DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment baz and Patj

DIOPT Version :9

Sequence 1:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	NP_766284.2	Gene:	Patj / 12695	MGIID:	1277960	Length:	1834	Species:	Mus musculus

Alignment Length:	1593	Identity:	324/1593 - (20%)
Similarity:	512/1593 - (32%)	Gaps:	549/1593 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 HIEVTSTTSGPMAGLGVGLMVRRSSDPNLLASLKAEGSNKRWSAAAPHYAGGDSPERLFLDKAGG 212
            |:|..........|||..::..||....|:                          .:|:.
Mouse   131 HVEYIDIERPSTGGLGFSVVALRSQSLGLI--------------------------DIFVK---- 165

  Fly   213 QLSPQWEEDDDPSHQLKE--QLLHQQQPHAANGGSSSGN--HQPFARSGRLSMQFLGDGNGYKWM 273
            ::.|....|.|  |:|||  |:|      |.|......|  ||.       ::..|....|...:
Mouse   166 EVHPGSVADRD--HRLKENDQIL------AINDTPLDQNISHQQ-------AIALLQQATGSLRL 215

  Fly   274 EAAEKLQNQPPAQQTYQQGSHHAGHGQNGAYSSK---SLPRESKRKEPLGQAYESIREKDGEMLL 335
            ..|.::                 ||.|..|.:|.   :||             |::.....|.:.
Mouse   216 VVAREV-----------------GHTQGRASTSSADTTLP-------------ETVCWGHTEEVE 250

  Fly   336 IINEYGSPLGLTALPDKEHGGGLLVQHVEPGSRAER-GRLRRDDRILEINGIKLIGLTESQVQEQ 399
            :||: ||.||...:..|  ..|::|:.:.||..|:| |||:..|.||:|.|..:.|:|..||.:.
Mouse   251 LIND-GSGLGFGIVGGK--SSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQV 312

  Fly   400 LRRALESSELRVRVLRGDRNRRQQRDSKVAEMVEVATVSPTRKPHAAPVGTSLQVANTRKLGR-- 462
            ||..  .:.:|:.|.|.             .:.|:|...||  |.:.||  :|....||.|..
Mouse   313 LRNC--GNSVRMLVARD-------------PVGEIAVTPPT--PVSLPV--ALPAVATRTLDSDR 358

  Fly   463 ------KIEIMLKKGPN-GL---GFSVTTRDNPAGGHCPIYIKNILPRGAAIEDGRLKPGDRLLE 517
                  .:|::.|.|.: |:   |:..|.....|.|   ||:|:|:|..||..:|:::..|:::.
Mouse   359 SPFETYSVELVKKDGQSLGIRIVGYVGTAHPGEASG---IYVKSIIPGSAAYHNGQIQVNDKIVA 420

  Fly   518 VDGTPMTGKTQTDVVAILRGMPAGATVRIVVSRQQELAEQADQPAEKSAGVAVAPSVA-PPAVP- 580
            |||..:.|....|||.:||.  ||..|.:.:.|::  ...:..|.|.|:.   ..:|| ||.||
Mouse   421 VDGVNIQGFANQDVVEVLRN--AGQVVHLTLVRRK--TSLSASPFEHSSS---RETVAEPPKVPE 478

  Fly   581 AAAAPAPP--IPVQKSSSARSLFTHQQQSQLNESQHFIDAGSESAASNDSLPPS-SNSWHSREEL 642
            .|.:|.|.  :.|:.......|.        |...:.:.|..:.....:.:|.| .|...||.|.
Mouse   479 RAGSPKPEANLSVEAEEIGERLD--------NLKNNTVQALEKPDVYPEKVPGSPENELKSRWEN 535

  Fly   643 TLHIPVHDTEKAGLGVSVKGKTCSNLNASGSSASSGSNGLMKHDGDLGI---------FVKNVIH 698
            .|. |.::...|.|...:         |........|..|..|...||:         ::.:|..
Mouse   536 LLG-PDYEVMVATLDAQI---------ADDEELQKYSKLLPIHTLRLGMEVDSFDGHHYISSVAP 590

  Fly   699 GGAASRDGRLRMNDQLLSVNGVSLRGQNNAEAMETLRRAMVNTPGKHPGTITLLVGRKILRSASS 763
            ||.......|:..|:||.|||:.|.|::..||:..|:..        |...||:..|::....:|
Mouse   591 GGPVDTLNLLQPEDELLEVNGMQLYGKSRREAVSFLKEV--------PPPFTLVCCRRLFDDEAS 647

  Fly   764 SD--------ILDHSNSHSHSHSNSSGGSNSNGSGNNNNSSSNASDNSGATVIYLSPEKRE---- 816
            .|        :|:....||                    ...|..|:....:...|||.:.
Mouse   648 VDEPRTMEPALLEAEVDHS--------------------VDVNIEDDDDGELALWSPEVKTVELV 692

  Fly   817 QRCNGGG-------------------------GGGSAGNEM---------NRWSNPVLDRLT--- 844
            :.|.|.|                         |......|:         |.:|   ||..|
Mouse   693 KDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGELLPGDRLVSVNEFS---LDNATLAE 754

  Fly   845 ----------G----GIC------------------SSNSAQPS-------------SQQSHQQQ 864
                      |    |||                  :.:|::|:             :.|..:.:
Mouse   755 AVEVLKAVPPGVVHLGICKPLVEDEKEERFSLHSNNNGDSSEPADAVHEIHSSLILEAPQGFRDE 819

