DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment baz and Patj

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_038965114.1	Gene:	Patj / 140581	RGDID:	1565362	Length:	1858	Species:	Rattus norvegicus

Alignment Length:	1663	Identity:	327/1663 - (19%)
Similarity:	533/1663 - (32%)	Gaps:	556/1663 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 PDDCVRDVADDREQILAHFDDPGPDPGVPQGGGDGASGSSSVGTGSPDIFRDPTNTEAPTCPRDL 144
            |.||..:....|:.:|..     .|..:..|.......|.:.....|...|...........:..
  Rat    68 PSDCSANFDFSRKGLLVF-----TDGSITNGNAHRPCSSITASESLPWTQRSGNEDFTSVIQQMA 127

  Fly   145 STPHIEVTSTTSGPMAGLGVGLMVRRSSDPNLLASLKAE---GSNKRWSAAAPHYAGGDSPERLF 206
            ...|||..........|||..::..||....|:.....|   ||            ..|..:||
  Rat   128 QGRHIEYIDIERPSTGGLGFSVVALRSQSLGLIDIFVKEVHPGS------------VADRDQRL- 179

  Fly   207 LDKAGGQLSPQWEEDDDPSHQLKEQLLHQQQPHAANGGSSSGNHQPFARSGRLSMQFLGDGNGYK 271
              |...|:   ...:|.|   |.:.:.|||                       ::..|....|..
  Rat   180 --KENDQI---LAINDTP---LDQNISHQQ-----------------------AIALLQQATGSL 213

  Fly   272 WMEAAEKLQNQPPAQQTYQQGSHHAGHGQNGAYSSK---SLPRESKRKEPLGQAYESIREKDGEM 333
            .:..|.::                 ||.|:...:|.   :||             |::|....|.
  Rat   214 RLVVAREV-----------------GHTQSRTSTSSADTTLP-------------ETVRWGHTED 248

  Fly   334 LLIINEYGSPLGLTALPDKEHGGGLLVQHVEPGSRAER-GRLRRDDRILEINGIKLIGLTESQVQ 397
            :.:||: ||.||...:..|  ..|::|:.:.||..|:| |||:..|.||:|....:.|:|..||.
  Rat   249 VELIND-GSGLGFGIVGGK--SSGVVVRTIVPGGLADRDGRLQTGDHILKIGSTNVQGMTSEQVA 310

  Fly   398 EQLRRALESSELRVRVLRGDRNRRQQRDSKVAEMVEVATVSPTRKPHAAPVGTSLQVANTRKLGR 462
            :.||..  .:.:|:.|.|.             .:.|:|...||  |.:.||  :|.|..||.||.
  Rat   311 QVLRNC--GNSVRMLVARD-------------PVGEIAVTPPT--PASLPV--ALPVVATRTLGS 356

  Fly   463 --------KIEIMLKKGPN-GL---GFSVTTRDNPAGGHCPIYIKNILPRGAAIEDGRLKPGDRL 515
                    .:|::.|.|.: |:   |:..|.....|.|   ||:|:|:|..||..:|:::..|::
  Rat   357 DSSPFETYNVELVKKDGQSLGIRIVGYVGTAHPGEASG---IYVKSIIPGSAAYHNGQIQVNDKI 418

  Fly   516 LEVDGTPMTGKTQTDVVAILRGMPAGATVRI-VVSRQQEL-AEQADQPAEKSAGVAVAPSVAPPA 578
            :.|||..:.|....|||.:||.  ||..|.: :|.|:..| |...:||:.:.   |||   .||.
  Rat   419 VAVDGVNIQGFANQDVVEVLRN--AGQVVHLTLVRRKTSLSASPFEQPSSRE---AVA---EPPE 475

