DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment baz and Lnx1

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	NP_001101828.1	Gene:	Lnx1 / 360926	RGDID:	1308159	Length:	728	Species:	Rattus norvegicus

Alignment Length:	781	Identity:	183/781 - (23%)
Similarity:	278/781 - (35%)	Gaps:	237/781 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 YKVAAKQEGIPHGQLHKSYSLTLPKRPPSPSTYSCVKPDSWVTVTHLQTQSGILDPDDCVRDVAD 89
            |......:|..|      |.||..::..|..  .|  ||...::|     :..|.|:      ..
  Rat   126 YHFQTSCKGASH------YGLTKDRKRRSQD--GC--PDGCASLT-----ATTLSPE------VS 169

  Fly    90 DREQILAHFDDPGPDPGVPQGGGDGASGSSSVGTGSPDIFRDPTNTEAPTCPRDLSTPHIEVTST 154
            ....|....|:||.         |..:.:|||..|.|  ..:|::|....  |..:.|....|
  Rat   170 AAATISLMTDEPGL---------DNPAYTSSVEDGEP--VTNPSDTGRSN--RTRARPFERST-- 219

  Fly   155 TSGPMAGLGVGLMVRRSSDPNLLASLKAEGSNKRWSAAAPHY-AGGDSPE---------RLFLDK 209
                         :|..|...:..:|.|....|..||.|.|. .|.|:.|         |||...
  Rat   220 -------------MRSRSFKKINRALSALRRTKSGSAVANHADQGRDNSENDTVPEVFPRLFHLI 271

  Fly   210 AGGQLSPQWEEDDDPSHQLKEQLLHQQQPHAANGGSSSGNHQP--------------FARSGRL- 259
            ..|:::.......||:..|..:|:         |||.:    |              .||.|||
  Rat   272 PDGEITSIKINRVDPNESLSIRLV---------GGSET----PLVHIIIQHIYRDGVIARDGRLL 323

  Fly   260 ---------SMQFLGDGNGYKWMEAAEKLQNQPPAQQTYQQGSHHAGHGQNGAYSSKSLPRESK- 314
                     .|......:.|     |.:|..||  .|..:                .::.||.|
  Rat   324 PGDIILKVNGMDISNVPHNY-----AVRLLRQP--CQVLR----------------LTVLREQKF 365

  Fly   315 RKEPLGQAYESIREKDGEMLLIINEYGSP---LGLTALPDKEHGGGLLVQHVEPGSRAER-GRLR 375
            |......|.:|...:|....:|:|: .||   ||: .|..:....|:.:.:|..|..|:| |:|.
  Rat   366 RSRSNAPAPDSYGPRDDSFHVILNK-SSPEEQLGI-KLVRRVDEPGVFIFNVLNGGVADRHGQLE 428

  Fly   376 RDDRILEINGIKL-IGLTESQVQEQLRRALESSELRVRVLRGDRNRRQQRDSKVAEMVEVATVS- 438
            .:||:|.|||..| .|..||..     ..:::||.||.::..    ||.|........|...:|
  Rat   429 ENDRVLAINGHDLRFGSPESAA-----HLIQASERRVHLVVS----RQVRQPSPDIFQEAGCISN 484

  Fly   439 PTRKPHAAPVGTSLQVANTRKLGRKIEIMLKKGPN-GLGFSVTTRDNPAGG------HCPIYIKN 496
            ..:.|.:....||.:.|.|  ...|: :.::|.|| .||.:|      .||      ..|||:.:
  Rat   485 GQQSPVSGERSTSSKPAAT--CHEKV-VSVQKDPNESLGMTV------GGGASHREWDLPIYVIS 540

  Fly   497 ILPRGAAIEDGRLKPGDRLLEVDGTPMTGKTQTDVVAILRGMPAGATVRIVVSRQQELAEQADQP 561
            :.|.|....|||:|.||.||.|:|..:|..::|:.||||:..|:...::.:..::||..|...
  Rat   541 VEPGGVISRDGRIKTGDILLNVNGIELTEVSRTEAVAILKSTPSSVVLKALEVKEQETQEDCS-- 603

  Fly   562 AEKSAGVAVAPSVAPPAVPAAAAPAPPIPVQKSSSARSLFTHQQQSQLNESQHFIDAGSESAASN 626
                              |||.                           :|.|.:
  Rat   604 ------------------PAAL---------------------------DSNHNV---------- 613

  Fly   627 DSLPPS--SNSWHSREELTLHIPVHDTEKAGLGVSVKGKTCSNL----NASGSSASSGSNGLMKH 685
              .||.  |.||....||..::                ..|.::    |.:||.......|..::
  Rat   614 --TPPGDWSPSWVMWLELPQYL----------------YNCKDVILRRNTAGSLGFCIVGGYEEY 660

  Fly   686 DGDLGIFVKNVIHGGAASRDGRLRMNDQLLSVNGVSLRGQNN---AEAMETLRRAMVNTPGKHPG 747
            .|:...|:|:::.|..|..|||:|..|.||:|||.|..|..:   |..::.|:..:..|....||
  Rat   661 SGNQPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMMHACLARMLKELKGKITLTIASWPG 725

  Fly   748 T 748
            |
  Rat   726 T 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873	22/111 (20%)
		PDZ_signaling	341..412	CDD:238492	25/75 (33%)
		CRS1_YhbY	<390..>436	CDD:294440	11/45 (24%)
		PDZ_signaling	462..548	CDD:238492	31/92 (34%)
		PDZ_signaling	<686..753	CDD:238492	23/66 (35%)
Lnx1	NP_001101828.1	RING	45..81	CDD:214546
		DegQ	<260..364	CDD:223343	26/139 (19%)
		PDZ_signaling	276..360	CDD:238492	20/119 (17%)
		PDZ_signaling	384..464	CDD:238492	28/86 (33%)
		PDZ_signaling	506..589	CDD:238492	31/89 (35%)
		PDZ_signaling	637..721	CDD:238492	24/83 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810