DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment baz and PsGEF

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	NP_996333.4	Gene:	PsGEF / 31224	FlyBaseID:	FBgn0264598	Length:	2777	Species:	Drosophila melanogaster

Alignment Length:	1496	Identity:	296/1496 - (19%)
Similarity:	465/1496 - (31%)	Gaps:	441/1496 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PPKCPALANKLGGLFGWRHTYKVAAKQEGIPHGQLHKSYSLTLPKRPPSPSTYSCVKPDSWVT-- 67
            |.:|..|:|.:.|.....:...  :.:.|...|.:....|.|:.....|....|..:.::..|
  Fly  1470 PNRCCKLSNGIAGATEMANPKN--SNRTGTGTGSVTSMSSSTITGELSSKVVASSSRRETGDTES 1532

  Fly    68 -----VTHLQTQSGILDPDDCV-------RDVADDREQI----LAHFDDPGPDPGVPQGGGDGAS 116
                 :|...:||.....||.|       |...:....|    |.|.|.|.....:|.|     .
  Fly  1533 DVAQLITDEISQSQSEATDDSVGAMPNSSRSAGEGNPVITGSRLRHLDPPVSVSSLPNG-----H 1592

  Fly   117 GSSSVGTGSPDIFRDPTNTE--APTC---PRDLSTPHIE----VTSTT----SGPMAGLGVGLMV 168
            .|:.||.|||.....|..|.  |..|   ||..:...::    :|.|.    |.|..|.|.|...
  Fly  1593 CSAGVGGGSPKPLPPPRRTRVVAQMCQEPPRPKANQQVKAIVTITETARIMRSSPTKGSGSGSAT 1657

  Fly   169 RRSSDPNLLASLKAEGSNKRWSAAAPHYAGGDSPERLFLDKAGGQLSPQWEEDDDPSHQLKEQL- 232
            ...|         ..||..:::|.....    :||    |....||||     |...||..:.|
  Fly  1658 GTGS---------VGGSPAKYAACHCRC----TPE----DFTHAQLSP-----DKMEHQTCKLLE 1700

  Fly   233 --------LHQQQPHAANGGSSSGNHQPFARSGRLSMQFLGDGN--------GYKWMEAAEKLQN 281
                    |.|:|                 ...:||:..:|...        |   .|...|.:|
  Fly  1701 SPKQTTTTLEQKQ-----------------EDEQLSLMLIGLAQLAPAATLCG---QERIPKEEN 1745

  Fly   282 Q-------PPAQQTY--QQGSH---HAGHGQNGAYSSKSLPRESKRKEPLGQAYESIREK----- 329
            .       ||...:.  :..:|   ::|...||..:|.:....:..|:|.....|:|.|.
  Fly  1746 STPTIAVVPPTPDSVLTKTSTHVWDNSGCSSNGGGTSTTSTATTTTKQPRQAIIENIPEDSCDES 1810

  Fly   330 --DGE-----MLLIINEYGSPLGLTALPD-----------------KEHG-GGLLVQHVEPGSRA 369
              |.|     |...:..:|:...|..||.                 |.:| .|...|:.|....|
  Fly  1811 PLDEEPPYRPMSSALRRFGTMSSLEKLPSDDRMDEADELDDDLDSFKPNGHDGNSPQNEEDDEDA 1875

  Fly   370 --ERGRLRRDDRILEINGIKLIG----------LTESQVQEQLRRALESSELRVRVL----RGDR 418
              ||..::.|......:|:.:.|          ...:.|.:::....||.....:.|    .||.
  Fly  1876 DSERALVQNDLGASSSSGVIVNGEGLASGAWTNRAGAYVSDKMSFFEESRAFIDKYLGRWNAGDA 1940

  Fly   419 NRRQQR------DSKVAEMVEVATV------SPT---------------RKPHAAPVGTSLQVAN 456
            .::.|:      |.::.|....||.      :||               ...|::|..:|..:.:
  Fly  1941 QQQHQQGTASETDEQMDECTSGATSGEEVWGTPTSGGDNDDQDLQLINSENTHSSPTKSSTSLND 2005

  Fly   457 TRKLGRKIEIMLKKGPNGLGFSVTTRDNPAGGHCPIYIKNILPRGAAIEDGRLKPGDRLLEVDGT 521
            .......::.:|...|    .:.:|            |:.:|||   ....||:|   |.|.:..
  Fly  2006 DDDTELMMDELLMAPP----MTAST------------IRGLLPR---FYRRRLEP---LFEEETE 2048

  Fly   522 PMTGKTQTDVVAILRGMPAGATVRIVVSRQQELAEQADQPAEKSAGVAVAPSVAPPAVPAAAAPA 586
            ....|||.|...|.:|.                |.......|.|||.:......|||.|  ..|.
  Fly  2049 SDEEKTQQDSDDIKKGE----------------ATTNGHYLEDSAGSSSDSESVPPAPP--LVPR 2095

  Fly   587 PPIP-VQKSSSARSLFTHQQQSQLNESQHFIDAGSESAASNDSLPPSSNSWHSREELTLH-IPVH 649
            |.:| .::..||..    ||::...|.|..:.:..|....|    .::::...|..||.. :|..
  Fly  2096 PVVPDREEDPSAEG----QQENLAMEDQEDLHSSVERLLPN----LATSAMGPRPLLTTRLLPTT 2152

