DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment baz and Mpdz

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	NP_001292213.1	Gene:	Mpdz / 17475	MGIID:	1343489	Length:	2069	Species:	Mus musculus

Alignment Length:	1312	Identity:	280/1312 - (21%)
Similarity:	437/1312 - (33%)	Gaps:	400/1312 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 SSSGNHQPFARSGRLSM--QFLG-DG---NGYKWMEAAEKLQNQPPAQQTYQQGSHHAGHGQNGA 303
            ||:..|     .||:.:  |.:. ||   .|:...:|.|.|::   ..||.:......|..|...
Mouse   414 SSAVEH-----DGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRH---TGQTVRLTLMRKGASQEAE 470

  Fly   304 YSSK-------SLPRESKRKEPLGQAYESIREKDGEMLLIINEYGSPL---GLTALPDKEHGGGL 358
            .:|:       .||.|:..|:.     ||:..|....:|.|.|.|.||   .|....|.:....|
Mouse   471 LTSRGDTAKDVDLPAENCEKDE-----ESLSLKRNTSILPIEEEGFPLLSAELEEAEDVQQEAAL 530

  Fly   359 L--------------VQHVE--------------------------PGSRAERGRLRRDDRILEI 383
            |              |.||.                          .|.....|:|...|.:||:
Mouse   531 LTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEV 595

  Fly   384 NGIKLIGLTESQVQEQLRRALESSELRVRVLRGDRNRRQQRDSKVAEM--VEVATVSPTRKPH-- 444
            |||.|:|.....|...|:      ||.:.|.. ...||......::||  :::..:..|.|||
Mouse   596 NGINLLGENHQDVVNILK------ELPIDVTM-VCCRRTVPPIALSEMDSLDINDLELTEKPHID 653

  Fly   445 -AAPVGTS------LQVANTRKLGRKIE------------IMLKKGPNGLGFSVTTRDNPAG-GH 489
             ...:|:|      |.:::..:...:|:            |.|:||..|||||:....:|.. .:
Mouse   654 LGEFIGSSETEDPMLAMSDVDQNAEEIQTPLAMWEAGGQSIELEKGSRGLGFSILDYQDPIDPAN 718

  Fly   490 CPIYIKNILPRGAAIEDGRLKPGDRLLEVDGTPMTGKTQTDVVAILRGMPAGATVRIVVS----- 549
            ..|.|::::|.|.|.:||||.|||||:.|:...:...|..:.|..|:|.|:| .|||.|:
Mouse   719 TVIVIRSLVPGGIAEKDGRLFPGDRLMFVNDINLENSTLEEAVEALKGAPSG-MVRIGVAKPLPL 782

  Fly   550 ---------------------RQQELAEQA---------DQP-AEKSAGVAVAPSVAP------- 576
                                 ::..|:::|         |.| ||..|........:|
Mouse   783 SPEEGYVSAKEDAFLCSPHACKESGLSDKALFRADLALIDTPDAESIAESRFESQFSPDNDSVYS 847

  Fly   577 --------------------PAVPAAAAPAPPIPVQKSS--------SARSLFTHQQQSQLNESQ 613
                                |::|:    :||..|..||        |...|:|    ..|.:.|
Mouse   848 TQASIFSLHDGTCSDGMNYGPSLPS----SPPKDVTSSSEVVLGLHLSLEELYT----QNLLQRQ 904

  Fly   614 HFIDAGSESAASNDSLP-PSSN----------------------SW-HSR-------EELTLHIP 647
            |   |||   ...|..| |:|.                      :| ||:       .||...:|
Mouse   905 H---AGS---PPTDMRPAPTSGFPISDYTTTNAVEQKYECANPVAWPHSQLPSSLSTSELAPALP 963

  Fly   648 V----HDTEKAGLGVSVKGKTCSNLN----------ASGSSASSGSNGLMKHDGDLGIFVKNVIH 698
            .    :.|:::.|....:.....:::          |.||| |.|.......|| ||:.|:::||
Mouse   964 AVAQKYLTDQSSLASDAESVNLQSMSQEAFERTVTIAKGSS-SLGMTVSANKDG-LGVIVRSIIH 1026

  Fly   699 GGAASRDGRLRMNDQLLSVNGVSLRGQNNAEAMETLRRAMVNTPGKHPGTITLLVGRKILRSASS 763
            |||.|||||:.:.|.:||:|..|.....||:|...|||        |.     |:|..|..||:.
Mouse  1027 GGAISRDGRIAVGDCILSINEESTISLTNAQARAMLRR--------HS-----LIGPDIKFSAAP 1078

  Fly   764 SD-----------ILDHSNSHSHSHSNSSGGSNSNGSGNNNNSSSNASDNSGATVIYLSPEKREQ 817
            :|           ..:|......|....:||.         .:....|..:|..:..| ||:.|
Mouse  1079 ADDRAPFYVITYVPAEHLEEFRVSFGQQAGGI---------MALDIFSSYTGRDIPEL-PEREE- 1132

