DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment baz and Lnx1

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	NP_001153049.1	Gene:	Lnx1 / 16924	MGIID:	1278335	Length:	728	Species:	Mus musculus

Alignment Length:	791	Identity:	180/791 - (22%)
Similarity:	273/791 - (34%)	Gaps:	253/791 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 RHTYKVAAKQEGIPHGQLHKSYSLTLPKRPPSPSTYSCVKPDSWVTVTHLQTQSGILDPDDCVRD 86
            :|.::.:.|  |..|      |.||..::                    .::|.|.  ||.|...
Mouse   125 QHHFQTSCK--GASH------YGLTKDRK--------------------RRSQDGC--PDGCASL 159

  Fly    87 VA-------DDREQILAHFDDPGPD-PGVPQGGGDGASGSSSVGTGSPDIFRDPTNTEAPTCPRD 143
            :|       .....|....|:||.| |.......||...::|..:|..:      .|.|.  |.:
Mouse   160 MATTLSPEVSAAATISLMTDEPGLDNPAYVSSVEDGEPVANSSDSGRSN------RTRAR--PFE 216

  Fly   144 LSTPHIEVTSTTSGPMAGLGVGLMVRRSSDPNLLASLKAEGSNKRWSAAAPHY-AGGDSPE---- 203
            .||                     :|..|...:..:|.|....|..|..|.|. .|.|:.|
Mouse   217 RST---------------------MRSRSFKKINRALSALRRTKSGSVVANHVDQGRDNSENTTV 260

  Fly   204 -----RLFLDKAGGQLSPQWEEDDDPSHQLKEQLLHQQQPHAANGGSSSGNHQP----------- 252
                 |||.....|:::.......|||..|..:|:         |||.:    |
Mouse   261 PEVFPRLFHLIPDGEITSIKINRADPSESLSIRLV---------GGSET----PLVHIIIQHIYR 312

  Fly   253 ---FARSGRL----------SMQFLGDGNGYKWMEAAEKLQNQPPAQQTYQQGSHHAGHGQNGAY 304
               .||.|||          .|......:.|     |.:|..||  .|..:
Mouse   313 DGVIARDGRLLPGDIILKVNGMDISNVPHNY-----AVRLLRQP--CQVLR-------------- 356

  Fly   305 SSKSLPRESK-RKEPLGQAYESIREKDGEMLLIINEYGSP---LGLTALPDKEHGGGLLVQHVEP 365
              .::.||.| |........:|...:|....:|:|: .||   ||: .|..:....|:.:.:|..
Mouse   357 --LTVLREQKFRSRSNAHVPDSYGPRDDSFHVILNK-SSPEEQLGI-KLVRRVDEPGVFIFNVLN 417

  Fly   366 GSRAER-GRLRRDDRILEINGIKL-IGLTESQVQEQLRRALESSELRVRVLRGDRNRRQQRDSKV 428
            |..|:| |:|..:||:|.|||..| .|..||..     ..:::||.||.::..    ||.|.|..
Mouse   418 GGVADRHGQLEENDRVLAINGHDLRFGSPESAA-----HLIQASERRVHLVVS----RQVRQSSP 473

  Fly   429 AEMVEVATVS-PTRKPHAAPVGTSLQVANTRKLGRKIEIMLKKGPNGLGFSVTTRDNPAGG---- 488
            ....|...:| ..:.|......|:.:.|.|  ...|:..:.|.....||.:|      .||
Mouse   474 DIFQEAGWISNGQQSPGPGERNTASKPAAT--CHEKVVSVWKDPSESLGMTV------GGGASHR 530

  Fly   489 --HCPIYIKNILPRGAAIEDGRLKPGDRLLEVDGTPMTGKTQTDVVAILRGMPAGATVRIVVSRQ 551
              ..|||:.::.|.|....|||:|.||.||.|:|..:|..::|:.||||:..|:...::.:..::
Mouse   531 EWDLPIYVISVEPGGVISRDGRIKTGDILLNVNGIELTEVSRTEAVAILKSAPSSVVLKALEVKE 595

  Fly   552 QELAEQADQPAEKSAGVAVAPSVAPPAVPAAAAPAPPIPVQKSSSARSLFTHQQQSQLNESQHFI 616
            ||..|...                    |||.                           :|.|.:
Mouse   596 QEAQEDCS--------------------PAAL---------------------------DSNHNV 613

  Fly   617 DAGSESAASNDSLPPS--SNSWHSREELTLHIPVHDTEKAGLGVSVKGKTCSNL----NASGSSA 675
                        .||.  |.||....||..::                ..|.::    |.:||..
Mouse   614 ------------TPPGDWSPSWVMWLELPQYL----------------CNCKDVILRRNTAGSLG 650

  Fly   676 SSGSNGLMKHDGDLGIFVKNVIHGGAASRDGRLRMNDQLLSVNGVSLRGQNN---AEAMETLRRA 737
            .....|..::.|:...|:|:::.|..|..|||:|..|.||:|||.|..|..:   |..::.|:..
Mouse   651 FCIVGGYEEYSGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARMLKELKGR 715

  Fly   738 MVNTPGKHPGT 748
            :..|....|||
Mouse   716 ITLTIASWPGT 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873	23/119 (19%)
		PDZ_signaling	341..412	CDD:238492	25/75 (33%)
		CRS1_YhbY	<390..>436	CDD:294440	12/45 (27%)
		PDZ_signaling	462..548	CDD:238492	29/91 (32%)
		PDZ_signaling	<686..753	CDD:238492	23/66 (35%)
Lnx1	NP_001153049.1	mRING-HC-C3HC3D_LNX1	42..83	CDD:319693
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	185..220		10/63 (16%)
		NPXY motif	185..188		1/2 (50%)
		Interaction with MAGEB18. /evidence=ECO:0000250	186..244		16/86 (19%)
		PDZ_signaling	276..360	CDD:238492	21/119 (18%)
		PDZ_signaling	384..464	CDD:238492	28/86 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..500		3/18 (17%)
		PDZ_signaling	506..589	CDD:238492	29/88 (33%)
		PDZ_signaling	637..721	CDD:238492	24/83 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810