  Fly   650 DTEKAGLGVSVKGKTCSNLNASGSSASSGSNGLMKHDGDLGIFVKNVIHGGAASRDGRLRMNDQL 714
            ..:.....|.| ..:|..|.....|:..|.:                :.||:.............
  Fly  2153 AIDPQPPAVLV-ASSCEYLLDQRPSSVPGRD----------------LAGGSIGTTTMTSSRPTP 2200

  Fly   715 LSVNGVSLR--GQNNAEAMETLRRAMVNTPGKHPGTITLLVGRKILRSASSSDILDHSNSHSHSH 777
            ||....:..  |.|.....:|....|: ||.:.|                ||.|   |...|.|.
  Fly  2201 LSPAKAAATPIGMNATMTTKTTTTTMM-TPSRAP----------------SSTI---STISSASD 2245

  Fly   778 SNSSGGSNSN------------------------GSGNNN--NSSSNASDNSGATVIYLSPEKRE 816
            :.||||..|.                        |.....  ...|.|:.:||.:|..
  Fly  2246 TTSSGGRASGRPPRFVPPPPPPRRLLLTQTDLIAGQAKTELPRKKSGATADSGCSVAV------- 2303

  Fly   817 QRCNGGGGGGSAGNEMNRWSNPVLDRLTGGICSSNSAQPSSQQSHQQQPHPSQQQQQQRRL---- 877
                  |...||       |:|.   ..|.....::...||..|......||....:...|
  Fly  2304 ------GDAASA-------SDPT---AIGSRTMPSTPSTSSLASAVAPKRPSSTIIETCLLGAPR 2352

  Fly   878 PAAPVCSSAALRNESYYMATNDNWSPAQMHLMTAHGNT---ALLIEDDAEPMSPTLPARPHDGQH 939
            ||:...|:.|.|     ||.....||...|.....|.:   |:.....|.|.:||:| .||.|
  Fly  2353 PASATSSATASR-----MAKPIRQSPPTQHQSQPRGQSCPAAVPAPSTAAPDAPTVP-MPHAG-- 2409

  Fly   940 CNTS-------SAN----PSQNLAVGNQGPPINTVPGTPSTSSNFDATYSSQLSLETNSGVEHFS 993
            |..|       :.|    ..::|.....||.:.|:.|       .|.:...:|     :|.:..|
  Fly  2410 CGLSPRLEMRLALNHDILGDEDLICYEPGPDLTTILG-------HDLSTFHRL-----TGRDLLS 2462

  Fly   994 RDALGRRSISEKHHAALDARETGTYQRNKKLREERERERRIQLTKSAVYGGSIESLTARIASANA 1058
            |.|..|  :..|     :|..:.:.|||.|:.......|...|:..|: |||..:     ::.|.
  Fly  2463 RSATNR--VQPK-----EAVISYSQQRNSKMDTPTVNRRPRPLSAGAL-GGSTSN-----SNPNN 2514

  Fly  1059 QFSGYKHAK-------TASSIEQRETQQQLAAAEAEARDQLGD-----------LGPSLGMKKSS 1105
            ..|...|..       |.:.:|....||.:..|...:..::|.           ...:.|..|..
  Fly  2515 SRSSSSHGNSPLGGGLTRAGVEPVGQQQLVVQAGGGSAGRVGGGSGSAGGNSTACSSNRGGSKLG 2579

  Fly  1106 SLESLQTMVQELQMSDEPRGHQALRAPRGRGREDS-----------LRAAVVSEP-DASKPRKTW 1158
            .||.|....:...||....|        .|.||.:           :|:.:.||. |:|.|::
  Fly  2580 DLEILARREKIYSMSQSRSG--------CRVRETTSTTTLMAMATEMRSGMDSEKRDSSWPKR-- 2634

  Fly  1159 LLEDGDHEGGFASQRNGPFQSSLNDGKHGCKSSRAKKPSILRGIGHMFRFGKNRKDGVVPVDNYA 1223
                    ...|:.......|:..||.....::.....::..........|::::     :.|:.
  Fly  2635 --------AAAAASLTRTRSSTSMDGAGAISTTTTTTTTMTEEAFLETEVGRSKR-----LINFI 2686

  Fly  1224 VNISPPTSVVSTATSPQL------QQQQQQQLQ-----------QHQQQQQIPTAALAALERNGK 1271
            ...:...:..||:::|..      :|.|....|           |.|.|..:..|.::..:.|.|
  Fly  2687 KRRNSEITASSTSSTPNFSDGAIGEQPQPSHSQSSLLLQKLPPGQSQAQDSVEMAQMSPRKDNDK 2751

  Fly  1272 P 1272
            |
  Fly  2752 P 2752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873	35/142 (25%)
		PDZ_signaling	341..412	CDD:238492	18/100 (18%)
		CRS1_YhbY	<390..>436	CDD:294440	10/65 (15%)
		PDZ_signaling	462..548	CDD:238492	18/85 (21%)
		PDZ_signaling	<686..753	CDD:238492	11/68 (16%)
PsGEF	NP_996333.4	DUF4799	<102..209	CDD:292674
		C2	286..>381	CDD:278593
		PDZ_signaling	644..716	CDD:238492
		RhoGEF	831..1000	CDD:295373
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900