DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment baz and GRIP1

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_016874587.1	Gene:	GRIP1 / 23426	HGNCID:	18708	Length:	1188	Species:	Homo sapiens

Alignment Length:	1273	Identity:	254/1273 - (19%)
Similarity:	396/1273 - (31%)	Gaps:	401/1273 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   261 MQFLGDGNGYKWMEAAEKLQNQPPAQQTYQQGSHHAGHGQNGAYS--SKSLPRESKRKEPLGQAY 323
            ::||...|..:........|.:||                :||.:  .:|:|.|.|     |...
Human    85 LEFLAKSNSDESPYTKSASQTKPP----------------DGALAVRRQSIPEEFK-----GSTV 128

  Fly   324 ESIREKDGEMLLIINEYGSPLGLTALPDKEHGGGLLVQHVEPGSRAERG-RLRRDDRILEINGIK 387
            ..:.:|:          |:.||||.....:..|...|.::..|..|.|. :|...|.|..:|||.
Human   129 VELMKKE----------GTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGIN 183

  Fly   388 LIGLTESQVQEQLRRALESSELRVRVLRGDRNRRQQRDSKVAEMVEVATVSPTRKPHAAPVGTSL 452
            |......::...|:...|...|.|.                   .|:..||
Human   184 LAKFRHDEIISLLKNVGERVVLEVE-------------------YELPPVS-------------- 215

  Fly   453 QVANTRKLGRKIEIMLKKGPNGLGFSVTTRDNPAGGH------CPIYIKNILPRGAAIEDGRLKP 511
             |..:..:.|.:|:.|.|..|..||.:.     .|.|      .|:.|..:.|.|.|..:|.:||
Human   216 -VQGSSVIFRTVEVTLHKEGNTFGFVIR-----GGAHDDRNKSRPVVITCVRPGGPADREGTIKP 274

  Fly   512 GDRLLEVDGTPMTGKTQTDVVAILR--GMPAGATVRIVVSRQQELA--------EQADQPAE--- 563
            |||||.|||..:.|.|..:.::||:  |..|...:...||....:|        |.|..|..
Human   275 GDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASGPLLVEVAKTPGASLG 339

  Fly   564 -------------------KSAGVA--------------------------------------VA 571
                               |||.:|                                      |.
Human   340 VALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVK 404

  Fly   572 PSVAPPAVPAAAAPAPP-IPVQKS----------SSARSLFTHQQQSQLNESQHFIDA------- 618
            ..:.|......|...|. :.:|:|          |:..||.|:...:..:.....:.|
Human   405 LEILPHHQTRLALKGPDHVKIQRSDRQLTWDSWASNHSSLHTNHHYNTYHPDHCRVPALTFPKAP 469

  Fly   619 --GSESAASNDSLPPSSNSWHSREEL---TLHIPVHDTEKAGLGVSVKGKTCSNLNASGSSASS- 677
              .|..|..:.|..|:|.|.:|...|   ||...::.|...|..:..:.|. .:..:|.|.|||
Human   470 PPNSPPALVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKK-KDFKSSLSLASST 533

  Fly   678 -GSNGLMKH----------DGDLG--------IFVKNVIHG----------GAASRDGRLRMNDQ 713
             |..|.:.|          |...|        :|....:..          ..|.|.|.|::.|:
Human   534 VGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDR 598

  Fly   714 LLSVNGVSLRGQNNAEAMETLRRAMVNT-------------------------PGKH-------- 745
            ::::||:........||.:.||.:.:.:                         |.||
Human   599 VMAINGIPTEDSTFEEASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHNVELGITI 663

  Fly   746 -------PG----------------TITLLVGRKILRSASSSDILDHSNSHSHSHSNSSGGSNSN 787
                   ||                |.||.:|.|:|  |..:..||:.:................
Human   664 SSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLL--AIDNIRLDNCSMEDAVQILQQCEDLVK 726

  Fly   788 GSGNNNNSSSNASDNSGATVIYLSPEKREQRCNGGGGGGSAGNEMNRWSNP----VLDRLT-GGI 847
            .....:..:|:..::||| :||....||.        ||..|..::....|    ::..|| ||:
Human   727 LKIRKDEDNSDEQESSGA-IIYTVELKRY--------GGPLGITISGTEEPFDPIIISSLTKGGL 782

