DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment baz and magi-1

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	NP_001255577.1	Gene:	magi-1 / 178107	WormBaseID:	WBGene00010444	Length:	1054	Species:	Caenorhabditis elegans

Alignment Length:	731	Identity:	168/731 - (22%)
Similarity:	253/731 - (34%)	Gaps:	213/731 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 WSAAAPHYAGGDSPERLFLDKAGG--------QLSPQWEEDDDPSH--------QLKEQLLHQQQ 237
            |..|  :...||   :.|:|...|        :|.|.||:.||.::        ..|.|   .::
Worm   266 WETA--YTENGD---KYFIDHNTGTTTWDDPRELPPGWEQVDDQNYGTFYVDHINRKTQ---YER 322

  Fly   238 PHAANGGS-------------SSGNHQ-----PFARSGRLSMQFLGDGNGYKWMEAAEKLQNQPP 284
            |:...|.|             ||.||.     ....||.|........:|:.......:....||
Worm   323 PYGFGGSSATIDQPVKYGTLPSSTNHNHNNIYSHYNSGTLKSSSSPRDSGFDSSPTRYRKFGDPP 387

  Fly   285 AQQTYQQG-SHHAGHGQNGAYSSKSLPRESK---RKEPLGQAYESIREKDGEMLLIINEYGSPLG 345
            ...|.... .||          ||...|.|.   ..:|.....|.|..|       |.:....||
Worm   388 ETATSSADYDHH----------SKMFSRSSNPLFTTDPARLGGELISTK-------IVKGAKGLG 435

  Fly   346 LTAL-PDKEHGGGLLVQ---HVEPGSRAERGRLRRDDRILEINGIKLIGLTESQVQEQLRRALES 406
            .|.: .|....|...:|   .:..|..|..|.||..|.::.:||..|:|.|:.:..:.......:
Worm   436 FTLIGNDSSSRGDEFIQVKSVLSGGPAAANGVLRSGDILVRVNGRLLLGATQKEACDVFVAIPVN 500

  Fly   407 SELRVRVLRGDRNRRQQRDSKVAEMVEVATVSPTRKPHAAPVGTSLQVANTRKLGRKIEIMLKKG 471
            ..:.::|.||           ....::.|....|...:||        |.:|.|.   ||.:.||
Worm   501 EAVDIQVCRG-----------YELFIDPANRIVTENVYAA--------AKSRDLH---EIDIFKG 543

  Fly   472 PNGLGFSVTTRDNPAGGHCPIYIKNIL-PRGAAIEDGRLKPGDRLLEVDGTPMTGKTQTDVVAIL 535
            ..|.||::.  ||..|..    ||.|| |.    :...|..||.::|:||..:.....|.:|.:|
Worm   544 SEGFGFTIA--DNLNGQR----IKKILFPS----QCPNLMEGDTIVELDGRNVRPIPHTQLVDML 598

  Fly   536 RGMPAGATVRIVVSRQQELAEQADQPAEKSAGVAVAPSVAPPAVPAAAAPAPPIPVQKSSSARSL 600
            |..|.|...::||.|        ..|..:|...:.|.....|......: |.|:||:..:.|
Worm   599 RERPIGYRGKLVVKR--------GSPKTRSRTPSAAFRYGEPQTNMMDS-AAPLPVRSKTPA--- 651

  Fly   601 FTHQQQSQLNESQHFIDA------------GSESAASNDSLPPSSNSWHSREELTL------HIP 647
              .:|.|:..|.|:..:.            |..||.....:.|||.        ||      :||
Worm   652 --ERQTSRTEEDQNVRNTLQRQPAVTSEWEGMSSAIPASRMRPSST--------TLGFATPNYIP 706

  Fly   648 VHD--------------TEKAGLGVSVKGKTCSNLNASGSSASSGSNGLMKHDGDLGIFVKNVIH 698
            :..              .:..|.|..:.|...|....|                     |..::.
Worm   707 LSQYNQKPSDLITVSLIRKPVGFGFRLLGGVESKTPLS---------------------VGQIVI 750

  Fly   699 GGAASRDGRLRMNDQLLSVNGVSLRGQNNAEAMETLRRAMVNTPGKHPGTITLLVGRK------- 756
            ||||..||||:..|:::.::|.::.|.:::||:..|..|..|   ||   :.|:|.|.
Worm   751 GGAAEEDGRLQEGDEIVEIDGHNVEGASHSEAVVLLEAAAQN---KH---VKLIVRRPSRTDPAR 809

  Fly   757 --ILRSASSS---DILDHSNSHSHSHSNSSGGSNSNGSGNNNNSSSNASDNSGATVIYLSPEKRE 816
              .|.||..|   |:|.|.|             .::|.|....||.:   .:|:||..:.|....
Worm   810 RGSLNSAGPSGSYDVLLHRN-------------ENDGFGFVLMSSQH---KNGSTVGQIQPGSPA 858

  Fly   817 QRCNGGGGGGSAGNEM 832
            .||    |..|.|:.:
Worm   859 ARC----GRLSVGDRV 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873
		PDZ_signaling	341..412	CDD:238492	17/74 (23%)
		CRS1_YhbY	<390..>436	CDD:294440	5/45 (11%)
		PDZ_signaling	462..548	CDD:238492	27/86 (31%)
		PDZ_signaling	<686..753	CDD:238492	20/66 (30%)
magi-1	NP_001255577.1	NK	180..>244	CDD:302627
		WW	263..293	CDD:238122	7/31 (23%)
		WW	294..323	CDD:278809	8/31 (26%)
		PDZ	421..510	CDD:214570	22/95 (23%)
		PDZ_signaling	535..600	CDD:238492	25/77 (32%)
		PDZ_signaling	717..800	CDD:238492	25/109 (23%)
		PDZ_signaling	822..902	CDD:238492	17/69 (25%)
		PDZ_signaling	968..1049	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910