Protein Alignment baz and PDZD2

DIOPT Version :9

• Sequence 1: NP_001036283.1
• Gene: baz / 32703
• FlyBaseID: FBgn0000163
• Length: 1520
• Species: Drosophila melanogaster
• Sequence 2: XP_005248326.1
• Gene: PDZD2 / 23037
• HGNCID: 18486
• Length: 2873
• Species: Homo sapiens
• Alignment Length: 1660
• Identity: 349/1660 - (21%)
• Similarity: 553/1660 - (33%)
• Gaps: 512/1660 - (30%)

  Fly   100 DPGPDPGVPQGGGDGASGSSSVGTGSPDIFRDPTNTEAPTCPRDLSTPHIEVTSTTS-----GPM 159
            :||..|.:..|......|..:...|.  |.|.|.| :||  .....:...||:|..|     ||.
Human   196 EPGETPTLELGDRTAKKGKRTRKFGV--ISRPPAN-KAP--EESKGSAGCEVSSDPSTELENGPD 255

  Fly   160 AGLGVGLMVRRSSDPNLLASLKAEGSNKRWSAAAPHYAGG-------------DSPERLFLDK-- 209
            ..||.|.:.:..:.|:   |||        ..|.||....             |:|.....||
Human   256 PELGNGHVFQLENGPD---SLK--------EVAGPHLERSEVDRGTEHRIPKTDAPLTTSNDKRR 309

  Fly   210 --AGGQLSPQ-------------W-----EEDDDPSHQLKEQLLHQQQPHA------ANGGSSSG 248
              .||:...|             |     :|.|....|:......::.|||      ..||::.
Human   310 FSKGGKTDFQSSDCLAREEVGRIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAH- 373

  Fly   249 NHQPFARSGRLSMQFLGDG----NGYKWM-----EAAEKLQNQPPAQQTYQQGSHHAGHGQNGA- 303
                  |.||||   |||.    ||:..:     ||...|::.....|..      ....:|.|
Human   374 ------RDGRLS---LGDELLVINGHLLVGLSHEEAVAILRSATGMVQLV------VASKENSAE 423

  Fly   304 ----YSSKSLPRESKRKEPLGQAYES-IREKDGEMLLIINEYGSPLGLTALPDKEHGGGLLVQHV 363
                .:|||||..:...|.:....:: .:|.|||                   ::.|....||..
Human   424 DLLRLTSKSLPDLTSSVEDVSSWTDNEDQEADGE-------------------EDEGTSSSVQRA 469

  Fly   364 EPGS-------RAERGRLRRDDRILEINGIKL-------IGLTESQVQEQLRRALESSELRVRVL 414
            .||:       .||..:...:......|.|||       :...|| |:|.....:.:.:.|:|:|
Human   470 MPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSRLSGGVHRLES-VEEYNELMVRNGDPRIRML 533

  Fly   415 RGDRNRRQQRDSKVAEMVEVATVSPTRKPHAAPVGT----SLQVANTRKLGRKIEI----MLKKG 471
            ...|:.|:.   .:.::::.::.|  ::.|.....|    :.||.:..:|.|...|    :.|:.
Human   534 EVSRDGRKH---SLPQLLDSSSAS--QEYHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEK 593

  Fly   472 PNGLGFSVTTRDNPAGGHCPIYIKNILPRGAAIEDGRLKPGDRLLEVDGTPMTGKTQTDVVAILR 536
            ..|||||:....:...|...|::|.|.|.|:|.||||||.||.:|:|:|.|:.|.|..:.:...:
Human   594 GKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFK 658

  Fly   537 GMPAGATVRIVVSRQQELAEQADQPAEKSAGVAVAPSVAPPAVPAAAAPAPPIPVQKSSSARSLF 601
            .:.:|..|..|.::                  .|:||:.|.:.|
Human   659 QIRSGLFVLTVRTK------------------LVSPSLTPCSTP--------------------- 684

  Fly   602 THQQQSQLNESQHFIDAGSESAASNDSLPPSS---NSWHSREELTLHIPVHDTEKAGLGVSVKGK 663
            ||..:|   .|.:|..:|..||..:|....||   .:...::.:.:.:.::...:.|||:   |.
Human   685 THMSRS---ASPNFNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGI---GA 743

  Fly   664 TCSNLNASGSSASSGSNGLMKHDGDLGIFVKNVIHGGAASRDGRLRMNDQLLSVNGVSLRGQNNA 728
            .|..|..|..                ||::.::..|..|..:..|...||:|.||.|::|    .
Human   744 CCLALENSPP----------------GIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVR----H 788

  Fly   729 EAMETLRRAMVNTPGKHPGTITLLVGRKILRSASSSDILDHSNSHSHSHSNSSGGSNSNGSGNNN 793
            .|:..:...:...|   ||.:.|::||......|..: :|...:.| ::..|...::|.|.|...
Human   789 AALSKVHAILSKCP---PGPVRLVIGRHPNPKVSEQE-MDEVIARS-TYQESKEANSSPGLGTPL 848

  Fly   794 NSSSNASDNSGATVIYLSPEKREQRCNGGGGGGSAGNEMNRW-----SNPVLDRLTGGI------ 847
            .|.|.|..:|      |..|                :|::::     ..|:.|.:..|.
Human   849 KSPSLAKKDS------LISE----------------SELSQYFAHDVPGPLSDFMVAGSEDEDHP 891

  Fly   848 ---CSSN--SAQPSSQQSHQQQPHPSQQQ-------------------QQQRRLPAAPVCSSAAL 888
               ||::  .:.|.|..:|::...|....                   .:|..||.:|    .||
Human   892 GSGCSTSEEGSLPPSTSTHKEPGKPRANSLVTLGSHRASGLFHKQVTVARQASLPGSP----QAL 952

