DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment baz and Whrn

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_038965801.1	Gene:	Whrn / 313255	RGDID:	631330	Length:	969	Species:	Rattus norvegicus

Alignment Length:	1038	Identity:	229/1038 - (22%)
Similarity:	350/1038 - (33%)	Gaps:	354/1038 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 GLMVRRSSDPNLLASLKAEGSNKRWSAAAPHYAGGDSPERLFLDKAGGQLSPQWEEDDDPSHQLK 229
            ||.|..||..:|            .||||....||.:..|| |.....||           ||..
  Rat     7 GLSVSSSSTGSL------------GSAAAAAGGGGGAGLRL-LSANVRQL-----------HQAL 47

  Fly   230 EQLL----HQQQPHAANGGSSSGNHQPFARSGRL--------------------SMQFLGDGNGY 270
            ..||    .:|..|..|...:..|.....|:.|:                    |.|.|.|
  Rat    48 TALLSEPEREQFTHCLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSDQLLFD---- 108

  Fly   271 KWMEAAEKLQNQPPAQQTYQQGSHHAGHGQN-GAYSSKSLPRESKRKEPLGQAYESIREKDGEML 334
              ...||.|  ..||...|:|.:..|..|.. |.....|| |.:|..|.||   .|||.
  Rat   109 --QYTAEGL--YLPATTPYRQPAWAAPDGAGPGEVRLVSL-RRAKAHEGLG---FSIRG------ 159

  Fly   335 LIINEYGSPLGLTALPDKEHGGGLLVQHVEPGSRAERGRLRRDDRILEINGIKLIGLTESQVQEQ 399
                  ||          |||.|:.|..|||||.||:..||..|:||.:|...|..:|.::..:.
  Rat   160 ------GS----------EHGVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLARVTHAEAVKA 208

  Fly   400 LRRALESSELRVRVLRGDRNRRQQRDSKVAEMVEV---ATVSPTRKPHAAPVGTS---------- 451
            |:   .|.:|.:.|....|.......:.:...|:.   :|..|:..||.:.:...
  Rat   209 LK---GSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQGRSTSPPSSLPHGSTLRQHEDDRRSALHL 270

  Fly   452 LQVANTRKL------GRKIEIMLKKGPN-GLGFSVTTRDNPAGGHCPIYIKNILPRGAAIEDGRL 509
            ||..:.:|:      ||.:.:.::.|.. |||               |||..:.| |:..|...|
  Rat   271 LQSGDEKKVNLVLGDGRSLGLTIRGGAEYGLG---------------IYITGVDP-GSEAESSGL 319

  Fly   510 KPGDRLLEVDGTPMTGKTQTDVVAILR-GMPAGATVRIV--VSRQQELAEQADQPAEKSAGVAVA 571
            |.||::|||:|.........:.|.:|: ......||:.|  :...:...:|....|....|.::.
  Rat   320 KVGDQILEVNGRSFLSILHDEAVKLLKSSRHLILTVKDVGRLPHARTTVDQTKWIASSRIGESIT 384

  Fly   572 PSVAPPA--------------VPAAAAPAPPIPVQKSS-----------SARSLFTHQQQSQLNE 611
            .|...|.              .||.:      .|..||           .||.|.|.|:::.:
  Rat   385 NSAGFPGDLTEEGTNKPGFYKGPAGS------QVTLSSLGNQTRALLDDQARHLLTEQERATM-- 441

  Fly   612 SQHFIDAGSESAASNDSLPPS----SNSWHSR-------------------EELTLHIPVHDTEK 653
             .:::|.......|.::|..:    .|: |::                   :.|.|...: ::.|
  Rat   442 -MYYLDQYRGGTISVEALVMALFELLNT-HAKFSLLSEVRGIISPQDLDRFDHLVLRREI-ESMK 503

  Fly   654 A----GLGVSVKGKTCSNLNASGSSASSGSNGLMKHDGDLGIFVKNVIHGGAASRDGRLRMNDQL 714
            |    |.||   |.|.|.::.|.:.:|:||:|           ....:   :::|:..|.:.|.:
  Rat   504 ARQPPGPGV---GDTYSMVSYSDTGSSTGSHG-----------TSTTV---SSARERLLWLIDLM 551

  Fly   715 -----LSVNGVSLRGQNNA---EAMETLRRAMVNTPGKHP---------GTITLL-VGRKILRSA 761
                 |...|.:.:|..||   .:::.:|....:.||..|         |...|| ..||.:|.
  Rat   552 ENTLDLEGTGETTQGSTNALPDVSVDDVRSPSEDLPGIKPPPPPPPLAQGHDRLLGQTRKPVRE- 615

  Fly   762 SSSDILDHSNSHSHSHSNSSGGSNSNGSGNNNNSSSNASDNSGATVIYLSPEKREQRCNGGGGGG 826
                  |.:...|.:||.                           :::.:|..|
  Rat   616 ------DSAPLSSAAHSG---------------------------IVFSAPRNR----------- 636

  Fly   827 SAGNEMNRWSNPVLDRLTGGICSSNSAQPSSQQSHQQQPHPSQQQQQQRRLPAAPVCSSAALRNE 891
                     |.|.    ..||..:.:..|||                .|..|::|:.:|.:..|.
  Rat   637 ---------SPPP----PPGIAPTPTPGPSS----------------ARDSPSSPIYASISHANP 672

  Fly   892 SYYMATNDNWSPAQMHLMTAHGNTALLIEDDAEPMSPTLPARPH--------DGQHCNTSSANPS 948
            |       :..|...||       ||:.:....|. |.:.:.||        .|........:||
  Rat   673 S-------SRKPLDTHL-------ALVNQHPIGPF-PRVQSPPHLKSPPAEAPGAGAGLPPPSPS 722

  Fly   949 QNL-AVG-NQ------------GPPINTVPGTPSTSSNFDATYSSQLS-----LETNSGVE---- 990
            ::. ||| ||            .|.:|.|...|.|.:   |:..||||     |..:|||:
  Rat   723 EHADAVGANQHFVLVEVHRPDSEPDVNEVRALPQTRT---ASTLSQLSDSGQTLSEDSGVDAGET 784

  Fly   991 HFSRDALGRRSIS--EKHHAALDARETGTYQRNKKLREERERERRIQLTKS------AVYGGS 1045
            ..|....||::.:  .|:...|...|..|...||...........|::.||      |:.||:
  Rat   785 EASTSGRGRQTANTKNKNGKELPQTERTTEGANKPPGLLEPTSTLIRVRKSAATLGIAIEGGA 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873	5/8 (63%)
		PDZ_signaling	341..412	CDD:238492	25/70 (36%)
		CRS1_YhbY	<390..>436	CDD:294440	7/48 (15%)
		PDZ_signaling	462..548	CDD:238492	24/89 (27%)
		PDZ_signaling	<686..753	CDD:238492	15/84 (18%)
Whrn	XP_038965801.1	HN_L-whirlin_R1_like	38..113	CDD:259822	16/91 (18%)
		PDZ_signaling	139..216	CDD:238492	34/105 (32%)
		PDZ_signaling	276..356	CDD:238492	24/95 (25%)
		HN_L-whirlin_R2_like	418..498	CDD:259823	12/83 (14%)
		PDZ_signaling	<908..949	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810