  Fly   865 PHPSQ------------QQQQQRRLPAAPVCSSAAL------------RNESYYMATNDNWSPAQ 905
            |:..:            .|.||:.:.:    ||.|.            |.|...|..::.:...|
Mouse   820 PYLEELVDEPFLDLGKSLQFQQKDVDS----SSEAWEMHEFLSPPLDGRGEEREMLVDEEYELYQ 880

  Fly   906 MHLMTAHGNTALLIEDDAEPMSPTL----------------------------PARPHDGQHCNT 942
            .||.....|.......:|.|.||.|                            .|.|.:.|..:.
Mouse   881 DHLRAMESNPPPPHIREAAPASPVLELQAGTQWLHANLSGGERLECHDAESMMSAYPQEMQQYSY 945

  Fly   943 SSANPSQNLAVGNQGPPINTVPGTPSTSSN-----FDATYSSQLSLETNSGVEHFSRDALGRRSI 1002
            |:|:..:.....:...||      ||:..|     ||.  ...|...|:|.::      ||....
Mouse   946 STADMMEETFGLDSRAPI------PSSEGNGQHGRFDD--MGHLHSLTSSSLD------LGMMIP 996

  Fly  1003 SEKHHAALDARETGTYQRNKKLREERERE---------RRIQLTKSAVYGGSIESLTARIASANA 1058
            |       |.:..|.......:.:.||:|         .|: :||.:.:.|.:.|
Mouse   997 S-------DLQGPGVLVDLPAVAQRREQEDLPLYRLPSARV-VTKPSSHMGLVSS---------- 1043

  Fly  1059 QFSGYKHAKTASSIEQRETQQQLAAAEAEARDQLGDLGP------------SLGMKKSSSLESLQ 1111
                 :||..|..:.:||      ..|.|........||            |||:    |:...|
Mouse  1044 -----RHANAACELPERE------EGEGEETPNFSHWGPPRIVEIFREPNVSLGI----SIVGGQ 1093

  Fly  1112 TMVQELQMSDEPRG---HQALR-APRGRGREDSLRAAVVSEPDASKPRKTWLLEDGD---HEGGF 1169
            |:::.|:..:|.:|   .|.|. :|.|                     ||..|:.||   ...|.
Mouse  1094 TVIKRLKNGEELKGIFIKQVLEDSPAG---------------------KTNALKTGDKILEVSGV 1137

  Fly  1170 ASQRNGPFQSSLNDGKHGCKSSRAKKPSILRGIGHMFRFGKNRKDGVVPVDNYAVNISPPTSVVS 1234
            ..|                .:|.|:....::..|:             ||.....::|....|:.
Mouse  1138 DLQ----------------NASHAEAVEAIKSAGN-------------PVVFVVQSLSSTPRVIP 1173

  Fly  1235 TAT----SPQLQQQQQQQLQQHQQQQQIPTAALAALERNGK-----PPAYQPPPPLPAPNGVGSN 1290
            |..    :|...|.|..|                  ||..|     ||..:.|||..||: ....
Mouse  1174 TVNNKGKTPAPNQDQNTQ------------------ERKAKRHGTAPPPMKLPPPYRAPS-ADME 1219

  Fly  1291 GIHQNDIFNHR--YQHYANYE-DLHQQHQQHQISG----------------------------GD 1324
            |..::.....:  .|.||:.. :||....:...:|                            .|
Mouse  1220 GSEEDCALTDKKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAAD 1284

  Fly  1325 STTSISETLSESTLECMRQQVIRQRIKVEAESRRHQHYHS---QRSARSQDVSMHSTSSGSQPGS 1386
            ....|.:.|.|     :..|::        ..|.||:..:   ....|.:.|.:.:..:.||...
Mouse  1285 GRMRIGDELLE-----INNQIL--------YGRSHQNASAIIKTAPTRVKLVFIRNEDAVSQMAV 1336

  Fly  1387 LAQPQAQSNGVRPMSSYYEYETVQQQRVGSIKHSHSSSATSSSSSPIN-VPHWKAAAMNGYSPAS 1450
            ...|:. |:...|:......|.|..:...|:...|.....||....:: |......|.......|
Mouse  1337 APFPEL-SHSPSPVEDLGGTELVSSEEESSVDAKHLPEPESSKPEDLSQVVDDNMVAEQQKESES 1400

  Fly  1451 LNSSA--RSRGPFVTQVTIREQSSGGIPAHLLQ 1481
            .:|:|  ..:..:.|||:...|.|...||.|.|
Mouse  1401 PDSAACQIKQQTYSTQVSSSSQDSPSSPAPLCQ 1433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873	7/25 (28%)
		PDZ_signaling	341..412	CDD:238492	26/71 (37%)
		CRS1_YhbY	<390..>436	CDD:294440	10/45 (22%)
		PDZ_signaling	462..548	CDD:238492	29/97 (30%)
		PDZ_signaling	<686..753	CDD:238492	20/75 (27%)
Patj	NP_766284.2	L27_2	8..65	CDD:312549
		PDZ_signaling	135..218	CDD:238492	23/127 (18%)
		PDZ_signaling	248..325	CDD:238492	28/81 (35%)
		PDZ_signaling	363..450	CDD:238492	29/91 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	456..488		12/34 (35%)
		PDZ_signaling	572..636	CDD:238492	19/71 (27%)
		PDZ	685..774	CDD:214570	15/91 (16%)
		PDZ_signaling	1072..1163	CDD:238492	25/144 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1171..1219		16/66 (24%)
		PDZ	1242..1327	CDD:214570	13/97 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1340..1453		23/95 (24%)
		MPDZ_u10	<1453..1468	CDD:374710
		PDZ	1469..1554	CDD:214570
		PDZ_signaling	1566..1646	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1657..1676
		PDZ_signaling	1707..1792	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1811..1834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810