  Fly   579 VPAAAAPAPPIPVQKSSSARSLFTHQQQSQLNESQHFIDAGSESAASNDSLPPS------SNSWH 637
            ||.......|     .:::|     .:..::.|....:...:..|.....:.|.      .|...
  Rat   476 VPELTGSLKP-----ETNSR-----MEAEEIGERLDNLRKDTVQALEKPDVYPEDIPGCPENELK 530

  Fly   638 SR-----------------------EELTLH---IPVHDTEKAGL-------------------- 656
            ||                       |||..:   :|:| |.:.|:
  Rat   531 SRWENLLGPDYEVMVATLDTQIADDEELQKYSKLLPIH-TLRLGMEVDSFDGHHYISSIAPGGPV 594

  Fly   657 ----------------GVSVKGKT-------------------CSNL---NASGSSASSGSNGLM 683
                            ||.:.||:                   |..|   .||.....:....|:
  Rat   595 DTLNLLQPEDELLEVNGVQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRTVEPSLL 659

  Fly   684 K-------------HDGDLG-----------------------------------IFVKNVIHGG 700
            :             .||:|.                                   |.:::::..|
  Rat   660 EAEVDRSVDVSTEDDDGELALWSPEVKTVELVKDCKGLGFSILDYQDPLDPMRSVIVIRSLVADG 724

  Fly   701 AASRDGRLRMNDQLLSVNGVSLRGQNNAEAMETLRRAMVNTPGKHPGTITLLVGRKILRSASSSD 765
            .|.|.|.|...|:|:|||..||.....|||:|.|:..       .||.:.|.:.:.::....
  Rat   725 VAERSGELLPGDRLVSVNEFSLDNATLAEAVEVLKAV-------PPGVVHLGICKPLVEEEK--- 779

  Fly   766 ILDHSNSHSHSHSNSSGGSNSNGSGNNNNSSSNASDNSGATVIYLSPE----------------- 813
              :....|...|||::|         :|:.|........:::|..:|:
  Rat   780 --EEKEEHFIFHSNNNG---------DNSESPETVHEIHSSLILEAPQGFRDEPYLEELVDEPFL 833

  Fly   814 ---KREQRCNGGGGGGSAGNEMNRWSNPVLDR-------LTGGICSSNSAQPSSQQSHQQQPHPS 868
               |..|.........|...||:.:.:|.|:|       |..........:....::|...||..
  Rat   834 DLGKSLQFQQKDMDSSSEAWEMHEFLSPRLERRGEEREMLVDEEYEIYQDRLRDMEAHPPPPHIR 898

  Fly   869 QQQQQQRRLPAAPVCSSAALRNESYYMATNDNWSPAQM---HLMTAHGNTALLIEDDAEPMSPTL 930
            :......||.                :.....|..|.:   .::..|         |.|.|....
  Rat   899 EPTSASPRLD----------------LQAGPQWLHADLSGGEILECH---------DTESMMTAY 938

  Fly   931 PARPHDGQHCNTSSANPSQNLAVGNQGPPINTVPGTPSTSSN-----FDATYSSQLSLE-TNSGV 989
            |....|.....|.....:..|   :..||:      ||:..|     ||       .|| .:|.|
  Rat   939 PQEMQDYSFSTTDMMKETFGL---DSRPPM------PSSEGNGQHGRFD-------DLEHLHSLV 987

  Fly   990 EHFSRDALGRRSISEKHHAALDARETGTYQRNKKLREERERER---------RIQLTKSAVYGGS 1045
            .| ..| ||..:.|       |.:..|.......:.:.||:|.         |: :||.:.:.|.
  Rat   988 SH-GLD-LGMMTPS-------DLQGPGVLVDLPAVTQRREQEELPLYRLPSARV-VTKPSSHVGM 1042

  Fly  1046 IESLTARIASANAQFSGYKHAKTASSIEQRETQQQLAAAEAEARDQLGDLGP------------S 1098
            :.|               :||..|..:.:||      ..|.|........||            |
  Rat  1043 VSS---------------RHANAACELPERE------EGEGEETPNFSHWGPPRIVEIFREPNVS 1086

