DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment baz and LNX2

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	NP_699202.1	Gene:	LNX2 / 222484	HGNCID:	20421	Length:	690	Species:	Homo sapiens

Alignment Length:	816	Identity:	160/816 - (19%)
Similarity:	281/816 - (34%)	Gaps:	268/816 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 SPSTYSCVKPDSWVTVTHLQTQSGILDPDDCVRDVADDREQILAHFDDPGPDPGVPQGGGDGASG 117
            :|..:.|.: ..|....||......:| ||.|..:.  .:.:|...|.|
Human    20 NPLCFECGQ-QHWTRENHLYNYQNEVD-DDLVCHIC--LQPLLQPLDTP---------------- 64

  Fly   118 SSSVGTGSPDIFRDPTN--TEAPTCPRDLSTPHIEVTSTTSGPMAGLGVGLMVRRSSDPNLL--- 177
                 .|....::...|  .|...||.|....|.::...:|         ::|.:..|..|:
Human    65 -----CGHTFCYKCLRNFLQEKDFCPLDRKRLHFKLCKKSS---------ILVHKLLDKLLVLCP 115

  Fly   178 -----------ASLKAEGSNKRWSAAAPHYAGGDSPERLFLDK--------------------AG 211
                       ..|:|...|:         ..|.|..|:.|::                    ..
Human   116 FSSVCKDVMQRCDLEAHLKNR---------CPGASHRRVALERRKTSRTQAEIENENGPTLLDPA 171

  Fly   212 GQLSPQ----------------------WEED---DDPSHQ-------LKEQL-----------L 233
            |.|||:                      |.|:   |:|:.:       .::.|           :
Human   172 GTLSPEADCLGTGAVPVERHLTSASLSTWSEEPGLDNPAFEESAGADTTQQPLSLPEGEITTIEI 236

  Fly   234 HQQQPHAANGGS-SSGNHQP--------------FARSGRLSMQFLGDG----NGYKWMEA---- 275
            |:..|:...|.| ..||..|              .||.|||   ..||.    |.|.....
Human   237 HRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRL---LAGDQILQVNNYNISNVSHNY 298

  Fly   276 AEKLQNQP--PAQQTYQQGSHHAGHGQNGAYSSKSLPRESKRKEPLGQAYE-SIREKDGEMLLII 337
            |..:.:||  ....|..:.........|  :|..:.|||        :.:: ::.::|.
Human   299 ARAVLSQPCNTLHLTVLRERRFGNRAHN--HSDSNSPRE--------EIFQVALHKRDS------ 347

  Fly   338 NEYGSPLGLTALPDKEHGGGLLVQHVEPGSRAERGRLRRDDRILEINGIKL-IGLTESQVQEQLR 401
               |..||:..:...:..|..::..:|.|..|:.|||..:||:|.|||..| .|..|...|
Human   348 ---GEQLGIKLVRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQ---- 405

  Fly   402 RALESSELRVRVLRGDRNRRQQRDSKVAEMVEVATVSPTRKPHAAPVGTSLQVANTRKLGRKI-- 464
             .:::|..||.:......:.|..::    :.|....|.:.:.|..|...| :.::.:.|.:.:
Human   406 -IIQASGERVNLTIARPGKPQPGNT----IREAGNHSSSSQHHTPPPYYS-RPSSHKDLTQCVTC 464

  Fly   465 ---EIMLKKGPN-GLGFSVTTRDNPAGGHCPIYIKNILPRGAAIEDGRLKPGDRLLEVDGTPMTG 525
               .|.:||.|: .||.:|........|..||::.::.|.|....|||:|.||.||.::|..:|.
Human   465 QEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTN 529

  Fly   526 KTQTDVVAILRGMPAGATVRIVVSRQQELAEQADQPAEKSAGVAVAPSVAPPAVPAAAAPAPPIP 590
            .:.::.||:|:...|...|.: .:.:.::.|:|.|.||
Human   530 LSHSEAVAMLKASAASPAVAL-KALEVQIVEEATQNAE--------------------------- 566

  Fly   591 VQKSSSARSLFTHQQQSQLNESQHFIDAGSESAASNDSLPPSSNSWHSREELTLHIPVHDTEKAG 655
                         :|.|..:|:::  ||         |..||...|
Human   567 -------------EQPSTFSENEY--DA---------SWSPSWVMW------------------- 588

  Fly   656 LGVSVKGKTCSNL----NASGSSASSGSNGLMKHDGDLGIFVKNVIHGGAASRDGRLRMNDQLLS 716
            ||:.....:|.::    :..||...|...|..::..:...|:|.::.|..|..||||:..|.:::
Human   589 LGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVA 653

  Fly   717 VNGVSLRGQNNAEAMETLRRAMVNTPGKHPGTITLL 752
            |||:|..|.:::..:..|:..      ::..|:|::
Human   654 VNGLSTVGMSHSALVPMLKEQ------RNKVTLTVI 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873	19/113 (17%)
		PDZ_signaling	341..412	CDD:238492	22/71 (31%)
		CRS1_YhbY	<390..>436	CDD:294440	8/45 (18%)
		PDZ_signaling	462..548	CDD:238492	27/91 (30%)
		PDZ_signaling	<686..753	CDD:238492	17/67 (25%)
LNX2	NP_699202.1	mRING-HC-C3HC3D_LNX2	45..89	CDD:319694	13/67 (19%)
		modified RING-HC finger (C3HC3D-type)	50..87	CDD:319694	8/59 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..224		4/25 (16%)
		NPXY motif	208..211		1/2 (50%)
		PDZ	230..316	CDD:214570	20/88 (23%)
		PDZ	336..422	CDD:214570	24/99 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	418..455		6/41 (15%)
		PDZ_signaling	466..542	CDD:238492	25/75 (33%)
		PDZ_signaling	599..683	CDD:238492	21/89 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810