DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment baz and TAMALIN

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	NP_859062.1	Gene:	TAMALIN / 160622	HGNCID:	18707	Length:	395	Species:	Homo sapiens

Alignment Length:	377	Identity:	78/377 - (20%)
Similarity:	126/377 - (33%)	Gaps:	105/377 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   550 RQQELAEQADQPAEKSAGVAVAPS--VAPPAVPAAAA-PAPP----------------------- 588
            :|:|.|.....||.::....|||:  |..|..||||| |.||
Human    10 QQKEEAAATPDPAARTPDSEVAPAAPVPTPGPPAAAATPGPPADELYAALEDYHPAELYRALAVS 74

  Fly   589 ---IPVQKSSSARSLFTHQQQSQLNESQHFIDAGSESAASNDSLPPSSNSWHSREE-----LTLH 645
               :|.:|.|.    |..:..||..|.|..:....:...........:...|.|||     :|..
Human    75 GGTLPRRKGSG----FRWKNLSQSPEQQRKVLTLEKEDNQTFGFEIQTYGLHHREEQRVEMVTFV 135

  Fly   646 IPVHDTEKAGLGVSVKGKTCSNLNASGSSASSGSN----------GLMKHDGDLGIFVKNVIHGG 700
            ..||::..|.|.....|.|.:::|        |.|          .::|..|:  :.....::|.
Human   136 CRVHESSPAQLAGLTPGDTIASVN--------GLNVEGIRHREIVDIIKASGN--VLRLETLYGT 190

  Fly   701 A---ASRDGRLRMNDQLL----------------SVNGVSLRGQNNAEAMETLRRAMVNT---PG 743
            :   |..:.||:...|.|                .|:|:.::..:..:.:|::|..:...   ||
Human   191 SIRKAELEARLQYLKQTLYEKWGEYRSLMVQEQRLVHGLVVKDPSIYDTLESVRSCLYGAGLLPG 255

  Fly   744 KHP-GTITLLVGRKI--LRSA--SSSDILDHSNSHSHSH----------SNSSGGSNSNGSGNNN 793
            ..| |.:..:.||..  .|.|  .:.|.:.|:.....|.          :.:.|...:.......
Human   256 SLPFGPLLAVPGRPRGGARRARGDADDAVYHTCFFGDSEPPALPPPPPPARAFGPGPAETPAVGP 320

  Fly   794 NSSSNASDNSGATVIYLSPEKREQRCNGGGGGGSAGNEMNRWSNPVLDRLTG 845
            .....|:.:..|:|          ||.|.||||..|.....|:......|.|
Human   321 GPGPRAALSRSASV----------RCAGPGGGGGGGAPGALWTEAREQALCG 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873
		PDZ_signaling	341..412	CDD:238492
		CRS1_YhbY	<390..>436	CDD:294440
		PDZ_signaling	462..548	CDD:238492
		PDZ_signaling	<686..753	CDD:238492	15/89 (17%)
TAMALIN	NP_859062.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		17/41 (41%)
		PDZ_signaling	100..185	CDD:238492	16/94 (17%)
		Interaction with PSCD3. /evidence=ECO:0000250	181..258		12/76 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..349		13/65 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900