  Fly   848 CSSNSAQPSSQQSHQQQPHPSQQQQQQRRLPAAPVCSSAALRNESYYMATNDNWSPAQMHLMTAH 912
            .....|.....                 |:.|   .:|::|:.:....|         :||:...
Human   783 AERTGAIHIGD-----------------RILA---INSSSLKGKPLSEA---------IHLLQMA 818

  Fly   913 GNTALL-IEDDAEPMSPTLPARPHDGQHCN-----TSSANPSQNLAVGNQGPPINTVPGTPSTSS 971
            |.|..| |:...:..|.:.|.:.....|.:     ...::|:|.....:...| :|||...|...
Human   819 GETVTLKIKKQTDAQSASSPKKFPISSHLSDLGDVEEDSSPAQKPGKLSDMYP-STVPSVDSAVD 882

  Fly   972 NFDATYSSQLSLETNSGVEHFSRDALGRRSISEKHHAALDARETGTYQRNKKLREERERERRIQL 1036
            ::|.:     :::|:.|.:..|..|.|              ....||.    .|..::|.....:
Human   883 SWDGS-----AIDTSYGTQGTSFQASG--------------YNFNTYD----WRSPKQRGSLSPV 924

  Fly  1037 TK--SAVY---GGSIESLTARIASANAQFSGYKHAKTASSIEQRETQQQLAAAEAEARDQLGDLG 1096
            ||  |..|   |.|.|......|      ||:..|..::..||.|.....|..:.|...|.|.|.
Human   925 TKPRSQTYPDVGLSYEDWDRSTA------SGFAGAADSAETEQEENFWSQALEDLETCGQSGILR 983

  Fly  1097 PSLGMKKSSSLESLQTMVQELQMSDEPRGHQALRAPRGR-GREDSLRAAVVSEPDASK-PRKTWL 1159
            .......|.|..||              .|:| ..||.: ||:.|.:....|.|..|: .|...|
Human   984 ELEATIMSGSTMSL--------------NHEA-PTPRSQLGRQASFQERSSSRPHYSQTTRSNTL 1033

  Fly  1160 LEDGDHEGGFASQRNGPFQSSLNDGKHGCKSSRAKKPSILRGI-----GHMFRFGKNRKDGVVPV 1219
            ..|           .|....:|...|...|...:..|..|..:     ..|..||.:..||::..
Human  1034 PSD-----------VGRKSVTLRKMKQEIKEIMSPTPVELHKVTLYKDSDMEDFGFSVADGLLEK 1087

  Fly  1220 DNYAVNISP--PTSVVSTATSPQLQQQQQQQLQQHQQQQQIPTAALA------ALERNGKPPAYQ 1276
            ..|..||.|  |..:.......:|.|....:.:.......:|..|.:      .:.||
Human  1088 GVYVKNIRPAGPGDLGGLKPYDRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLVISRN------- 1145

  Fly  1277 PPPPLPAPNGVGSNGI-----HQNDIFNHRYQHYANYE 1309
               ||.:...:....:     .||..|..:..|..|.|
Human  1146 ---PLASQKSIDQQSLPGDWSEQNSAFFQQPSHGGNLE 1180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873
		PDZ_signaling	341..412	CDD:238492	20/71 (28%)
		CRS1_YhbY	<390..>436	CDD:294440	5/45 (11%)
		PDZ_signaling	462..548	CDD:238492	31/93 (33%)
		PDZ_signaling	<686..753	CDD:238492	22/140 (16%)
GRIP1	XP_016874587.1	PDZ_signaling	128..208	CDD:238492	21/89 (24%)
		PDZ_signaling	227..310	CDD:238492	30/87 (34%)
		PDZ_signaling	325..408	CDD:238492	8/82 (10%)
		PDZ_signaling	545..633	CDD:238492	14/87 (16%)
		PDZ_signaling	646..730	CDD:238492	14/85 (16%)
		PDZ_signaling	746..827	CDD:238492	23/117 (20%)
		PDZ_signaling	1062..1142	CDD:238492	15/79 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810