  Fly   818 RCNGGGGGGSAGNEMN----RWSNP-----------------VLDRLTGGICSSNSAQPSSQQSH 861
                  |.|......|    .||.|                 |..|..|...|:..........|
Mouse  1133 ------GEGEESELQNAAYSSWSQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKH 1191

  Fly   862 QQQPHPSQQQQQQRRLPAAPVCSSAALRNESYYMATNDNWSPAQMHLMTAHGNTALLIEDDA--E 924
            ..:..|:.:....:............||:.|:..|         :..:...||..:.:....  .
Mouse  1192 VLEDSPAGKNGTLKPGDRIIEVDGMDLRDASHEQA---------VEAIRKAGNPVVFMVQSIINR 1247

  Fly   925 PMSPTLPARPH---------------DGQHCNTSSANPSQNLAVGNQGPPINTVPGTPSTSSNF- 973
            |....||:.||               |.....|..| |||:.:...:....|..|.:||..|..
Mouse  1248 PRKSPLPSLPHSLYPKYSFSSTNPFADSLQLTTDQA-PSQSESETEKPALCNVPPSSPSVFSEMG 1311

  Fly   974 -DATYSSQLSLETNSGVEHFSRDALGR--RSISEK--------HHAALDARETGTYQRNKKLREE 1027
             |....|..::..:...|    |..|.  ::|.|:        |...|:..::|.   ...|...
Mouse  1312 SDCAQPSATAVSEDEDKE----DEFGYSWKNIQERYGSLTGQLHVIELEKGQSGL---GLSLAGN 1369

  Fly  1028 RERERR------IQLTKSAVYGGSIESLTARIASANAQ-FSGYKHAKTASSIEQRETQQQLA-AA 1084
            ::|.|.      |..|.:|...|.:: :...:...|.| ..|..|...:|.|:...::.::. ..
Mouse  1370 KDRTRMSVFIVGIDPTGAAGRDGRLQ-IADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIR 1433

  Fly  1085 EAEARDQLGDLGPSLGMKKSSSLESLQTMVQELQMSDEPRGHQALRAPRGRGREDSLRAAVVSEP 1149
            .|:|.:|:. :.|.:.....||            .||.|:..:.          :.......|..
Mouse  1434 NADAVNQMA-VCPGIAADSPSS------------TSDSPQNKEV----------EPCSTTSASAA 1475

  Fly  1150 DASKPRKTWLLEDGDHEGGFA------SQRNGPFQSSLNDGKHGCKSSRAKKPSILRGIGHMFRF 1208
            |.|.....:.||....:||..      ...||....||.:.....|..|. ||.
Mouse  1476 DLSSLTDVYQLELPKDQGGLGIAICEEDTINGVMIESLTEHGGAAKDGRL-KPG----------- 1528

  Fly  1209 GKNRKDGVVPVDNYAVNISPPTSVVSTATSPQLQQQQQQQLQQHQQQQQIPTAALAALERNGKPP 1273
                 |.::.||:..|...|....:|...:    .:...:|....:....|....:|:..:|:..
Mouse  1529 -----DHILAVDDEVVAGCPVEKFISLLKT----AKATVKLTVRAENPACPAVPSSAVTVSGERK 1584

  Fly  1274 AYQPPPPLPAPN 1285
            .....|.:|||:
Mouse  1585 DNSQTPAVPAPD 1596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873
		PDZ_signaling	341..412	CDD:238492	25/113 (22%)
		CRS1_YhbY	<390..>436	CDD:294440	10/47 (21%)
		PDZ_signaling	462..548	CDD:238492	35/98 (36%)
		PDZ_signaling	<686..753	CDD:238492	27/66 (41%)
Mpdz	NP_001292213.1	L27_2	6..63	CDD:117611
		PDZ_signaling	140..222	CDD:238492
		PDZ_signaling	256..335	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..372
		PDZ	375..464	CDD:214570	14/57 (25%)
		PDZ_signaling	553..622	CDD:238492	16/75 (21%)
		PDZ_signaling	694..777	CDD:238492	34/83 (41%)
		PDZ_signaling	994..1064	CDD:238492	30/71 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1125..1144		7/26 (27%)
		PDZ_signaling	1151..1242	CDD:238492	13/99 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1278..1313		10/35 (29%)
		PDZ	1349..1434	CDD:214570	16/88 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1449..1473		5/45 (11%)
		PDZ_signaling	1483..1563	CDD:238492	19/100 (19%)
		MPDZ_u10	1564..1625	CDD:293272	7/33 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1571..1611		6/26 (23%)
		PDZ	1626..1710	CDD:214570
		PDZ_signaling	1722..1802	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1809..1848
		PDZ_signaling	1859..1944	CDD:238492
		PDZ_signaling	1985..2068	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810