DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment baz and Grid2ip

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	NP_001152793.1	Gene:	Grid2ip / 170935	MGIID:	2176213	Length:	1203	Species:	Mus musculus

Alignment Length:	1239	Identity:	239/1239 - (19%)
Similarity:	380/1239 - (30%)	Gaps:	477/1239 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   339 EYGSPLGLTALPDKEHGGGLLVQHVEPGSRAERGRLRRDDRILEINGIKLIGLTESQV------- 396
            ::|..||        ..|...|..|..||.|..|.||..|:|||:.|:.:.||:..::
Mouse    11 DFGFQLG--------GSGPCFVIEVAEGSSAHAGGLRPGDQILEVEGLAVGGLSRERIVRLARRC 67

  Fly   397 ----------------------------------------------------QEQLRRALESS-- 407
                                                                :|:.|:|.|.|
Mouse    68 PRVPPSLGVLPGPEGGPTALTAAWLTRRFGRSLPLSRELLRLAGGPRPDAVHRERRRKAQEFSCQ 132

  Fly   408 -----------------------------EL---------------------------------- 409
                                         ||
Mouse   133 VDDILGDRLTAKEQVFTALKQFAAEQRVDELVWTLTLVLPSEAQGPVLDNLRIFIPKKHRARFDE 197

  Fly   410 -----------RVRVLRGDRNRRQQRDSKVAEMVEVAT---VSPTRKPHAAP--VGTSLQVANTR 458
                       |.|..:|.:..|:.|..:..|.:.|:|   .:| |:|...|  ..|||....|.
Mouse   198 VVSQGLLGKLCRARRAQGAQRLRRSRSEERPERLLVSTRASAAP-RRPDEPPPRKATSLLGGRTG 261

  Fly   459 KLGRKIEIMLKKGPNGLGFSVTTRDNPAGGHCPIYIKNILPRGAAIEDGRLKPGDRLLEVDGTPM 523
            ..|.:..:.:.||....||::.       ||.|::|:::|| |:..|:..||.|||:|.::|..|
Mouse   262 PGGPRRTVRVYKGNKSFGFTLR-------GHGPVWIESVLP-GSPAENASLKSGDRILFLNGLDM 318

  Fly   524 TGKTQTDVVAILRGMPAGATVRIVVSRQ----QELAEQADQPAEKSAGVA------VAPS----- 573
            ...:...||::|:|  :||...:||...    ...::..|.|...||..:      :.||
Mouse   319 RNCSHDKVVSMLQG--SGAMPTLVVEEGPVPFASDSDSLDSPTRASALTSLQWVADILPSSIRVQ 381

  Fly   574 -----------VAPP------------------------AVPAAAAPAPPIPVQKSSSARSLFTH 603
                       :.||                        ..|....||..:..|   ....|.|:
Mouse   382 GRTFSQQLDHLLTPPERYGVCRALERFFQHRNIDTLIVDVYPVLDTPAKQVLWQ---FLYQLLTY 443

  Fly   604 QQQSQLNES-QHFI--DAGSESAASNDSLPPSSNSWHSREELTLHIPVHDTEKAGLGVSVKGKTC 665
            ::|....|. ..|:  .|.:|..:|.|..|.|:..           |..:.:..
Mouse   444 EEQELCQEKIACFLGYTAMTEPESSLDLEPESTPE-----------PTPEPQPR----------- 486

  Fly   666 SNLNASG----SSASSG-SNGLMKHDGDLGIFVKNVIHGGAASRDGRL---RMNDQLLSVNGVSL 722
            |:|.||.    |..|.| ...|....||.......:|.|...:.||..   ..|.:::|.....|
Mouse   487 SSLRASSMCRRSLRSQGLETSLSCGPGDCPEMPLPLIPGERQAGDGTSLPETPNPKMMSAVYAEL 551

  Fly   723 RGQNNAE---AMETLRRAMVNTPGKHPGTITLLVGRKILRSAS-------------------SSD 765
            ..:.|:.   .:.|:.::..:.|      :..|||....|:.|                   |..
Mouse   552 ESRLNSSFKGKIGTMSKSRASPP------VPSLVGTSGPRTLSGVSWPSDRLLPSPCYDPLCSGG 610