  Fly   889 RNE-------SYYMATNDNWSPAQMHLMTAHGNTALLIEDDAEPMSPTLPA--RPHDGQHCNTSS 944
            ||.       ..|.| ||           |........|.|...:...||.  ||.........|
Human   953 RNPLLRQRKVGCYDA-ND-----------ASDEEEFDREGDCISLPGALPGPIRPLSEDDPRRVS 1005

  Fly   945 ANPSQNLAVGNQ-------------GPPI--------NTVP---------------------GTP 967
            .:.|:.:.|.||             ..|:        .::|                     |:|
Human  1006 ISSSKGMDVHNQEERPRKTLVSKAISAPLLGSSVDLEESIPEGMVDAASYAANLTDSAEAPKGSP 1070

  Fly   968 -----------STSSNFDATYSSQLSLETNSGVEHFSR---DALGRR-----SISEK-HHAALDA 1012
                       |::...:.|..:.....||:|.....:   :.||.|     .:|.. ..:..:|
Human  1071 GSWWKKELSGSSSAPKLEYTVRTDTQSPTNTGSPSSPQQKSEGLGSRHRPVARVSPHCKRSEAEA 1135

  Fly  1013 RETG--TYQRNKKLREERERERRIQLTKSAVY------GGSIESLT-ARIASANAQFS-GYKHAK 1067
            :.:|  |.....:..:..:.:.|:|.|...|.      ||::|..: .::.:.:|..| ..:.|.
Human  1136 KPSGSQTVNLTGRANDPCDLDSRVQATSVKVTVAGFQPGGAVEKESLGKLTTGDACVSTSCELAS 1200

  Fly  1068 TASSIEQRETQQQLAAAEAE-------ARDQLGDLGPSLGMKKSSSLESLQTMVQELQMS----- 1120
            ..|.::.....:.|..|.:|       ..|...||..|.|.|.::..:..:|.|...|:|
Human  1201 ALSHLDASHLTENLPKAASELGQQPMTELDSSSDLISSPGKKGAAHPDPSKTSVDTGQVSRPENP 1265

  Fly  1121 DEP--------RGHQALRAPRGRGREDSLRAAVVSEPDASKPRKTWLLEDGDHEGGFASQRNGPF 1177
            .:|        :....:|.|.........:||  :.||.||.|.             ||:.:.|.
Human  1266 SQPASPRVTKCKARSPVRLPHEGSPSPGEKAA--APPDYSKTRS-------------ASETSTPH 1315

  Fly  1178 QSSLNDGKHGCKSSRAKKPSILRGIGHMFRFGKNRKDGVVPVDNYAVNISPPTSVVSTATSPQLQ 1242
            .:              ::.:.|||.|.... |......|:|.|       |.||          |
Human  1316 NT--------------RRVAALRGAGPGAE-GMTPAGAVLPGD-------PLTS----------Q 1348

  Fly  1243 QQQQQQLQQHQQQQQIPTAALAALERNG--KPPAYQPPPPLPAPNGVGSNG-------IHQNDIF 1298
            :|:|.....|.:          |||..|  .|.:.|.|..|...:.|.|..       :...|..
Human  1349 EQRQGAPGNHSK----------ALEMTGIHAPESSQEPSLLEGADSVSSRAPQASLSMLPSTDNT 1403

  Fly  1299 NHRYQHYANYEDLHQQHQQHQISGG---DSTTSISETLSESTLECMRQQVIRQRIKVEAESRRHQ 1360
            .....|.:.          |...||   ...|.|...:.|......|....:.......|.....
Human  1404 KEACGHVSG----------HCCPGGSRESPVTDIDSFIKELDASAARSPSSQTGDSGSQEGSAQG 1458

  Fly  1361 H----YHSQRSARSQDVSMHSTSS---------------GSQPGSL--AQPQAQ--------SNG 1396
            |    .....|.|::.|....|||               .|||..|  ..|...        ||.
Human  1459 HPPAGAGGGSSCRAEPVPGGQTSSPRRAWAAGAPAYPQWASQPSVLDSINPDKHFTVNKNFLSNY 1523

  Fly  1397 VRPMSSYYEYETVQQQRVGSIKHSHSS---SATSSSSSPINVPHW-KAAAMNGYSPASLNSSARS 1457
            .|..||::|..|.......|.:.|.||   .|..|||.|.::... :|:|.:|:||.....|...
Human  1524 SRNFSSFHEDSTSLSGLGDSTEPSLSSMYGDAEDSSSDPESLTEAPRASARDGWSPPRSRVSLHK 1588

  Fly  1458 RGPFVTQVTIREQ----SSGGI------PAHLLQQ 1482
            ..|..::   .||    |:.|.      ||||..|
Human  1589 EDPSESE---EEQIEICSTRGCPNPPSSPAHLPTQ 1620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873	21/78 (27%)
		PDZ_signaling	341..412	CDD:238492	16/84 (19%)
		CRS1_YhbY	<390..>436	CDD:294440	9/45 (20%)
		PDZ_signaling	462..548	CDD:238492	31/89 (35%)
		PDZ_signaling	<686..753	CDD:238492	17/66 (26%)
PDZD2	XP_005248326.1	PDZ_signaling	335..416	CDD:238492	22/96 (23%)
		PDZ_signaling	589..670	CDD:238492	29/80 (36%)
		PDZ_signaling	726..810	CDD:238492	24/109 (22%)
		PDZ_signaling	2623..2694	CDD:238492
		PDZ	2785..2867	CDD:214570

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810