DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment baz and Lnx2

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	NP_542985.4	Gene:	Lnx2 / 140887	MGIID:	2155959	Length:	687	Species:	Mus musculus

Alignment Length:	853	Identity:	168/853 - (19%)
Similarity:	283/853 - (33%)	Gaps:	311/853 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 EGIPHGQLHKSYSLTLPKRPPSPSTYSCVKPDSWVTVTHLQTQSGILDPDDCVRDVADDREQILA 96
            |.:|..|...:.||       .|..:.|.: ..|....||....|.:| ||.|..:.  .:.:|.
Mouse     7 EMVPVEQASSTSSL-------DPLCFECGQ-QHWARENHLYNYQGEVD-DDLVCHIC--LQPLLQ 60

  Fly    97 HFDDPGPDPGVPQGGGDGASGSSSVGTGSPDIFRDPTN--TEAPTCPRDLSTPHIEVTSTTSGPM 159
            ..|.|                     .|.....:...|  .|...||.|....|.::...:|
Mouse    61 PLDTP---------------------CGHTFCHKCLRNFLQEKDFCPLDRKRLHFKLCKKSS--- 101

  Fly   160 AGLGVGLMVRRSSDPNLL--------------ASLKAEGSNKRWSAAAPHYAGGDSPERLFLDK- 209
                  ::|.:..|..|:              ..|:|...|:         ..|.|..|:.|::
Mouse   102 ------ILVHKLLDKLLVLCPFSPVCQDVMQRCDLEAHLKNR---------CPGASHRRVDLERR 151

  Fly   210 -------------------AGGQLSPQ--------------------WEED---DDPSHQ----- 227
                               ..|.|.|:                    |.|:   |:|:.:
Mouse   152 KTSQTQTQIEGETGSTVIDPPGTLPPETDCSGTVPGERNLTPASLPVWTEEPGLDNPAFEESAAA 216

  Fly   228 --LKEQL-----------LHQQQPHAANGGS-SSGNHQP--------------FARSGRLSMQFL 264
              :::.|           :|:..|:...|.| ..||..|              .||.|||   ..
Mouse   217 DSVQQPLSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRL---LA 278

  Fly   265 GDG----NGYKWMEA----AEKLQNQP--PAQQTYQQ----GSHHAGHGQNGAYSSKSLPRESKR 315
            ||.    |.|.....    |..:.:||  ..|.|..:    ||....|....|      ||:
Mouse   279 GDQILQVNNYDISNVSHNHARAVLSQPCSTLQLTVLRERRFGSRANSHADGSA------PRD--- 334

  Fly   316 KEPLGQAYESIREKDGEMLLIINEYGSPLGLTALPDKEHGGGLLVQHVEPGSRAERGRLRRDDRI 380
                 :.:        ::||...:....||:..:...:..|..::..:|.|..|:.|||..:||:
Mouse   335 -----EVF--------QVLLHKRDSTEQLGIKLVRRTDEPGVFILDLLEGGLAAQDGRLNSNDRV 386

  Fly   381 LEINGIKLIGLTESQVQEQLRRALESSELRVRVLRGDRNRRQQRDSKVAEMVEVATVSPTRKP-- 443
            |.|||..|    :....|...:.:::|..||.:                      |::...||
Mouse   387 LAINGHDL----KHGTPELAAQIIQASGERVNL----------------------TIARPGKPQP 425

  Fly   444 --------------HAAPVGTSLQVANTRKLGRKI-----EIMLKKGPN-GLGFSVTTRDNPAGG 488
                          ||.|...| :..:.:.|.|.:     .|.:||.|: .||.:|........|
Mouse   426 SNGSREAGAHSSSNHAQPPSHS-RPGSHKDLTRCVTCQEKHITVKKEPHESLGMTVAGGRGSKSG 489

  Fly   489 HCPIYIKNILPRGAAIEDGRLKPGDRLLEVDGTPMTGKTQTDVVAILRGMPAGATVRIVVSRQQE 553
            ..||::.::.|.|....|||:|.||.||.::|..:|..:.::.||:|:...|...| |:.:.:.:
Mouse   490 ELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAV-ILKALEVQ 553

  Fly   554 LAEQADQPAEKSAGVAVAPSVAPPAVPAAAAPAPPIPVQKSSSARSLFTHQQQSQLNESQHFIDA 618
            :||:|.|.                                        |.:|.|..:|:::  ||
Mouse   554 IAEEAAQA----------------------------------------TEEQPSAFSENEY--DA 576

  Fly   619 GSESAASNDSLPPSSNSWHSREELTLHIPVHDTEKAGLGVSVKGKTCSNL----NASGSSASSGS 679
                     |..||...|                   ||:.....:|.::    :..||...|..
Mouse   577 ---------SWSPSWVMW-------------------LGLPSALHSCHDIVLRRSYLGSWGFSIV 613

  Fly   680 NGLMKHDGDLGIFVKNVIHGGAASRDGRLRMNDQLLSVNGVSLRGQNNAEAMETLRRAMVNTPGK 744
            .|..::..:...|:|.::.|..|..||||:..|.:::|||:|..|.:::..:..|:..      :
Mouse   614 GGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQ------R 672

  Fly   745 HPGTITLL 752
            :..|:|::
Mouse   673 NKVTLTVI 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873	20/113 (18%)
		PDZ_signaling	341..412	CDD:238492	19/70 (27%)
		CRS1_YhbY	<390..>436	CDD:294440	4/45 (9%)
		PDZ_signaling	462..548	CDD:238492	29/91 (32%)
		PDZ_signaling	<686..753	CDD:238492	17/67 (25%)
Lnx2	NP_542985.4	mRING-HC-C3HC3D_LNX2	46..90	CDD:319694	13/67 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..175		3/29 (10%)
		NPXY motif	207..210		1/2 (50%)
		PDZ	229..315	CDD:214570	21/88 (24%)
		PDZ_signaling	336..418	CDD:238492	23/115 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	417..454		6/37 (16%)
		PDZ_signaling	463..539	CDD:238492	25/75 (33%)
		PDZ_signaling	596..680	CDD:238492	21/89 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900