.|||..||.....|  .||..:.:...|..|..:|       :
  Fly   107 PG----------SGPYVGSSAAAGGSRVGNSTSSLRGAGGRSGLYYSPPGTSYTIVE-------R 154

  Fly   283 PPAQQTYQQGSHHAGHGQNGAYSSKSLPRESKRKEPLGQAYESIREKDGEMLLIINEYGSPLGLT 347
            |              |..:..::|..:|.:.......|.||.|               .||....
  Fly   155 P--------------HSPHYYFNSAGVPTKGGSLPGRGSAYLS---------------SSPASHM 190

  Fly   348 A------LPDKEHGGG-LLVQHVEPGSRAERGRLRRDDRILEINGIKLIGLTESQVQEQLRRALE 405
            |      ||......| .:.||.  .|...:.|....:::|     ::.|.|:|...........
  Fly   191 AAGTAGTLPTSTAASGRSMGQHA--SSNGNKKRPISPEQVL-----RMFGATQSSSVPTSSYHYS 248

  Fly   406 SSELRVRVLRGD---------------RNRRQQRDSKVAEMVEVATVSPTRKPHAAPVGTSLQVA 455
            :...|.|...|.               |:|.::||..|..:.|:.|             .::.::
  Fly   249 NGGTRDRDRTGRRSPASSPPSTTHQIYRDRERERDRSVPNIHELTT-------------RTVSMS 300

  Fly   456 NTRKLGRKIEIMLKKG-PNGLGFSVTTRDNPAGGHCPIYIKNILPRGAAIEDGRLKPGDRLLEVD 519
            ..:::.....|.:|.| .:|||               :||..|.....| |...|:|||.:|||:
  Fly   301 RDQQIDHGFGICVKGGKDSGLG---------------VYISRIEENSVA-ERAGLRPGDTILEVN 349

  Fly   520 GTPMTGKTQTDV----VAILRGMPAGATVRIVVSRQQELAEQADQPAEKSAGVAVAPSVAPPA-V 579
            |||.|.....:.    |.||:.           |||..:..:|......:|.:   ....||: .
  Fly   350 GTPFTSINHEEALKRCVQILKS-----------SRQISMTVRAPPTLNSTAPL---HGFGPPSRD 400

  Fly   580 PAAAAPAPPIPVQKSSSARSLFTHQQQSQLNESQHFIDAGSESAASNDSLPPSSNSWHSREELTL 644
            |..|:.|||:..|..::|                    |.:.:|||...||
  Fly   401 PMYASMAPPLHPQNQAAA--------------------AAAAAAASGAGLP-------------- 431

  Fly   645 HIPVHDTEKAGLGVSVKGKTCSNLNASGSSAS-------------------------SGSNGLMK 684
                            ..:|||.::..|..||                         ..|.|||.
  Fly   432 ----------------FRQTCSWMDRHGRPASPPMEYGGRRSERRDRIRRVELLIEPGQSLGLMI 480

  Fly   685 HDG---DLGIFVKNVIHGGAASRDGRLRMNDQLLSVNGVSLRGQNNAEAMETLR-----RAMVNT 741
            ..|   .|||||..|.....|.|.| |.:.|::|.|||.|.....:.||:..|:     ..::..
  Fly   481 RGGVEYGLGIFVTGVDKDSVADRSG-LMIGDEILEVNGQSFLDVTHDEAVGQLKYHKRMSLVIRD 544

  Fly   742 PGKHPGTITLLVGRKILRSASSSDILDHSNSHSHSHSNSSGGSNSNGSGNNNNSSSNASDNSGAT 806
            .||.|.:.|.:
  Fly   545 VGKVPHSCTSI------------------------------------------------------ 555

  Fly   807 VIYLSPEKREQRCNGGGGGGSAGNEMNRWSNPVLDRLTGGICSSNSAQPSSQQSHQQQPHPSQQQ 871
                                    ||..|               ::..|:..::.::....:..:
  Fly   556 ------------------------EMEPW---------------DAYSPTGTRARRKGQIATMVE 581

  Fly   872 QQQRRLPAAPVCSSAALRNESYYMA-------TNDNWSPAQMHLMTAHGNTALLIE-------DD 922
            ::.|.|  .|....|:|   |||:|       |.|.:....:.::..:....|:.|       :|
  Fly   582 EKARSL--LPRHHFASL---SYYIAEYSAKAMTIDAFVAVLLEMLDTYEKHTLVTEIRELVFPED 641

  Fly   923 AEPMSPTLPARPHD----GQHCNTSSANPSQNLAVGNQGPPINTVPG-TPSTSSNFDATYSSQLS 982
            .......:..|..|    .:|  ....:|:::|.|......|....| :||:.|....|.:
  Fly   642 RTRYDELVYRRERDPYSVDRH--RRKGDPARDLPVTADDLEIIAATGRSPSSDSGLGMTVT---- 700

