DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment baz and Ush1c

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_006229284.1	Gene:	Ush1c / 308596	RGDID:	1303329	Length:	910	Species:	Rattus norvegicus

Alignment Length:	957	Identity:	178/957 - (18%)
Similarity:	303/957 - (31%)	Gaps:	291/957 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   344 LGLTALPDKEHGGGLLVQHVEPGSRAERGRLRRDDRILEINGIKLIGLTESQVQEQLRRALESSE 408
            |||:.....|.|.||.:.|:..|.:|:...|:..|.|:.|||..:...|..:| ..|.|..::..
  Rat    98 LGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEV-INLIRTKKTVS 161

  Fly   409 LRVRVL--------RGDRNRRQQRDSKVAEM--VEVATVSPTRKPHAAPVGTSLQVANTRKLGRK 463
            ::||.:        ..:..:.|..|..|:|.  |.....||               .|.....:|
  Rat   162 IKVRHIGLIPVKSSPEEPLKWQYVDQFVSESGGVRGGLSSP---------------GNRTTKEKK 211

  Fly   464 IEIMLKKGPNGLGFSVTTRDNPAGGHCPIYIKNILPRGAAIEDGRLKPGDRLLEVDGTPMTGKTQ 528
            :.|.| .|..|||.|:::......|   |::.|:.|...:.|.| |:.||:::||:|...|....
  Rat   212 VFISL-VGSRGLGCSISSGPIQKPG---IFVSNVKPGSLSAEVG-LETGDQIVEVNGIDFTNLDH 271

  Fly   529 TDVVAILR-------GMPAGATVRIVVSRQQELAEQADQPAEKSAGVAVAPSVAPPAVPAAAAPA 586
            .:.|.:|:       .:.|||...:.::.::.|.|......::.
  Rat   272 KEAVNVLKSSRSLTISIVAGAGRELFMTDRERLEEARQHELQRQ--------------------- 315

  Fly   587 PPIPVQKSSSARSLFTHQQQSQLNESQHFIDAGSESAASNDSLPPS---------------SNSW 636
             .:.:||..:..|....|:|.:: |.|...:...::|..|:.....               ...|
  Rat   316 -ELLMQKRLAMESNKILQEQQEM-ERQRRKEIAQKAAEENERYRKEMEQISEEEEKFKKQWEEDW 378

  Fly   637 HSREELTL--------H-IPVHDTEKAGLGVSVKGKTCSNLNASGSSASSGSNGLMKHDGDLGIF 692
            .|:|:|.|        | :|:...:..|                         ...::||.....
  Rat   379 GSKEQLILPKTITAEVHPVPLRKPKSFG-------------------------WFYRYDGKFPTI 418

  Fly   693 VKNVIHGGAASRDG--RLRMNDQLLSVNGVSLRGQNNAEAMETLRRAMVNTPGKHPGTITLLVGR 755
            .|.......|..|.  .||.|.:.|.......:  ...|.:|..::..:|
  Rat   419 RKKAKEKKKAKYDSLQDLRKNKKELEFEQKLYK--EKEEMLEKEKQLKIN--------------- 466

  Fly   756 KILRSASSSDILDHSNSHSHSHSNSSGGSNSNGSGNNNNSSSNASDNSGATVIYLSPEKREQRCN 820
            ::.:..|.::..|...|....:                            .|..|...:.:|.
  Rat   467 RLAQEVSETEREDLEESEKTQY----------------------------WVERLCQTRLQQI-- 501

  Fly   821 GGGGGGSAGNEMNRWSN-------------PVLDRLTGGICSSNS-----------AQPSSQQSH 861
                 .||.||:...:.             |.|.|..|||....:           ..|.:..:.
  Rat   502 -----SSAENEITEMTTGPPPPPPSVSPLVPPLRRFAGGIHLHTTDLDDIPLDMFYYPPKTPSAL 561

  Fly   862 QQQPHPSQQQQQQRRLPAAPVCSSAALRNESYYMATNDNWSPAQMHLMTAHGNTALLIEDDAEPM 926
            ...|||....... ::||.||..|      |.:|:::.  ||...|       |...|.....|.
  Rat   562 PVMPHPPPSNPPS-KVPAPPVLPS------SDHMSSSS--SPWVQH-------TPPPIPIPPPPS 610

  Fly   927 SPT---LPARPHDGQHCNTSSANPSQNLAVGNQGPP-----INTVPGTPSTSSNFDATYS----- 978
            .||   .|.||...........:|   ...|:.|.|     .||..|.|::|...:.::.
  Rat   611 IPTQDLTPTRPLPSALEEVLGNHP---FRTGDPGHPATDWEANTHSGKPTSSPTPERSFPPAPKT 672

  Fly   979 -------------SQLSLETNSGVEH--FSRDALGRRSISEKHHAALDARETGTYQRNKKLRE-- 1026
                         |.:|.......||  ..|.|:....:.::....:...:|...|..:|..|
  Rat   673 FCPSPQPPRGPGVSTISKPVMVHQEHNFVYRPAVKSEVLPQEMLKRMVVYQTAFRQDFRKYEEGF 737

  Fly  1027 --------ERERERRIQLTKSAVYG-------GSIESLTARIASANAQFSGYKHAKTASSIEQRE 1076
                    |:...:.::|.:....|       |.::|...::. .:|.:.|....:....::..|
  Rat   738 DPYSMFSPEQIAGKDVRLLRIKKEGSLDLALEGGVDSPVGKVV-VSAVYEGGAAERHGGVVKGDE 801

  Fly  1077 ---------TQQQLAAAEA---EARDQLGD-------------LGPSLGMKKSSSLESLQTMVQE 1116
                     |...||.|||   :|.:|.||             ....|....||:.||.|.:.::
  Rat   802 IMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYDDELSSLPSSAAESPQPVRKQ 866

  Fly  1117 LQMSDEP---RGHQALRAPRGRGREDSLRAAVVSEPDASKPRKTWLL 1160
            |: :.||   .|......|..         .::...|.|:|..:|.|
  Rat   867 LE-AYEPVCRHGFFLQLEPTN---------LLLKSRDRSQPDPSWKL 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873
		PDZ_signaling	341..412	CDD:238492	20/67 (30%)
		CRS1_YhbY	<390..>436	CDD:294440	11/55 (20%)
		PDZ_signaling	462..548	CDD:238492	26/92 (28%)
		PDZ_signaling	<686..753	CDD:238492	12/68 (18%)
Ush1c	XP_006229284.1	harmonin_N	2..80	CDD:259819
		PDZ_signaling	85..165	CDD:238492	20/67 (30%)
		PDZ_signaling	209..289	CDD:238492	23/84 (27%)
		Cgr1	<316..>358	CDD:281823	9/42 (21%)
		PDZ_signaling	751..838	CDD:238492	17/87 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900