  Fly  1099 LGMKKSSSLESLQTMVQELQMSDEPRG---HQALR-APRGRGREDSLRAAVVSEPDASKPRKTWL 1159
            ||:    |:...||:::.|:..:|.:|   .|.|. :|.|                     ||..
  Rat  1087 LGI----SIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAG---------------------KTKA 1126

  Fly  1160 LEDGD---HEGGFASQRNGPFQSSLNDGKHGCKSSRAKKPSILRGIGHMFRFGKNRKDGVVPVDN 1221
            |:.||   ...|...|                .:|.|:....::..|:             ||..
  Rat  1127 LKTGDKILEVSGVDLQ----------------NASHAEAVEAIKSAGN-------------PVVF 1162

  Fly  1222 YAVNISPPTSVVSTA-----TSPQLQQQQQQQLQQHQQQQQIPTAALAALERNG-KPPAYQPPPP 1280
            ...::|....|:.:.     |.||.|.|..|:.:               .:|:| .||..:.|||
  Rat  1163 VVQSLSSTPRVIPSVNNKGKTPPQNQDQNTQEKK---------------AKRHGTAPPPMKLPPP 1212

  Fly  1281 LPAPNGVGSNGIHQNDIFNHRY-QHYANYE-DLHQQHQQHQISGGDSTTSISETLSESTLECM-- 1341
            ..||:.........:.:.:.:. |.||:.. :||....:...:|...:.:.::..|..::..:
  Rat  1213 YRAPSADTEESEEDSALTDKKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGI 1277

  Fly  1342 ----------RQQVIRQRIKVEAE---SRRHQHYHSQRSA--------------RSQD-VSMHST 1378
                      |.:|..:.:::..:   .|.||:    .||              |::| |:..:.
  Rat  1278 NPDGPAAADGRMRVGDELLEINNQILYGRSHQN----ASAIIKTAPTRVKLVFIRNEDAVNQMAV 1338

  Fly  1379 SSGSQPGSLAQPQAQSNGVRPMSSYYEYETVQQQRVGSIKHSHSSSATSSSSSPINVPHWKAAAM 1443
            :....|.....|.....|..|:|| .|..:|..:.:...:.|.....|.:....:.....||:.
  Rat  1339 APFPVPSHSPSPVEDLGGTEPVSS-EEDSSVDAKPLPERESSKPEDLTQAVDDSMVAEQEKASE- 1401

  Fly  1444 NGYSPASLNSSARSRGPFVTQVTIREQSSGGIPAHLLQ 1481
               ||.|.....:..| :..||:...|.....||.|.|
  Rat  1402 ---SPDSAARQMKQPG-YSAQVSSSSQEIPSAPAPLCQ 1435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873	18/93 (19%)
		PDZ_signaling	341..412	CDD:238492	25/71 (35%)
		CRS1_YhbY	<390..>436	CDD:294440	10/45 (22%)
		PDZ_signaling	462..548	CDD:238492	29/98 (30%)
		PDZ_signaling	<686..753	CDD:238492	24/101 (24%)
Patj	XP_038965114.1	L27_2	8..65	CDD:312549
		PDZ_signaling	135..218	CDD:238492	22/126 (17%)
		PDZ_signaling	248..325	CDD:238492	27/81 (33%)
		PDZ_signaling	366..450	CDD:238492	29/88 (33%)
		CtpA	<391..>511	CDD:223864	39/140 (28%)
		PDZ_signaling	572..636	CDD:238492	5/63 (8%)
		PDZ	684..773	CDD:214570	21/95 (22%)
		PDZ_signaling	1074..1165	CDD:238492	25/144 (17%)
		PDZ	1244..1329	CDD:214570	11/88 (13%)
		PDZ	1471..1578	CDD:214570
		PDZ_signaling	1590..1670	CDD:238492
		PDZ_signaling	1731..1816	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810