  Fly   983 LETNSGVEHFSRDALG------------RRSISEKHHAALDARETGTYQRNKKLREERERERRIQ 1035
                   :.:.|.||.            .||....|:      :||:.|.:..|...::::::.|
  Fly   701 -------DIYKRPALQLPHRPMSAGPILHRSQPASHY------QTGSNQSSSSLSPPQQQQQQQQ 752

  Fly  1036 --------LTKSAVYGGSIES------------LTARIASANAQFS-GYKHAKTASSIE------ 1073
                    |......||::.|            |..|....|.|.. |....:|....|
  Fly   753 HYQPHHASLRHLGGIGGNVGSGRHHHHPLGPSQLKFRQTKDNQQQEYGCDEHRTRRGSETLLPEY 817

  Fly  1074 QRETQQQLAAAEAEARDQLGDLGPSLGMKKSSSLESLQTMVQEL---QMSDEPRGHQALRAPRGR 1135
            :.:.:|:||...:.:.|...:.|..||.|.....:|:|.:..|.   ..:::...|.....|..|
  Fly   818 EPDAEQELATKLSRSFDMKEEGGTLLGDKGVRRHQSMQRLSAEQNGGSTTEQTHEHNPNVVPDHR 882

  Fly  1136 GREDSLRAAVVSEPDASKPRKTWLLEDGD------------HEGGFASQRNGPFQSSLNDGKHGC 1188
            |   :|...|    ..:||.....:|.|.            ||.|.|.:..|.....|.....|.
  Fly   883 G---NLHITV----KKTKPILGIAIEGGANTKHPLPRIINIHENGAAFEAGGLEVGQLILEVDGT 940

  Fly  1189 KSSRAKKPSILRGIGHMFRFGKNRKDGVVPVDNYAVNISP-PTSVV--------STATSPQLQQQ 1244
            |........:.|.|...|...:..:...:.|:....|:.| ||:::        :...|..|::|
  Fly   941 KVEGLHHQEVARLIAECFANREKAEITFLVVEAKKSNLEPKPTALIFLEAXHLLALPASDPLERQ 1005

  Fly  1245 QQQQLQQ-----HQQQQQIPTAALAALERNGKPPAYQPPPPLP--APNGVGSNGIHQNDIFNHR- 1301
            :.:.|.:     .:..:.:||.......:|        |||||  ..|.:.|.......:.||:
  Fly  1006 KLEFLYEWGIDLTETPKPMPTPIPLTKAKN--------PPPLPHELHNNINSQYGSSAALSNHQP 1062

  Fly  1302 YQHYANYEDLHQQHQQH------------------------------QISGGDSTTSISETLSES 1336
            :||...:....||.|||                              |...|::|.:.::...|:
  Fly  1063 HQHTHPHPQQQQQQQQHSNTKTPNTNSNKTQGTPTTGTGAATTGSKQQQQPGNTTNTPTKASREA 1127

  Fly  1337 T--------------------------LECMRQQVIRQRIKVEAESRRHQHYHSQRSARSQDVS- 1374
            |                          |:..:||.:::..:.:....|.||:..||..|.::..
  Fly  1128 TPTREQHHQHATPTREHQQQTPTRQQQLQREQQQQLQREQQQQHHRDRQQHFREQREQREREYQH 1192

  Fly  1375 --------------MHSTSSGSQPGSLAQPQAQSNGVRPMSSYYEYETVQQQRVGSIKHSHSSSA 1425
                          .|......|.|....||.|        .:::|.:.||.:    ::|.|:|.
  Fly  1193 EHEHEQHHHHHHHREHHEQHQHQHGHQHHPQHQ--------HHHQYSSQQQHQ----RYSSSNSY 1245

  Fly  1426 TSSSSS 1431
            .|.::|
  Fly  1246 KSHNNS 1251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873	17/79 (22%)
		PDZ_signaling	341..412	CDD:238492	15/77 (19%)
		CRS1_YhbY	<390..>436	CDD:294440	12/60 (20%)
		PDZ_signaling	462..548	CDD:238492	25/90 (28%)
		PDZ_signaling	<686..753	CDD:238492	24/74 (32%)
dysc	NP_001261810.1	PDZ_signaling	294..380	CDD:238492	29/125 (23%)
		PDZ_signaling	466..543	CDD:238492	24/77 (31%)
		HN_L-whirlin_R2_like	573..653	CDD:259823	14/84 (17%)
		PDZ_signaling	886..971	CDD:238492	16/88 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810