  Fly   766 ILDHSNSHSHSHS---NSSGGSNSNGSGNNNNSSSNASDNSGATVIYLSPEKREQRCNGGGGGGS 827
            :...|:|.||.::   :|...|...|.|:.:..|..:.|.       :.|..|
Mouse   611 LASPSSSESHPYASLDSSRAPSPQPGLGSIHADSPPSPDP-------IRPPSR------------ 656

  Fly   828 AGNEMNRWSNPVLDRLTGGICSSNSAQPSSQQS------------HQQQPHPSQQQQQQRRLPAA 880
              .::..:|.||..|.|.....:.|.|...:.|            .:...|..|.........:|
Mouse   657 --RKLFAFSRPVRSRDTDRFLDALSEQLGPRLSIVDDFLTPENDYEEMSFHDDQGSFVTNERSSA 719

  Fly   881 PVCSSAALRNESY-YMATNDNWSPAQMHLMTAHGNTALLIEDDAEPMSPTLPARPHDGQHCNTSS 944
            ..|.|::....|. |.:.:|:..|..:                :.|..|.||.  ||
Mouse   720 SECVSSSEEGSSLTYSSISDHIPPPPL----------------SPPPPPPLPF--HD-------- 758

  Fly   945 ANPSQNLAVGNQGPP---------IN-------------TVPGTPSTSSNFDATYSSQLSLETNS 987
            ..||...:.|.:|||         ||             .||..|...|.
Mouse   759 PKPSSRTSDGPRGPPQSLTKPLTQINHPVPPPPPPPLPPPVPCAPPMLSR--------------- 808

  Fly   988 GVEHFSRDALGRRSISEKHHAALDARETGTYQRNKKLREERERERRIQLTKSAVYG-----GSIE 1047
            ||.|       ||  ||..|.::           |:||.|     :::.::..::|     ...:
Mouse   809 GVGH-------RR--SETSHMSV-----------KRLRWE-----QVENSEGTIWGQLGEDSDYD 848

  Fly  1048 SLT--ARIASANAQFSGYKHAKTASSIE---QRETQQQLAAAEAEARDQL--------GDLGPSL 1099
            .|:  .:.......|...|..|.....|   ::|..:.|:..:|.....|        |:|...|
Mouse   849 KLSDMVKYLDLELHFGTQKPPKPVPGPEPFRKKEVVEILSHKKAYNTSILLAHLKLTPGELRQVL 913

  Fly  1100 GMKKSSSLE--SLQTMVQELQMSDEPRGHQALRAPRGRGREDSLRAAVVSEPD------ASKPR- 1155
            ...:...||  .|..::.....:||.:.:||.|...||          :||||      .|.|.
Mouse   914 MSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFREAPGR----------LSEPDQFVLQMLSVPEY 968

  Fly  1156 KTWLLEDGDHEGGFASQRNGPFQSSLND------GKHGC--------KSSR--AKKPSILRGIGH 1204
            ||.|             |:..||::|.:      |...|        |:||  ||....:..:|:
Mouse   969 KTRL-------------RSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVLAMGN 1020

  Fly  1205 MFRFGK---NRKDGVVPVDNYAVNISPPTSVVSTATSPQLQQQQQQQLQQHQQQ-----QQIPTA 1261
            ....|:   |:..|.  ..|:...::...:|...:|...:   ..:.|.||..:     |.:||.
Mouse  1021 YLNDGQPKTNKTTGF--KINFLTELNSTKTVDGKSTFLHI---LAKSLSQHFPELLGFAQDLPTV 1080

  Fly  1262 ALAA 1265
            .|||
Mouse  1081 PLAA 1084

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873
		PDZ_signaling	341..412	CDD:238492	27/205 (13%)
		CRS1_YhbY	<390..>436	CDD:294440	16/180 (9%)
		PDZ_signaling	462..548	CDD:238492	26/85 (31%)
		PDZ_signaling	<686..753	CDD:238492	12/72 (17%)
Grid2ip	NP_001152793.1	PDZ_signaling	9..69	CDD:238492	19/65 (29%)
		HN_L-delphilin-R1_like	122..201	CDD:259820	6/78 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..270		15/55 (27%)
		PDZ_signaling	269..342	CDD:238492	27/82 (33%)
		HN_L-delphilin-R2_like	378..457	CDD:259821	10/81 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	466..541		19/96 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..586		5/28 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..656		11/51 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	710..821		33/160 (21%)
		FH2	812..1180	CDD:280362	69/326 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900